Brand  (β version)

PDB ID: 1D1S

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
ACT Acetate ion PoSSuM
CAC Cacodylate ion PoSSuM
NAD Nicotinamide-adenine-dinucleotide PoSSuM
Non-standard Residues
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Structure summary

Code : 1D1S   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : WILD-TYPE HUMAN SIGMA (CLASS IV) ALCOHOL DEHYDROGENASE
Release Data : 1999-09-29
Compound :
mol_id molecule chains synonym
1 ALCOHOL DEHYDROGENASE CLASS IV SIGMA CHAIN A,B,C,D RETINOL DEHYDROGENASE, GASTRIC ALCOHOL DEHYDROGENASE
ec: 1.1.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_vector: PKK223-3 AMPICILLIN SELECTABLE VECTOR FROM PHARMACIA
Authors : Xie, P.T., Hurley, T.D.
Keywords : ROSSMAN OR DINUCLEOTIDE FOLD, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase.

Xie, P.T.,Hurley, T.D.
(1999)  Protein Sci.  8 : 2639 - 2644

PubMed: 10631979

X-ray structure of human class IV sigma-sigma alcohol dehydrogenase

Xie, P.T.,Parsons, S.H.,Speckhard, D.C.  et al.
(1997)  J.Biol.Chem.  272 : 18558 - 18563

DOI: 10.1074/jbc.272.30.18558

Reaction

Chain : A, B, C, D
UniProt : P40394 (ADH7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a primary alcohol + NAD(+) = an aldehyde + NADH + H(+) 1.1.1.1 PubMed:9600267
right-to-left
10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + NADH + H(+) 1.1.1.66 PubMed:9600267
left-to-right
all-trans-retinol + NAD(+) = all-trans-retinal + NADH + H(+) 1.1.1.105 PubMed:15369820, PubMed:16787387, PubMed:9600267
left-to-right PubMed:16787387
9-cis-retinol + NAD(+) = 9-cis-retinal + NADH + H(+) - PubMed:9600267
left-to-right
all-trans-3,4-didehydroretinol + NAD(+) = all-trans-3,4- didehydroretinal + NADH + H(+) - PubMed:15369820
left-to-right
all-trans-4-hydroxyretinol + NAD(+) = all-trans-4- hydroxyretinal + NADH + H(+) - PubMed:15369820
left-to-right
all-trans-4-oxoretinol + NAD(+) = all-trans-4-oxoretinal + NADH + H(+) - PubMed:15369820
right-to-left
12-hydroxydodecanoate + NAD(+) = 12-oxododecanoate + NADH + H(+) - PubMed:9600267
left-to-right
16-hydroxyhexadecanoate + NAD(+) = 16-oxohexadecanoate + NADH + H(+) - PubMed:9600267
left-to-right
hexan-1-ol + NAD(+) = hexanal + NADH + H(+) - PubMed:9600267
right-to-left
(E)-hex-2-en-1-ol + NAD(+) = (E)-hex-2-enal + NADH + H(+) - PubMed:9600267
right-to-left
(E)-4-hydroxynon-2-en-1-ol + NAD(+) = (E)-4-hydroxynon-2-enal + NADH + H(+) - PubMed:9600267
right-to-left
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:10631979
Binds 2 Zn(2+) ions per subunit.