Het-PDB Navi2 (PDB: 1F9E)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
ASA	Aspartic aldehyde

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
PHQ	Benzyl chlorocarbonate

Download interaction data: 1F9E

Code :

1F9E PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

CASPASE-8 SPECIFICITY PROBED AT SUBSITE S4: CRYSTAL STRUCTURE OF THE CASPASE-8-Z-DEVD-CHO

Release Data :

2001-07-10

Compound :

mol_id	molecule	chains
1	CASPASE-8 ALPHA CHAIN	A,C,E,G,I,K
	ec: 3.4.22.-

mol_id	molecule	chains
2	CASPASE-8 BETA CHAIN	B,D,F,H,J,L

mol_id	molecule	chains
3	(PHQ)DEVD	Q,R,S,T,U,V

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	expression_system_vector_type: PLASMID expression_system_plasmid: PET21B

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	expression_system_vector_type: PLASMID expression_system_plasmid: PET21B

mol_id	organism_scientific
3
	synthetic: yes other_details: chemically synthesized

Authors :

Blanchard, H., Donepudi, M., Tschopp, M., Kodandapani, L., Wu, J.C., Grutter, M.G.

Keywords :

CYSTEINE PROTEASE, CASPASE-8, FLICE, MCH5, MACH, APOPTOSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.9 Å )

Citation :

Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex.

Blanchard, H.,Donepudi, M.,Tschopp, M. et al.
(2000) J.Mol.Biol. 302 : 9 - 16

PubMed: 10964557
DOI: 10.1006/jmbi.2000.4041

The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis

Blanchard, H.,Kodandapani, L.,Mittl, P.R.E. et al.
(1999) Structure 7 : 1125 - 1133

DOI: 10.1016/S0969-2126(99)80179-8

The atomic-resolution of human caspase-8, a key activator of apoptosis.

Watt, W.,Koeplinger, K.A.,Mildner, A.M. et al.
(1999) Structure 7 : 1135 - 1143

DOI: 10.1016/S0969-2126(99)80180-4

Chain :

B, D, F, H, J, L

UniProt :

Q14790 (CASP8_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-\|-(Gly/Ser/Ala).	3.4.22.61	PubMed:16916640, PubMed:23516580, PubMed:32929201, PubMed:34012073, PubMed:8962078
	-

PDB ID: 1F9E

Hetero Atom Contents

Structure summary

Reaction