PDB ID: 1KHQ
Hetero Atom Contents
color scheme of protein:
chain: Hide other chain(s)
Structure summary
Code : | 1KHQ PDBj RCSB PDB PDBe | ||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||||||||||
Title : | ORTHORHOMBIC FORM OF PAPAIN/ZLFG-DAM COVALENT COMPLEX | ||||||||||||||||||||
Release Data : | 2003-09-09 | ||||||||||||||||||||
Compound : |
|
||||||||||||||||||||
Source : |
|
||||||||||||||||||||
Authors : | Janowski, R., Kozak, M., Jankowska, E., Grzonka, Z., Jaskolski, M. | ||||||||||||||||||||
Keywords : | PROTEASE INHIBITOR, DIAZOMETHYLKETONE INHIBITOR, IRREVERSIBLE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX | ||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.6 Å ) | ||||||||||||||||||||
Citation : |
Two polymorphs of a covalent complex between papain and a diazomethylketone inhibitor
Janowski, R.,Kozak, M.,Jankowska, E.
et al.
PubMed: 15357669 Crystallization and preliminary crystallographic studies of a new crystal form of papain from Carica papaya.
Kozak, M.,Kozian, E.,Grzonka, Z.
et al.
Structural studies of cysteine proteases and their inhibitors
Grzonka, Z.,Jankowska, E.,Wieczerzak, E.
et al.
Binding of chloromethyl ketone substrate analogues to crystalline papain.
Drenth, J.,Kalk, K.H.,Swen, H.M.
Structure of monoclinic papain at 1.60 Angstroms resolution
Pickersgill, R.W.,Harris, G.W.,Garman, E.
Binding modes of a new epoxysuccinyl-peptide inhibitor of cysteine proteases. Where and how do cysteine proteases express their selectivity?
Czaplewski, C.,Grzonka, Z.,Jaskolski, M.
et al.
|
Reaction
Chain : | A |
---|---|
UniProt : | P00784 (PAPA1_CARPA) |
Reaction : | Reaction=Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1'.; EC=3.4.22.2; |