Brand  (β version)

PDB ID: 1TDG

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Ligands
Code Name Style Show Link
MA4 Cyclohexyl-hexyl-beta-D-maltoside PoSSuM
MDD Malonaldehyde PoSSuM
MPD (4s)-2-methyl-2,4-pentanediol PoSSuM
MRD (4r)-2-methylpentane-2,4-diol PoSSuM
TBE Tazobactam intermediate PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1TDG   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Complex of S130G SHV-1 beta-lactamase with tazobactam
Release Data : 2004-11-23
Compound :
mol_id molecule chains synonym
1 Beta-lactamase SHV-1 A PIT-2
ec: 3.5.2.6
mutation: S130G
Source :
mol_id organism_scientific expression_system
1 Klebsiella pneumoniae  (taxid:573) Escherichia coli str. K-12 substr. DH10B  (taxid:316385)
gene: bla
expression_system_strain: DH10B
expression_system_vector_type: plasmid
expression_system_plasmid: pBC SK
Authors : Sun, T., Bethel, C.R., Bonomo, R.A., Knox, J.R.
Keywords : S130G SHV-1 class A beta-lactamase, penicillinase, beta-lactam hydrolase, detergent binding, inhibitor complex, tazobactam, aldehyde, cymal-6, hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.8 Å )
Citation :

Inhibitor-resistant class A beta-lactamases: consequences of the Ser130-to-Gly mutation seen in Apo and tazobactam structures of the SHV-1 variant

Sun, T.,Bethel, C.R.,Bonomo, R.A.  et al.
(2004)  Biochemistry  43 : 14111 - 14117

PubMed: 15518561
DOI: 10.1021/bi0487903

Reaction

Chain : A
UniProt : P14557 (BLA1_KLEPN)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PROSITE-ProRule:PRU10101, PubMed:10231522, PubMed:19351161, PubMed:22908166, PubMed:23252553
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