Het-PDB Navi2 (PDB: 1AH5)

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Ligands
Code	Name		Style	Show	Link
DPM	3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1h-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1h-pyrrol-3-yl]propanoic acid				PoSSuM

Non-standard Residues
Code	Name	Show
MSE	Selenomethionine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 1AH5

Code :

1AH5 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

REDUCED FORM SELENOMETHIONINE-LABELLED HYDROXYMETHYLBILANE SYNTHASE DETERMINED BY MAD

Release Data :

1997-10-15

Compound :

mol_id	molecule	chains	synonym
1	HYDROXYMETHYLBILANE SYNTHASE	A	PORPHOBILINOGEN DEAMINASE
	ec: 2.5.1.61 fragment: THREE DOMAINS other_details: CONTAINS A DIPYRROMETHANE COFACTOR LINKED TO THE RESIDUE CYSTEINE 242

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:562)

Authors :

Helliwell, J.R., Nieh, Y.P., Harrop, S.J., Cassetta, A.

Keywords :

BIOSYNTHESIS OF LINEAR TETRAPYRROLE, ALL ALPHA/BETA, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.4 Å )

Citation :

Determination of the structure of seleno-methionine-labelled hydroxymethylbilane synthase in its active form by multi-wavelength anomalous dispersion.

Hadener, A.,Matzinger, P.K.,Battersby, A.R. et al.
(1999) Acta Crystallogr.,Sect.D 55 : 631 - 643

PubMed: 10089459
DOI: 10.1107/S0907444998014711

Chain :

UniProt :

P06983 (HEM3_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)	2.5.1.61	PubMed:3052434
4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)	-	PubMed:3052434
Cofactor:	Evidence:	Note:
dipyrromethane	-	Binds 1 dipyrromethane group covalently.

PDB ID: 1AH5

Hetero Atom Contents

Structure summary

Reaction