Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0GM N-[(5s,9s,10s,13s)-9-hydroxy-5,10-bis(2-methylpropyl)-4,7,12,16-tetraoxo-3,6,11,17-tetraazabicyclo[17.3.1]tricosa-1(23),19,21-trien-13-yl]-3-(naphthalen-1-yl)-2-(naphthalen-1-ylmethyl)propanamide
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modified Residues
Code Name Link
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
Code : 1FQ5   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : X-ray structure of a cyclic statine inhibitor PD-129,541 bound to yeast proteinase A
Release Data : 2000-09-20
Compound :
mol_id molecule chains synonym
1 SACCHAROPEPSIN A ASPARTATE PROTEASE, PROTEINASE A
ec: 3.4.23.25
Source :
mol_id organism_scientific organism_common
1 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
Authors : Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Keywords : HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.

Cronin, N.B.,Badasso, M.O.,J Tickle, I.  et al.
(2000)  J.Mol.Biol.  303 : 745 - 760

PubMed: 11061973
DOI: 10.1006/jmbi.2000.4181

The Three-dimensional Structure at 2.4 A Resolution of Glycosylated Proteinase A from the Lysosome-like Vacuole of Saccharomyces cerevisiae

Aguilar, C.F.,Cronin, N.B.,Badasso, M.  et al.
(1997)  J.Mol.Biol.  267 : 899 - 915

DOI: 10.1006/jmbi.1996.0880

Chain : A
UniProt : P07267 (CARP_YEAST)
Reaction : Reaction=Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu-|-Val-Tyr- bond in a synthetic substrate. Does not act on esters of Tyr or Arg.; EC=3.4.23.25;