Brand  (β version)

PDB ID: 1AD8

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Ligands
Code Name Style Show Link
MDL [dehydroxy-N-methyl-tyrosyl-prolinyl]-[4,4,5,5,5-pentafluoro-3-oxy-1-[3-indolyl]-pent-2-yl]amine PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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TYS O-sulfo-L-tyrosine
Glycosylation
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Structure summary

Code : 1AD8   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : COMPLEX OF THROMBIN WITH AND INHIBITOR CONTAINING A NOVEL P1 MOIETY
Release Data : 1997-11-12
Compound :
mol_id molecule chains
1 THROMBIN (SMALL SUBUNIT) L
ec: 3.4.21.5
mol_id molecule chains
2 THROMBIN (LARGE SUBUNIT) H
ec: 3.4.21.5
mol_id molecule chains
3 HIRUDIN (53-65) PEPTIDE I
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
tissue: BLOOD
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
tissue: BLOOD
mol_id organism_scientific organism_common
3 Hirudo medicinalis  (taxid:6421) Medicinal leech
Authors : Schreuder, H., Tardif, C., Malikayil, J.A.
Keywords : COMPLEX (SERINE PROTEASE-INHIBITOR), HYDROLASE, SERINE PROTEASE, COAGULANT, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.

Malikayil, J.A.,Burkhart, J.P.,Schreuder, H.A.  et al.
(1997)  Biochemistry  36 : 1034 - 1040

PubMed: 9033393
DOI: 10.1021/bi9622231

Reaction

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : I
UniProt : P01050 (HIRV1_HIRME)
Reaction : -