Brand  (β version)

PDB ID: 1RCJ

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Ligands
Code Name Style Show Link
MA4 Cyclohexyl-hexyl-beta-D-maltoside PoSSuM
TBI Tazobactam trans-enamine intermediate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1RCJ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of E166A mutant of SHV-1 beta-lactamase with the trans-enamine intermediate of tazobactam
Release Data : 2004-02-17
Compound :
mol_id molecule chains synonym
1 Beta-lactamase SHV-1 A PIT-2
ec: 3.5.2.6
mutation: E166A
Source :
mol_id organism_scientific expression_system
1 Klebsiella pneumoniae  (taxid:573) Escherichia coli  (taxid:562)
gene: BLA, SHV1
Authors : Padayatti, P.S., Helfand, M.S., Totir, M.A., Carey, M.P., Hujer, A.M., Carey, P.R., Bonomo, R.A., van den Akker, F.
Keywords : BETA-LACTAMASE, BETA-LACTAM HYDROLASE, PENICILLINASE, DETERGENT BINDING, INHIBITOR DESIGN, COVALENT INTERMEDIATE, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.63 Å )
Citation :

Tazobactam Forms a Stoichiometric trans-Enamine Intermediate in the E166A Variant of SHV-1 beta-Lactamase: 1.63 A Crystal Structure

Padayatti, P.S.,Helfand, M.S.,Totir, M.A.  et al.
(2004)  Biochemistry  43 : 843 - 848

PubMed: 14744126

Reaction

Chain : A
UniProt : P14557 (BLA1_KLEPN)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PROSITE- ProRule:PRU10101
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