Brand  (β version)

PDB ID: 1AH5

Hetero Atom Contents

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
DPM 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1h-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1h-pyrrol-3-yl]propanoic acid PoSSuM
Modified Residues
Code Name Link
MSE Selenomethionine PoSSuM

Structure summary

Code : 1AH5   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : REDUCED FORM SELENOMETHIONINE-LABELLED HYDROXYMETHYLBILANE SYNTHASE DETERMINED BY MAD
Release Data : 1997-10-15
Compound :
mol_id molecule chains synonym
1 HYDROXYMETHYLBILANE SYNTHASE A PORPHOBILINOGEN DEAMINASE
ec: 2.5.1.61
fragment: THREE DOMAINS
other_details: CONTAINS A DIPYRROMETHANE COFACTOR LINKED TO THE RESIDUE CYSTEINE 242
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
Authors : Helliwell, J.R., Nieh, Y.P., Harrop, S.J., Cassetta, A.
Keywords : BIOSYNTHESIS OF LINEAR TETRAPYRROLE, ALL ALPHA/BETA, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

Determination of the structure of seleno-methionine-labelled hydroxymethylbilane synthase in its active form by multi-wavelength anomalous dispersion.

Hadener, A.,Matzinger, P.K.,Battersby, A.R.  et al.
(1999)  Acta Crystallogr.,Sect.D  55 : 631 - 643

PubMed: 10089459
DOI: 10.1107/S0907444998014711

Reaction

Chain : A
UniProt : P06983 (HEM3_ECOLI)
Reaction : Reaction=H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+); Xref=Rhea:RHEA:13185, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:57845, ChEBI:CHEBI:58126; EC=2.5.1.61;