Brand  (β version)

PDB ID: 1AHF

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Ligands
Code Name Style Show Link
IOP Indolylpropionic acid PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1AHF   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE (AMINOTRANSFERASE)
Title : ASPARTATE AMINOTRANSFERASE HEXAMUTANT
Release Data : 1995-09-15
Compound :
mol_id molecule chains synonym
1 ASPARTATE AMINOTRANSFERASE A,B ASPARTATE TRANSAMINASE
ec: 2.6.1.1
mutation: V39L, K41Y, T47I, N69L, T109S, N297S
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
Authors : Malashkevich, V.N., Jansonius, J.N.
Keywords : TRANSFERASE (AMINOTRANSFERASE)
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

Alternating arginine-modulated substrate specificity in an engineered tyrosine aminotransferase.

Malashkevich, V.N.,Onuffer, J.J.,Kirsch, J.F.  et al.
(1995)  Nat.Struct.Biol.  2 : 548 - 553

PubMed: 7664122
DOI: 10.1038/nsb0795-548

Redesign of Aspartate Aminotransferase Specificity to that of Tyrosine Aminotransferase

Kirsch, J.F.,Onuffer, J.J.
(1994)  Biochemistry of Vitamin B6 and Pqq  : 37

Reaction

Chain : A, B
UniProt : P00509 (AAT_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate 2.6.1.1 PubMed:10556573
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Cofactor: Evidence: Note:
pyridoxal 5'-phosphate ECO:0000269 | PubMed:11148029
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