PDB ID: 1A5V
Hetero Atom Contents
color scheme of protein:
hetatm:
x
information
centroid:
interaction residue:
chain:
Structure summary
Code : | 1A5V PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE | ||||||||||||
Title : | ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3 AND MN CATION | ||||||||||||
Release Data : | 1998-05-27 | ||||||||||||
Compound : |
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Source : |
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Authors : | Lubkowski, J., Yang, F., Alexandratos, J., Wlodawer, A. | ||||||||||||
Keywords : | HYDROLASE, ENDONUCLEASE, HIV-1 INTEGRASE INHIBITOR | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.9 Å ) | ||||||||||||
Citation : |
Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.
Lubkowski, J.,Yang, F.,Alexandratos, J.
et al.
PubMed: 9560188 |
Reaction
Chain : | A |
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UniProt : | P03354 (POL_RSVP) |
Reaction : | Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.49; Evidence={ECO:0000255|PROSITE- ProRule:PRU00405}; Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7; Evidence={ECO:0000255|PROSITE- ProRule:PRU00405}; Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; Evidence={ECO:0000255|PROSITE-ProRule:PRU00408}; |