Brand  (β version)

PDB ID: 1NKM

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Ligands
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0FP N-(6-aminohexanoyl)-3-methyl-L-valyl-3-methyl-L-valyl-N~1~-[(2s,3s)-3-hydroxy-4-oxo-4-{[(1r)-1-phenylpropyl]amino}butan-2-yl]-N~4~,N~4~-dimethyl-L-aspartamide PoSSuM
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Structure summary

Code : 1NKM   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Complex structure of HCMV Protease and a peptidomimetic inhibitor
Release Data : 2003-02-11
Compound :
mol_id molecule chains synonym
1 Assemblin A,B Protease, Capsid assembly protein
ec: 3.4.21.97
mutation: A143Q
Source :
mol_id organism_scientific organism_common expression_system
1 Human herpesvirus 5  (taxid:10359) Human cytomegalovirus Escherichia coli  (taxid:562)
gene: UL80, APNG
Authors : Khayat, R., Batra, R., Qian, C., Halmos, T., Bailey, M., Tong, L.
Keywords : Protease, Peptidomimetic Inhibitor, Induced-fit, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Structural and Biochemical Studies of Inhibitor Binding to Human Cytomegalovirus Protease

Khayat, R.,Batra, R.,Qian, C.  et al.
(2003)  Biochemistry  42 : 885 - 891

PubMed: 12549906
DOI: 10.1021/bi027045s

Reaction

Chain : A, B
UniProt : P16753 (SCAF_HCMVA)
Reaction: EC: Evidence:
Physiological Direction:
[Assemblin]
Cleaves -Ala-|-Ser- and -Ala-|-Ala- bonds in the scaffold protein. 		3.4.21.97 HAMAP-Rule:MF_04008, PubMed:11371196
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