Brand  (β version)

PDB ID: 1DNU

Hetero Atom Contents

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Code Name Style Show Link
SCN Thiocyanate ion PoSSuM
SO4 Sulfate ion PoSSuM
CA Calcium ion PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
ACY Acetic acid PoSSuM

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Non-standard Residues
Code Name Show
CSO S-hydroxycysteine
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
FUC Alpha-L-fucopyranose
Modification
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Structure summary

Code : 1DNU   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : STRUCTURAL ANALYSES OF HUMAN MYELOPEROXIDASE-THIOCYANATE COMPLEX
Release Data : 2001-12-21
Compound :
mol_id molecule chains
1 MYELOPEROXIDASE A,B
ec: 1.11.1.7
fragment: MYELOPEROXIDASE LIGHT CHAIN CONTAINING RESIDUES 1 TO 104
mol_id molecule chains
2 MYELOPEROXIDASE C,D
ec: 1.11.1.7
fragment: MYELOPEROXIDASE HEAVY CHAIN CONTAINING RESIDUES 113 TO 578
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
tissue: BLOOD
cell: NEUTROPHIL
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
tissue: BLOOD
cell: NEUTROPHIL
Authors : Blair-Johnson, M., Fiedler, T.J., Fenna, R.E.
Keywords : oxidoreductase, peroxidase, inhibitor complex thiocyanate, halide peroxidation, neutrophil
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 A resolution.

Blair-Johnson, M.,Fiedler, T.,Fenna, R.
(2001)  Biochemistry  40 : 13990 - 13997

PubMed: 11705390
DOI: 10.1021/bi0111808

Reaction

Chain : C, D
UniProt : P05164 (PERM_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
chloride + H2O2 + H(+) = hypochlorous acid + H2O 1.11.2.2 PubMed:16125131, PubMed:17074761, PubMed:17438335, PubMed:19608745, PubMed:21880720, PubMed:22131345, PubMed:22902565, PubMed:24194519, PubMed:9359420, PubMed:9922160
left-to-right PubMed:16125131, PubMed:17074761, PubMed:17438335, PubMed:19608745, PubMed:21880720, PubMed:22131345, PubMed:22902565, PubMed:24194519
thiocyanate + H2O2 + H(+) = hypothiocyanous acid + H2O - PubMed:16125131, PubMed:6295491
left-to-right
bromide + H2O2 = hypobromite + H2O - PubMed:16125131, PubMed:17438335
left-to-right
iodide + H2O2 = hypoiodite + H2O - PubMed:1318692
left-to-right
Cofactor: Evidence: Note:
Ca(2+) ECO:0000269 | PubMed:10766826
ECO:0000269 | PubMed:11705390
ECO:0000269 | PubMed:19608745
ECO:0000269 | PubMed:21880720
ECO:0000269 | PubMed:22352991
ECO:0000269 | PubMed:28348079
ECO:0000269 | PubMed:28808028
ECO:0000269 | PubMed:29306874
ECO:0000269 | PubMed:36150500
ECO:0000269 | PubMed:40963017
ECO:0000269 | PubMed:7840679
Binds 1 Ca(2+) ion per monomer.
heme b ECO:0000269 | PubMed:17438335
ECO:0000269 | PubMed:19608745
ECO:0000269 | PubMed:21880720
ECO:0000269 | PubMed:22352991
ECO:0000269 | PubMed:23843990
ECO:0000269 | PubMed:28348079
ECO:0000269 | PubMed:40963017
ECO:0000269 | PubMed:7840679
Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer.