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Ligands
Code Name Link
FEP [(4-{4-[4-(difluoro-phosphono-methyl)-phenyl]-butyl}-phenyl)-difluoro-methyl]-phosphonic acid
Code : 1KAV   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Human Tyrosine Phosphatase 1B Complexed with an Inhibitor
Release Data : 2002-06-19
Compound :
mol_id molecule chains synonym
1 PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 A PROTEIN-TYROSINE PHOSPHATASE 1B
ec: 3.1.3.48
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Jia, Z., Ye, Q., Dinaut, A.N., Wang, Q., Waddleton, D., Payette, P., Ramachandran, C., Kennedy, B., Hum, G., Taylor, S.D.
Keywords : PROTEIN-INHIBITOR COMPLEX, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.35 Å )
Citation :

Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.

Jia, Z.,Ye, Q.,Dinaut, A.N.  et al.
(2001)  J.Med.Chem.  44 : 4584 - 4594

PubMed: 11741477
DOI: 10.1021/jm010266w

Chain : A
UniProt : P18031 (PTN1_HUMAN)
Reaction : Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE- ProRule:PRU10044};