Het-PDB Navi2 (PDB: 1BPJ)

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Ligands
Code	Name		Style	Show	Link
K	Potassium ion				PoSSuM
UMP	2'-deoxyuridine 5'-monophosphate				PoSSuM

Non-standard Residues
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Download interaction data: 1BPJ

Code :

1BPJ PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

THYMIDYLATE SYNTHASE R178T, R179T DOUBLE MUTANT

Release Data :

1998-08-19

Compound :

mol_id	molecule	chains
1	PROTEIN (THYMIDYLATE SYNTHASE)	A
	ec: 2.1.1.45 mutation: R178T, R179T

Source :

mol_id	organism_scientific	expression_system
1	Lactobacillus casei (taxid:1582)	Escherichia coli (taxid:562)
	strain: E. COLI CHI-2913 expression_system_strain: CHI-2913 expression_system_plasmid: PKPTSD other_details: SYNTHETIC GENE

Authors :

Morse, R.J., Finer-Moore, J.S., Stroud, R.M.

Keywords :

TRANSFERASE (METHYLTRANSFERASE), TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS

Exp. method :

X-RAY DIFFRACTION ( 2.4 Å )

Citation :

Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".

Morse, R.J.,Kawase, S.,Santi, D.V. et al.
(2000) Biochemistry 39 : 1011 - 1020

PubMed: 10653645
DOI: 10.1021/bi9918590

Stereochemistry of a Multistep(Slash)Bipartite Methyl Transfer Reaction: Thymidylate Synthase

Stroud, R.M.,Finer-Moore, J.S.
(1993) Faseb J. 7 : 671

Refined Structures of Substrate-Bound and Phosphate-Bound Thymidylate Synthase from Lactobacillus Casei

Finer-Moore, J.S.,Fauman, E.B.,Foster, P.G. et al.
(1993) J.Mol.Biol. 232 : 1101

Atomic Structure of Thymidylate Synthase: Target for Rational Drug Design

Hardy, L.W.,Finer-Moore, J.S.,Montfort, W.R. et al.
(1987) Science 235 : 448

Chain :

UniProt :

P00469 (TYSY_LACCA)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8- dihydrofolate + dTMP	2.1.1.45	HAMAP-Rule:MF_00008
	-	HAMAP-Rule:MF_00008

PDB ID: 1BPJ

Hetero Atom Contents

Structure summary

Reaction