Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
EPE 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid
Modified Residues
Code Name Link
IDS 2-O-sulfo-alpha-L-idopyranuronic acid
SGN 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose
Code : 1GMN   PDBj   RCSB PDB   PDBe
Header : HORMONE/GROWTH FACTOR
Title : CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR
Release Data : 2001-10-02
Compound :
mol_id molecule chains synonym
1 HEPATOCYTE GROWTH FACTOR A,B SCATTER FACTOR, SF, HEPATOPOEITIN A
fragment: NK1
mutation: YES
other_details: NK1 DIMER IN COMPLEX WITH HEPARIN MOLECULE
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN PICHIA PASTORIS  (taxid:4922)
expression_system_strain: GS115
expression_system_vector: YEAST
expression_system_plasmid: PPIC-9K
Authors : Lietha, D., Chirgadze, D.Y., Mulloy, B., Blundell, T.L., Gherardi, E.
Keywords : HGF/SF, HORMONE/GROWTH FACTOR, HORMONE-GROWTH FACTOR complex
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor

Lietha, D.,Chirgadze, D.Y.,Mulloy, B.  et al.
(2001)  Embo J.  20 : 5543

PubMed: 11597998
DOI: 10.1093/EMBOJ/20.20.5543

Chain : A, B
UniProt : P14210 (HGF_HUMAN)
Reaction : -