Het-PDB Navi2 (PDB: 1CKP)

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Ligands
Code	Name		Style	Show	Link
EDO	1,2-ethanediol				PoSSuM
PVB	Purvalanol B				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1CKP

Code :

1CKP PDBj RCSB PDB PDBe

Header :

HORMONE/GROWTH FACTOR

Title :

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR PURVALANOL B

Release Data :

1999-01-13

Compound :

mol_id	molecule	chains	synonym
1	PROTEIN (CYCLIN-DEPENDENT PROTEIN KINASE 2)	A	CDK2
	ec: 2.7.1.37

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	cell_line: SF9 expression_system_common: Fall armyworm expression_system_cell_line: SF9 expression_system_vector: BACULOVIRUS

Authors :

Gray, N.S., Thunnissen, A.M.W.H., Schultz, P.G., Kim, S.H.

Keywords :

PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION, HORMONE-GROWTH FACTOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.05 Å )

Citation :

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.

Gray, N.S.,Wodicka, L.,Thunnissen, A.M. et al.
(1998) Science 281 : 533 - 538

PubMed: 9677190
DOI: 10.1126/science.281.5376.533

Inhibition of Cyclin-Dependent Kinases by Purine Analogues-Crystal Structure of Human Cdk2 Complexed with Roscovitine

De Azevedo, W.F.,Leclerc, S.,Meijer, L. et al.
(1997) Eur.J.Biochem. 243 : 518

Multiple Modes of Ligand Recognition: Crystal Structures of Cyclin-Dependent Protein Kinase 2 in Complex with ATP and Two Inhibitors, Olomoucine and Isopentenyladenine

Schultze-Gahmen, U.,Brandsen, J.,Jones, H.D. et al.
(1995) Protein Sci. 22 : 378

Crystal Structure of Cyclin-Dependent Kinase 2

De Bondt, H.L.,Rosenblatt, J.,Jancarik, J. et al.
(1993) Nature 363 : 595

Chain :

UniProt :

P24941 (CDK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.22	PubMed:1396589, PubMed:28666995, PubMed:9030781
	-	PubMed:1396589, PubMed:28666995, PubMed:9030781
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.22	PubMed:1396589, PubMed:28666995, PubMed:9030781
	-	PubMed:1396589, PubMed:28666995, PubMed:9030781

PDB ID: 1CKP

Hetero Atom Contents

Structure summary

Reaction