Brand  (β version)

PDB ID: 1AW5

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
Non-standard Residues
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MSE Selenomethionine
Glycosylation
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Structure summary

Code : 1AW5   PDBj   RCSB PDB   PDBe
Header : DEHYDRATASE
Title : 5-AMINOLEVULINATE DEHYDRATASE FROM SACCHAROMYCES CEREVISIAE
Release Data : 1998-10-21
Compound :
mol_id molecule chains synonym
1 5-AMINOLEVULINATE DEHYDRATASE A PORPHOBILINOGEN SYNTHASE
ec: 4.2.1.24
mutation: M272V
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast Escherichia coli  (taxid:562)
cell_line: B834
cellular_location: CYTOSOL
gene: HEM2
expression_system_strain: B834 (DE3) PLYSS
expression_system_plasmid: PUC18
Authors : Erskine, P.T., Cooper, J.B., Wood, S.P.
Keywords : DEHYDRATASE, TETRAPYRROLE BIOSYNTHESIS, ALDOLASE, TIM-BARREL OCTAMER
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolase.

Erskine, P.T.,Senior, N.,Awan, S.  et al.
(1997)  Nat.Struct.Biol.  4 : 1025 - 1031

PubMed: 9406553
DOI: 10.1038/nsb1297-1025

Reaction

Chain : A
UniProt : P05373 (HEM2_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+) 4.2.1.24 -
-
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:10386874
Binds 1 zinc ion per monomer.