Brand  (β version)

PDB ID: 1QQP

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Ligands
Code Name Style Show Link
IDS 2-O-sulfo-alpha-L-idopyranuronic acid PoSSuM
IDX 2-O-sulfo-alpha-L-gulopyranuronic acid PoSSuM
SGN 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose PoSSuM
: Polysaccharide
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1QQP   PDBj   RCSB PDB   PDBe
Header : VIRUS
Title : FOOT-AND-MOUTH DISEASE VIRUS/ OLIGOSACCHARIDE RECEPTOR COMPLEX.
Release Data : 1999-06-18
Compound :
mol_id molecule chains synonym
1 PROTEIN (GENOME POLYPROTEIN) 1 FMDV
other_details: STRAIN BFS, 1860
mol_id molecule chains synonym
2 PROTEIN (GENOME POLYPROTEIN) 2 FMDV
other_details: STRAIN BFS, 1860
mol_id molecule chains synonym
3 PROTEIN (GENOME POLYPROTEIN) 3 FMDV
other_details: STRAIN BFS, 1860
mol_id molecule chains synonym
4 PROTEIN (GENOME POLYPROTEIN) 4 FMDV
other_details: STRAIN BFS, 1860
Source :
mol_id organism_scientific
1 Foot-and-mouth disease virus  (taxid:12110)
other_details: GROWN IN BHK CELLS
mol_id organism_scientific
2 Foot-and-mouth disease virus  (taxid:12110)
other_details: GROWN IN BHK CELLS
mol_id organism_scientific
3 Foot-and-mouth disease virus  (taxid:12110)
other_details: GROWN IN BHK CELLS
mol_id organism_scientific
4 Foot-and-mouth disease virus  (taxid:12110)
other_details: GROWN IN BHK CELLS
Authors : Fry, E.E., Lea, S.M., Jackson, T., Newman, J.W.I., Ellard, F.M., Blakemore, W.E., Abu-Ghazaleh, R., Samuel, A., King, A.M.Q., Stuart, D.I.
Keywords : VIRUS, HEPARAN SULPHATE, VIRUS-RECEPTOR INTERACTIONS/PROTEIN-CARBOHYDRATE INTERACTIONS, VIRUS/VIRAL PROTEIN, Icosahedral virus
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex.

Fry, E.E.,Lea, S.M.,Jackson, T.  et al.
(1999)  EMBO J.  18 : 543 - 554

PubMed: 9927414
DOI: 10.1093/emboj/18.3.543

Structure of a Major Immunogenic Site on Foot-and-Mouth Disease Virus

Logan, D.,Abu-Ghazaleh, R.,Blakemore, W.  et al.
(1993)  Nature  362 : 566

DOI: 10.1038/362566a0

The Three-Dimensional Structure of Foot-and-Mouth Disease Virus at 2.9 Angstroms Resolution

Acharya, R.,Fry, E.,Stuart, D.  et al.
(1989)  Nature  337 : 709

DOI: 10.1038/337709a0

Reaction

Chain : 4
UniProt : P03305 (POLG_FMDVO)
Reaction: EC: Evidence:
Physiological Direction:
Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|- Arg- and -Lys-|-Arg-. 3.4.22.46 -
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a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 3.6.1.15 -
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a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.48 PROSITE-ProRule:PRU00539
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Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. 3.4.22.28 PROSITE-ProRule:PRU01222
-