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Ligands
Code Name Link
ACT Acetate ion
CAC Cacodylate ion
NAD Nicotinamide-adenine-dinucleotide
ZN Zinc ion
Code : 1D1S   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : WILD-TYPE HUMAN SIGMA (CLASS IV) ALCOHOL DEHYDROGENASE
Release Data : 1999-09-29
Compound :
mol_id molecule chains synonym
1 ALCOHOL DEHYDROGENASE CLASS IV SIGMA CHAIN A,B,C,D RETINOL DEHYDROGENASE, GASTRIC ALCOHOL DEHYDROGENASE
ec: 1.1.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_vector: PKK223-3 AMPICILLIN SELECTABLE VECTOR FROM PHARMACIA
Authors : Xie, P.T., Hurley, T.D.
Keywords : ROSSMAN OR DINUCLEOTIDE FOLD, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase.

Xie, P.T.,Hurley, T.D.
(1999)  Protein Sci.  8 : 2639 - 2644

PubMed: 10631979

X-ray structure of human class IV sigma-sigma alcohol dehydrogenase

Xie, P.T.,Parsons, S.H.,Speckhard, D.C.  et al.
(1997)  J.Biol.Chem.  272 : 18558 - 18563

DOI: 10.1074/jbc.272.30.18558

Chain : A, B, C, D
UniProt : P40394 (ADH7_HUMAN)
Reaction : Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH; Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1; Evidence={ECO:0000269|PubMed:9600267}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10737; Evidence={ECO:0000305|PubMed:9600267}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:10738; Evidence={ECO:0000305|PubMed:9600267};
Reaction=10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH; Xref=Rhea:RHEA:20880, ChEBI:CHEBI:11305, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58022; EC=1.1.1.66; Evidence={ECO:0000269|PubMed:9600267}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20881; Evidence={ECO:0000305|PubMed:9600267};
Reaction=all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH; Xref=Rhea:RHEA:21284, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.105; Evidence={ECO:0000269|PubMed:15369820, ECO:0000269|PubMed:16787387, ECO:0000269|PubMed:9600267}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21285; Evidence={ECO:0000305|PubMed:16787387};
Reaction=9-cis-retinol + NAD(+) = 9-cis-retinal + H(+) + NADH; Xref=Rhea:RHEA:42052, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78272, ChEBI:CHEBI:78273; Evidence={ECO:0000269|PubMed:9600267}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42053; Evidence={ECO:0000305|PubMed:9600267};
Reaction=all-trans-3,4-didehydroretinol + NAD(+) = all-trans-3,4- didehydroretinal + H(+) + NADH; Xref=Rhea:RHEA:55940, ChEBI:CHEBI:15378, ChEBI:CHEBI:28537, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132246; Evidence={ECO:0000269|PubMed:15369820}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55941; Evidence={ECO:0000305|PubMed:15369820};
Reaction=all-trans-4-hydroxyretinol + NAD(+) = all-trans-4- hydroxyretinal + H(+) + NADH; Xref=Rhea:RHEA:55936, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132259, ChEBI:CHEBI:139346; Evidence={ECO:0000269|PubMed:15369820}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55937; Evidence={ECO:0000305|PubMed:15369820};
Reaction=all-trans-4-oxoretinol + NAD(+) = all-trans-4-oxoretinal + H(+) + NADH; Xref=Rhea:RHEA:60632, ChEBI:CHEBI:15378, ChEBI:CHEBI:44597, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:139347; Evidence={ECO:0000269|PubMed:15369820}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:60634; Evidence={ECO:0000305|PubMed:15369820};
Reaction=12-hydroxydodecanoate + NAD(+) = 12-oxododecanoate + H(+) + NADH; Xref=Rhea:RHEA:60980, ChEBI:CHEBI:15378, ChEBI:CHEBI:36204, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:144067; Evidence={ECO:0000269|PubMed:9600267}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60981; Evidence={ECO:0000305|PubMed:9600267};
Reaction=16-hydroxyhexadecanoate + NAD(+) = 16-oxohexadecanoate + H(+) + NADH; Xref=Rhea:RHEA:60984, ChEBI:CHEBI:15378, ChEBI:CHEBI:55329, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:144068; Evidence={ECO:0000269|PubMed:9600267}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60985; Evidence={ECO:0000305|PubMed:9600267};
Reaction=hexan-1-ol + NAD(+) = H(+) + hexanal + NADH; Xref=Rhea:RHEA:60972, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:87393, ChEBI:CHEBI:88528; Evidence={ECO:0000269|PubMed:9600267}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60973; Evidence={ECO:0000305|PubMed:9600267}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:60974; Evidence={ECO:0000305|PubMed:9600267};
Reaction=(E)-hex-2-en-1-ol + NAD(+) = (E)-hex--2-enal + H(+) + NADH; Xref=Rhea:RHEA:60988, ChEBI:CHEBI:15378, ChEBI:CHEBI:28913, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:141205; Evidence={ECO:0000269|PubMed:9600267}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60989; Evidence={ECO:0000305|PubMed:9600267}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:60990; Evidence={ECO:0000305|PubMed:9600267};
Reaction=(E)-4-hydroxynon-2-en-1-ol + NAD(+) = (E)-4-hydroxynon-2-enal + H(+) + NADH; Xref=Rhea:RHEA:60976, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58968, ChEBI:CHEBI:142617; Evidence={ECO:0000269|PubMed:9600267}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:60978; Evidence={ECO:0000305|PubMed:9600267};