PDB ID: 1BPJ
Hetero Atom Contents
color scheme of protein:
hetatm:
chain:
Structure summary
Code : | 1BPJ PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | THYMIDYLATE SYNTHASE R178T, R179T DOUBLE MUTANT | ||||||||||||
Release Data : | 1998-08-19 | ||||||||||||
Compound : |
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Source : |
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Authors : | Morse, R.J., Finer-Moore, J.S., Stroud, R.M. | ||||||||||||
Keywords : | TRANSFERASE (METHYLTRANSFERASE), TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.4 Å ) | ||||||||||||
Citation : |
Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Morse, R.J.,Kawase, S.,Santi, D.V.
et al.
PubMed: 10653645 Stereochemistry of a Multistep(Slash)Bipartite Methyl Transfer Reaction: Thymidylate Synthase
Stroud, R.M.,Finer-Moore, J.S.
Refined Structures of Substrate-Bound and Phosphate-Bound Thymidylate Synthase from Lactobacillus Casei
Finer-Moore, J.S.,Fauman, E.B.,Foster, P.G.
et al.
Atomic Structure of Thymidylate Synthase: Target for Rational Drug Design
Hardy, L.W.,Finer-Moore, J.S.,Montfort, W.R.
et al.
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Reaction
Chain : | A |
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UniProt : | P00469 (TYSY_LACCA) |
Reaction : | Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP; Xref=Rhea:RHEA:12104, ChEBI:CHEBI:15636, ChEBI:CHEBI:57451, ChEBI:CHEBI:63528, ChEBI:CHEBI:246422; EC=2.1.1.45; Evidence={ECO:0000255|HAMAP-Rule:MF_00008}; |