Het-PDB Navi2 (PDB: 1AOU)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine

Glycosylation
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Download interaction data: 1AOU

Code :

1AOU PDBj RCSB PDB PDBe

Header :

COMPLEX (PROTO-ONCOGENE/EARLY PROTEIN)

Title :

NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, 22 STRUCTURES

Release Data :

1998-01-14

Compound :

mol_id	molecule	chains	synonym
1	FYN PROTEIN-TYROSINE KINASE	F	SRC HOMOLOGY 2 DOMAIN
	ec: 2.7.1.112 fragment: SH2 DOMAIN mutation: C97S, C98S, C104S

mol_id	molecule	chains
2	PHOSPHOTYROSYL PEPTIDE	P

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	cell_line: BL21 gene: LYSS expression_system_strain: BL21 (DE3) expression_system_cellular_location: CYTOPLASM expression_system_plasmid: PRK172 expression_system_gene: LYSS

mol_id	organism_scientific
2	Hamster polyomavirus (taxid:10626)

Authors :

Mulhern, T.D., Shaw, G.L., Morton, C.J., Day, A.J., Campbell, I.D.

Keywords :

SH2 DOMAIN, SIGNAL TRANSDUCTION, PEPTIDE COMPLEX, COMPLEX (PROTO-ONCOGENE-EARLY PROTEIN), COMPLEX (PROTO-ONCOGENE-EARLY PROTEIN) complex

Exp. method :

SOLUTION NMR

Citation :

The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.

Mulhern, T.D.,Shaw, G.L.,Morton, C.J. et al.
(1997) Structure 5 : 1313 - 1323

PubMed: 9351806
DOI: 10.1016/S0969-2126(97)00283-9

Solution Studies of the Sh2 Domain from the Fyn Tyrosine Kinase: Secondary Structure, Backbone Dynamics and Protein Association

Pintar, A.,Hensmann, M.,Jumel, K. et al.
(1996) Eur.Biophys.J. 24 : 371

Chain :	P
UniProt :	P03079 (MT_POVHA)
Reaction :	-

PDB ID: 1AOU

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