Brand  (β version)

PDB ID: 1A7A

Hetero Atom Contents

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ADC (1'R,2'S)-9-(2-hydroxy-3'-keto-cyclopenten-1-yl)adenine PoSSuM
NAD Nicotinamide-adenine-dinucleotide PoSSuM

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Non-standard Residues
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MSE Selenomethionine
Glycosylation
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Structure summary

Code : 1A7A   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : STRUCTURE OF HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE: DETERMINATION OF A 30 SELENIUM ATOM SUBSTRUCTURE FROM DATA AT A SINGLE WAVELENGTH
Release Data : 1999-04-20
Compound :
mol_id molecule chains
1 S-ADENOSYLHOMOCYSTEINE HYDROLASE A,B
ec: 3.3.1.1
other_details: SELENOMETHIONINE DERIVATIZED PROTEIN
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
tissue: PLACENTA
expression_system_strain: B834
expression_system_cellular_location: CYTOPLASM
Authors : Turner, M.A., Yuan, C.-S., Borchardt, R.T., Hershfield, M.S., Smith, G.D., Howell, P.L.
Keywords : HYDROLASE, NAD BINDING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.8 Å )
Citation :

Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength.

Turner, M.A.,Yuan, C.S.,Borchardt, R.T.  et al.
(1998)  Nat.Struct.Biol.  5 : 369 - 376

PubMed: 9586999
DOI: 10.1038/nsb0598-369

Reaction

Chain : A, B
UniProt : P23526 (SAHH_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine 3.13.2.1 PubMed:10933798
left-to-right
Cofactor: Evidence: Note:
NAD(+) ECO:0000269 | PubMed:12590576
ECO:0000269 | PubMed:9586999
Binds 1 NAD(+) per subunit.