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Code Name Link
MC 1,2-cis-1-hydroxy-2,7-diamino-mitosene
Modified Residues
Code Name Link
MSE Selenomethionine
Code : 1KLL   PDBj   RCSB PDB   PDBe
Title : Molecular basis of mitomycin C resictance in streptomyces: Crystal structures of the MRD protein with and without a drug derivative
Release Data : 2002-07-19
Compound :
mol_id molecule chains synonym
1 mitomycin-binding protein A Mrd; Mitomycin resistance protein D
mutation: L19M, L25M
other_details: complexed with 2,7-DIAMINOMITOSENE, residue MC
Source :
mol_id organism_scientific expression_system
1 Streptomyces lavendulae  (taxid:1914) Escherichia coli  (taxid:562)
expression_system_strain: BL221(DE3)
expression_system_vector: pHis Paralell I
Authors : Martin, T.W., Dauter, Z., Devedjiev, Y., Sheffield, P., Jelen, F., He, M., Sherman, D., Otlewski, J., Derewenda, Z.S., Derewenda, U.
Keywords : Mitomycin C, antibiotic resistance, SAD, anomalous diffraction, domain swapping, p-staking, ANTIMICROBIAL PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein.

Martin, T.W.,Dauter, Z.,Devedjiev, Y.  et al.
(2002)  Structure  10 : 933 - 942

PubMed: 12121648
DOI: 10.1016/S0969-2126(02)00778-5

Chain : A
UniProt : O05205 (No found in current UniProtKB/SwissProt)
Reaction : -