Het-PDB Navi2 (PDB: 1AD5)

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Ligands
Code	Name		Style	Show	Link
CA	Calcium ion				PoSSuM
ANP	Phosphoaminophosphonic acid-adenylate ester				PoSSuM

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 1AD5

Code :

1AD5 PDBj RCSB PDB PDBe

Header :

TYROSINE-PROTEIN KINASE

Title :

SRC FAMILY KINASE HCK-AMP-PNP COMPLEX

Release Data :

1997-05-15

Compound :

mol_id	molecule	chains
1	HAEMATOPOETIC CELL KINASE HCK	A,B
	ec: 2.7.1.112 fragment: SH3-SH2-KINASE-REGULATORY TAIL

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	cell_line: SF9 gene: HUMAN HCK expression_system_common: Fall armyworm expression_system_cell_line: SF9 expression_system_vector_type: BACULOVIRUS expression_system_gene: HUMAN HCK

Authors :

Sicheri, F., Moarefi, I., Kuriyan, J.

Keywords :

TYROSINE-PROTEIN KINASE, TRANSFERASE, SIGNAL TRANSDUCTION, SH2, SH3, PHOSPHORYLATION

Exp. method :

X-RAY DIFFRACTION ( 2.6 Å )

Citation :

Crystal structure of the Src family tyrosine kinase Hck.

Sicheri, F.,Moarefi, I.,Kuriyan, J.
(1997) Nature 385 : 602 - 609

Chain :

A, B

UniProt :

P08631 (HCK_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:10092522, PubMed:10779760, PubMed:15998323, PubMed:20810664, PubMed:7535819, PubMed:8064233, PubMed:8132624, PubMed:8995234
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PDB ID: 1AD5