Het-PDB Navi2 (PDB: 1AXM)

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Ligands
Code	Name		Link
SGN	2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose		PoSSuM
IDS	2-O-sulfo-alpha-L-idopyranuronic acid		PoSSuM
		: Polysaccharide

Non-standard Residues
Code	Name	Show
MSE	Selenomethionine

Glycosylation
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Download interaction data: 1AXM

Code :

1AXM PDBj RCSB PDB PDBe

Header :

GROWTH FACTOR

Title :

HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR

Release Data :

1998-04-22

Compound :

mol_id	molecule	chains	synonym
1	ACIDIC FIBROBLAST GROWTH FACTOR	A,B,C,D,E,F	FGF-1
	other_details: FOR EACH OF THE DECASACCHARIDE CHAINS IN THE ASYMMETRIC UNIT, FIVE MONOSACCHARIDE UNITS ARE DISORDERED

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	cell_line: JM109 DE3 organ: BRAIN STEM tissue: NERVE cell: ENDOTHELIAL cellular_location: EXTRACELLULAR MATRIX gene: ECGF expression_system_strain: JM109 expression_system_cell_line: JM109 DE3 expression_system_cellular_location: CYTOPLASM expression_system_vector_type: BACTERIAL expression_system_vector: ESCHERICHIA COLI expression_system_plasmid: PET-3A

Authors :

DiGabriele, A.D., Lax, I., Chen, D.I., Svahn, C.M., Jaye, M., Schlessinger, J., Hendrickson, W.A.

Keywords :

HUMAN ACIDIC FIBROBLAST GROWTH FACTOR, HEPARIN DECASACCHARIDE, GROWTH FACTOR

Exp. method :

X-RAY DIFFRACTION ( 3.00 Å )

Citation :

Structure of a heparin-linked biologically active dimer of fibroblast growth factor.

DiGabriele, A.D.,Lax, I.,Chen, D.I. et al.
(1998) Nature 393 : 812 - 817

X-ray crystal structure of human acidic fibroblast growth factor.

Blaber, M.,DiSalvo, J.,Thomas, K.A.
(1996) Biochemistry 35 : 2086 - 2094

Heparin Structure and Interactions with Basic Fibroblast Growth Factor

Faham, S.,Hileman, R.E.,Fromm, J.R. et al.
(1996) Science 271 : 1116

Structural Studies of the Binding of the Anti-Ulcer Drug Sucrose Octasulfate to Acidic Fibroblast Growth Factor

Zhu, X.,Hsu, B.T.,Rees, D.C.
(1993) Structure 1 : 27

PDB ID: 1AXM