PDB ID: 1QQP
Hetero Atom Contents
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Structure summary
Code : | 1QQP PDBj RCSB PDB PDBe | ||||||||||||||||||||||||||||||||||||||||||||||||
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Header : | VIRUS | ||||||||||||||||||||||||||||||||||||||||||||||||
Title : | FOOT-AND-MOUTH DISEASE VIRUS/ OLIGOSACCHARIDE RECEPTOR COMPLEX. | ||||||||||||||||||||||||||||||||||||||||||||||||
Release Data : | 1999-06-18 | ||||||||||||||||||||||||||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Fry, E.E., Lea, S.M., Jackson, T., Newman, J.W.I., Ellard, F.M., Blakemore, W.E., Abu-Ghazaleh, R., Samuel, A., King, A.M.Q., Stuart, D.I. | ||||||||||||||||||||||||||||||||||||||||||||||||
Keywords : | VIRUS, HEPARAN SULPHATE, VIRUS-RECEPTOR INTERACTIONS/PROTEIN-CARBOHYDRATE INTERACTIONS, VIRUS/VIRAL PROTEIN, Icosahedral virus | ||||||||||||||||||||||||||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.90 Å ) | ||||||||||||||||||||||||||||||||||||||||||||||||
Citation : |
The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex.
Fry, E.E.,Lea, S.M.,Jackson, T.
et al.
PubMed: 9927414 Structure of a Major Immunogenic Site on Foot-and-Mouth Disease Virus
Logan, D.,Abu-Ghazaleh, R.,Blakemore, W.
et al.
DOI: 10.1038/362566a0 The Three-Dimensional Structure of Foot-and-Mouth Disease Virus at 2.9 Angstroms Resolution
Acharya, R.,Fry, E.,Stuart, D.
et al.
DOI: 10.1038/337709a0 |
Reaction
Chain : | 4 |
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UniProt : | P03305 (POLG_FMDVO) |
Reaction : | Reaction=Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|- Arg- and -Lys-|-Arg-.; EC=3.4.22.46; Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15; Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:11128, Rhea:RHEA- COMP:11129, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:83400; EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539}; Reaction=Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.; EC=3.4.22.28; Evidence={ECO:0000255|PROSITE-ProRule:PRU01222}; |