Brand  (β version)

PDB ID: 1AT0

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MSE Selenomethionine
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Structure summary

Code : 1AT0   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : 17-kDA fragment of hedgehog C-terminal autoprocessing domain
Release Data : 1997-11-12
Compound :
mol_id molecule chains
1 17-HEDGEHOG A
fragment: 17-KDA FRAGMENT OF C-TERMINAL DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Drosophila melanogaster FRUIT FLY Escherichia coli
cell_line: B834
expression_system_strain: B834 (DE3) PLYSS
expression_system_plasmid: PRSET B
Authors : Hall, T.M.T., Porter, J.A., Young, K.E., Koonin, E.V., Beachy, P.A., Leahy, D.J.
Keywords : DEVELOPMENTAL SIGNALING MOLECULE, CHOLESTEROL TRANSFER, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins.

Hall, T.M.,Porter, J.A.,Young, K.E.  et al.
(1997)  Cell(Cambridge,Mass.)  91 : 85 - 97

PubMed: 9335337
DOI: 10.1016/S0092-8674(01)80011-8

Reaction

Chain : A
UniProt : Q02936 (HH_DROME)
Reaction: EC: Evidence:
Physiological Direction:
[Protein hedgehog]
glycyl-L-cysteinyl-[protein] + cholesterol + H(+) = [protein]- C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl- [protein] 		- UniProtKB:Q62226
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