Het-PDB Navi2 (PDB: 1PO2)

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Ligands
Code	Name		Style	Show	Link
J77	(methylpyridazine piperidine ethyloxyphenyl)ethylacetate				PoSSuM
MYR	Myristic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1PO2

Code :

1PO2 PDBj RCSB PDB PDBe

Header :

VIRUS

Title :

POLIOVIRUS (TYPE 1, MAHONEY) IN COMPLEX WITH R77975, AN INHIBITOR OF VIRAL REPLICATION

Release Data :

1997-12-03

Compound :

mol_id	molecule	chains	synonym
1	POLIOVIRUS TYPE 1 MAHONEY	0	P1/MAHONEY

mol_id	molecule	chains	synonym
2	POLIOVIRUS TYPE 1 MAHONEY	1	P1/MAHONEY

mol_id	molecule	chains	synonym
3	POLIOVIRUS TYPE 1 MAHONEY	2	P1/MAHONEY

mol_id	molecule	chains	synonym
4	POLIOVIRUS TYPE 1 MAHONEY	3	P1/MAHONEY

mol_id	molecule	chains	synonym
5	POLIOVIRUS TYPE 1 MAHONEY	4	P1/MAHONEY

Source :

mol_id	organism_scientific
1	Human poliovirus 1 (taxid:12081)
	strain: Mahoney other_details: P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY MARIE CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME. THE ANTIVIRAL COMPOUND R77975 WAS DEVELOPED BY JANSSEN PHARMACEUTICA.

mol_id	organism_scientific
2	Human poliovirus 1 (taxid:12081)
	strain: Mahoney cell_line: HELA other_details: P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY MARIE CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME. THE ANTIVIRAL COMPOUND R77975 WAS DEVELOPED BY JANSSEN PHARMACEUTICA.

mol_id	organism_scientific
3	Human poliovirus 1 (taxid:12081)
	strain: Mahoney cell_line: HELA other_details: P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY MARIE CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME. THE ANTIVIRAL COMPOUND R77975 WAS DEVELOPED BY JANSSEN PHARMACEUTICA.

mol_id	organism_scientific
4	Human poliovirus 1 (taxid:12081)
	strain: Mahoney cell_line: HELA other_details: P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY MARIE CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME. THE ANTIVIRAL COMPOUND R77975 WAS DEVELOPED BY JANSSEN PHARMACEUTICA.

mol_id	organism_scientific
5	Human poliovirus 1 (taxid:12081)
	strain: Mahoney cell_line: HELA other_details: P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY MARIE CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME. THE ANTIVIRAL COMPOUND R77975 WAS DEVELOPED BY JANSSEN PHARMACEUTICA.

Authors :

Hiremath, C.N., Filman, D.J., Grant, R.A., Hogle, J.M.

Keywords :

POLIOVIRUS, PICORNAVIRUS COAT PROTEIN, ANTI-VIRAL DRUGS, HYDROLASE, THIOL PROTEASE, Icosahedral virus, Virus

Exp. method :

X-RAY DIFFRACTION ( 2.9 Å )

Citation :

Ligand-induced conformational changes in poliovirus-antiviral drug complexes.

Hiremath, C.N.,Filman, D.J.,Grant, R.A. et al.
(1997) Acta Crystallogr.,Sect.D 53 : 558 - 570

PubMed: 15299887
DOI: 10.1107/S0907444997000954

Binding of the Antiviral Drug Win51711 to the Sabin Strain of Type 3 Poliovirus: Structural Comparison with Drug Binding in Rhinovirus 14

Hiremath, C.N.,Grant, R.A.,Filman, D.J. et al.
(1995) Acta Crystallogr.,Sect.D 51 : 473

Structures of Poliovirus Complexes with Anti-Viral Drugs: Implications for Viral Stability and Drug Design

Grant, R.A.,Hiremath, C.N.,Filman, D.J. et al.
(1994) Curr.Biol. 4 : 784

Role of Conformational Transitions in Poliovirus Assembly and Cell Entry

Hogle, J.M.,Syed, R.,Fricks, C.E. et al.
(1990) New Aspects of Positive-Strand RNA Viruses : 199

Structural Factors that Control Conformational Transitions and Serotype Specificity in Type 3 Poliovirus

Filman, D.J.,Syed, R.,Chow, M. et al.
(1989) Embo J. 8 : 1567

Myristylation of Picornavirus Capsid Protein Vp4 and its Structural Significance

Chow, M.,Newman, J.F.,Filman, D. et al.
(1987) Nature 327 : 482

Three-Dimensional Structure of Poliovirus at 2.9 A Resolution

Hogle, J.M.,Chow, M.,Filman, D.J.
(1985) Science 229 : 1358

The Nucleotide Sequence of Poliovirus Type 3 Leon 12 A1B: Comparison with Poliovirus Type 1

Stanway, G.,Cann, A.J.,Hauptmann, R. et al.
(1983) Nucleic Acids Res. 11 : 5629

Chain :

UniProt :

P03300 (POLG_POL1M)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
[RNA-directed RNA polymerase] a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)	2.7.7.48	PROSITE-ProRule:PRU00539
	-	PROSITE-ProRule:PRU00539
[Protease 2A] Selective cleavage of Tyr-\|-Gly bond in the picornavirus polyprotein.	3.4.22.29	PubMed:1649327
	-	PubMed:1649327
[Protein 2C] a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate	3.6.1.15	PubMed:19520852, PubMed:30231078, PubMed:7730315, PubMed:8385138
	-
[Protease 3C] Selective cleavage of Gln-\|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.	3.4.22.28	PROSITE-ProRule:PRU01222, PubMed:8097606
	-	PROSITE-ProRule:PRU01222, PubMed:8097606

PDB ID: 1PO2

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