Brand  (β version)

PDB ID: 1T7P

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Ligands
Code Name Style Show Link
DG3 2'-3'-dideoxyguanosine-5'-triphosphate PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
Code Name Show
2DA 2',3'-dideoxyadenosine-5'-monophosphate
Glycosylation
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Modification
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Structure summary

Code : 1T7P   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/DNA
Title : T7 DNA POLYMERASE COMPLEXED TO DNA PRIMER/TEMPLATE,A NUCLEOSIDE TRIPHOSPHATE, AND ITS PROCESSIVITY FACTOR THIOREDOXIN
Release Data : 1998-02-25
Compound :
mol_id molecule chains
1 DNA (5'-D(P*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*2DA)-3') P
mol_id molecule chains
2 DNA (5'-D(P*CP*CP*TP*TP*GP*GP*CP*AP*CP*TP*GP*GP*C)-3') T
mol_id molecule chains synonym
3 DNA-directed DNA polymerase A Gene product 5,Gp5
ec: 2.7.7.7,3.1.11.-
mutation: DEL(118-123)
mol_id molecule chains synonym
4 Thioredoxin 1 B Trx-1
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific organism_common expression_system
3 Enterobacteria phage T7  (taxid:10760) Bacteriophage T7 Escherichia coli  (taxid:562)
mol_id organism_scientific
4 Escherichia coli O157:H7  (taxid:83334)
gene: trxA, Z5291, ECs4714
Authors : Doublie, S., Tabor, S., Long, A.M., Richardson, C.C., Ellenberger, T.
Keywords : T7 DNA POLYMERASE, DNA REPLICATION, NUCLEOTIDYL TRANSFERASE, THIOREDOXIN, PROCESSIVITY FACTOR, COMPLEX (HYDROLASE-ELECTRON TRANSPORT-DNA), TRANSFERASE-DNA COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution.

Doublie, S.,Tabor, S.,Long, A.M.  et al.
(1998)  Nature  391 : 251 - 258

PubMed: 9440688
DOI: 10.1038/34593

Reaction

Chain : A
UniProt : P00581 (DPOL_BPT7)
Reaction: EC: Evidence:
Physiological Direction:
DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate 2.7.7.7 HAMAP-Rule:MF_04101, PubMed:24591606
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000255 | HAMAP-Rule:MF_04101
ECO:0000305 | PubMed:9440688
-
Chain : B
UniProt : P0AA27 (THIO_ECO57)
Reaction : -