Het-PDB Navi2 (PDB: 1AOB)

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Ligands
Code	Name	Link
DDU	2'-5'dideoxyuridine	PoSSuM
FMT	Formic acid	PoSSuM
PO4	Phosphate ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1AOB

Code :

1AOB PDBj RCSB PDB PDBe

Header :

METHYLTRANSFERASE

Title :

E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH DDURD

Release Data :

1998-07-01

Compound :

mol_id	molecule	chains	synonym
1	THYMIDYLATE SYNTHASE	A	TS, THYMIDYLATE SYNTHETASE
	ec: 2.1.1.45

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:562)
	cell_line: CHI-2913 gene: THYA expression_system_cell_line: CHI-2913 expression_system_vector: BLUESCRIPT expression_system_plasmid: PTHYA-WT expression_system_gene: THYA

Authors :

Stout, T.J., Sage, C.R., Stroud, R.M.

Keywords :

TRANSFERASE (METHYLTRANSFERASE), SUBSTRATE MODULES, METHYLTRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

The additivity of substrate fragments in enzyme-ligand binding.

Stout, T.J.,Sage, C.R.,Stroud, R.M.
(1998) Structure 6 : 839 - 848

Chain :

UniProt :

P0A884 (TYSY_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8- dihydrofolate + dTMP	2.1.1.45	HAMAP-Rule:MF_00008, PubMed:2223754, PubMed:3286637, PubMed:9826509
	-

PDB ID: 1AOB