Het-PDB Navi2 (PDB: 1QXE)

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Ligands
Code	Name	Link
SO4	Sulfate ion	PoSSuM
OXY	Oxygen molecule	PoSSuM
HEM	Protoporphyrin ix containing Fe	PoSSuM
FUX	5-hydroxymethyl-furfural	PoSSuM

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Download interaction data: 1QXE

Code :

1QXE PDBj RCSB PDB PDBe

Header :

OXYGEN STORAGE/TRANSPORT

Title :

Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds

Release Data :

2003-09-16

Compound :

mol_id	molecule	chains
1	Hemoglobin alpha chain	A,C
	fragment: alpha chain

mol_id	molecule	chains
2	Hemoglobin beta chain	B,D
	fragment: beta chain

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human
	organ: blood cell: erythrocytes

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	organ: blood cell: erythrocytes

Authors :

Safo, M.K., Abdulmalik, O., Danso-Danquah, R., Nokuri, S., Joshi, G.S., Musayev, F.N., Asakura, T., Abraham, D.J.

Keywords :

allosteric; antisickling; relaxed state; hemoglobin; sickle cell; 5-hydroxymethyl-2-furfural, OXYGEN STORAGE-TRANSPORT COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 1.85 Å )

Citation :

Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds

Safo, M.K.,Abdulmalik, O.,Danso-Danquah, R. et al.
(2004) J.Med.Chem. 47 : 4665 - 4676

PDB ID: 1QXE