Het-PDB Navi2 (PDB: 1A5V)

color scheme of protein:

hetatm:

information

centroid:

interaction residue:

chain:

Ligands
Code	Name	Link
MN	Manganese (II) ion	PoSSuM
Y3	4-acetylamino-5-hydroxynaphthalene-2,7-disulfonic acid	PoSSuM

Download interaction data: 1A5V

Code :

1A5V PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3 AND MN CATION

Release Data :

1998-05-27

Compound :

mol_id	molecule	chains
1	INTEGRASE	A
	ec: 2.7.7.49 fragment: CATALYTIC CORE DOMAIN other_details: P03354 FRAGMENT OF POLYPROTEIN POL-RSVP

Source :

mol_id	organism_scientific	expression_system
1	Rous sarcoma virus (strain Schmidt-Ruppin) (taxid:11889)	Escherichia coli (taxid:562)
	strain: Schmidt-Ruppin expression_system_plasmid: PRC23IN(52-207) other_details: SEE JRNL REFERENCE

Authors :

Lubkowski, J., Yang, F., Alexandratos, J., Wlodawer, A.

Keywords :

HYDROLASE, ENDONUCLEASE, HIV-1 INTEGRASE INHIBITOR

Exp. method :

X-RAY DIFFRACTION ( 1.9 Å )

Citation :

Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.

Lubkowski, J.,Yang, F.,Alexandratos, J. et al.
(1998) Proc.Natl.Acad.Sci.USA 95 : 4831 - 4836

Chain :	A
UniProt :	P03354 (POL_RSVP)
Reaction :	Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.49; Evidence={ECO:0000255\|PROSITE- ProRule:PRU00405}; Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7; Evidence={ECO:0000255\|PROSITE- ProRule:PRU00405}; Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; Evidence={ECO:0000255\|PROSITE-ProRule:PRU00408};

PDB ID: 1A5V