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Modified Residues
Code Name Link
IDS 2-O-sulfo-alpha-L-idopyranuronic acid
MSE Selenomethionine
SGN 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose
Code : 1AXM   PDBj   RCSB PDB   PDBe
Header : GROWTH FACTOR
Title : HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR
Release Data : 1998-04-22
Compound :
mol_id molecule chains synonym
1 ACIDIC FIBROBLAST GROWTH FACTOR A,B,C,D,E,F FGF-1
other_details: FOR EACH OF THE DECASACCHARIDE CHAINS IN THE ASYMMETRIC UNIT, FIVE MONOSACCHARIDE UNITS ARE DISORDERED
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
cell_line: JM109 DE3
organ: BRAIN STEM
tissue: NERVE
cell: ENDOTHELIAL
cellular_location: EXTRACELLULAR MATRIX
gene: ECGF
expression_system_strain: JM109
expression_system_cell_line: JM109 DE3
expression_system_cellular_location: CYTOPLASM
expression_system_vector_type: BACTERIAL
expression_system_vector: ESCHERICHIA COLI
expression_system_plasmid: PET-3A
Authors : DiGabriele, A.D., Lax, I., Chen, D.I., Svahn, C.M., Jaye, M., Schlessinger, J., Hendrickson, W.A.
Keywords : HUMAN ACIDIC FIBROBLAST GROWTH FACTOR, HEPARIN DECASACCHARIDE, GROWTH FACTOR
Exp. method : X-RAY DIFFRACTION ( 3.00 Å )
Citation :

Structure of a heparin-linked biologically active dimer of fibroblast growth factor.

DiGabriele, A.D.,Lax, I.,Chen, D.I.  et al.
(1998)  Nature  393 : 812 - 817

PubMed: 9655399
DOI: 10.1038/31741

X-ray crystal structure of human acidic fibroblast growth factor.

Blaber, M.,DiSalvo, J.,Thomas, K.A.
(1996)  Biochemistry  35 : 2086 - 2094

PubMed: 8652550
DOI: 10.1021/bi9521755

Heparin Structure and Interactions with Basic Fibroblast Growth Factor

Faham, S.,Hileman, R.E.,Fromm, J.R.  et al.
(1996)  Science  271 : 1116

Structural Studies of the Binding of the Anti-Ulcer Drug Sucrose Octasulfate to Acidic Fibroblast Growth Factor

Zhu, X.,Hsu, B.T.,Rees, D.C.
(1993)  Structure  1 : 27

Chain : A, B, C, D, E, F
UniProt : P05230 (FGF1_HUMAN)
Reaction : -