Het-PDB Navi2 (PDB: 1GMN)

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Ligands
Code	Name		Link
EPE	4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid		PoSSuM
IDS	2-O-sulfo-alpha-L-idopyranuronic acid		PoSSuM
SGN	2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose		PoSSuM
		: Polysaccharide

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Download interaction data: 1GMN

Code :

1GMN PDBj RCSB PDB PDBe

Header :

HORMONE/GROWTH FACTOR

Title :

CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR

Release Data :

2001-10-02

Compound :

mol_id	molecule	chains	synonym
1	HEPATOCYTE GROWTH FACTOR	A,B	SCATTER FACTOR, SF, HEPATOPOEITIN A
	fragment: NK1 mutation: YES other_details: NK1 DIMER IN COMPLEX WITH HEPARIN MOLECULE

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	PICHIA PASTORIS (taxid:4922)
	expression_system_strain: GS115 expression_system_vector: YEAST expression_system_plasmid: PPIC-9K

Authors :

Lietha, D., Chirgadze, D.Y., Mulloy, B., Blundell, T.L., Gherardi, E.

Keywords :

HGF/SF, HORMONE/GROWTH FACTOR, HORMONE-GROWTH FACTOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.30 Å )

Citation :

Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor

Lietha, D.,Chirgadze, D.Y.,Mulloy, B. et al.
(2001) Embo J. 20 : 5543

PDB ID: 1GMN