Brand  (β version)

PDB ID: 1A4Q

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
DPC 5-acetylamino-4-amino-6-(phenethyl-propyl-carbamoyl)-5,6-dihydro-4h-pyran-2-carboxylic acid PoSSuM
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose PoSSuM
Non-standard Residues
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Structure summary

Code : 1A4Q   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : INFLUENZA VIRUS B/BEIJING/1/87 NEURAMINIDASE COMPLEXED WITH DIHYDROPYRAN-PHENETHYL-PROPYL-CARBOXAMIDE
Release Data : 1999-03-02
Compound :
mol_id molecule chains synonym
1 NEURAMINIDASE A,B SIALIDASE
ec: 3.2.1.18
fragment: RESIDUES 76-465
Source :
mol_id organism_scientific
1 Influenza B virus (STRAIN B/BEIJING/1/87)  (taxid:11525)
strain: B/Beijing/1/87
Authors : Cleasby, A., Singh, O., Skarzynski, T., Wonacott, A.J.
Keywords : HYDROLASE, GLYCOSIDASE, GLYCOSYLATED PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.

Taylor, N.R.,Cleasby, A.,Singh, O.  et al.
(1998)  J.Med.Chem.  41 : 798 - 807

PubMed: 9526556
DOI: 10.1021/jm9703754

The 2.2 A Resolution Crystal Structure of Influenza B Neuraminidase and its Complex with Sialic Acid

Burmeister, W.P.,Ruigrok, R.W.,Cusack, S.
(1992)  Embo J.  11 : 49

Sequence and Crystallization of Influenza Virus B/Beijing/1/87 Neuraminidase

Burmeister, W.P.,Daniels, R.S.,Dayan, S.  et al.
(1991)  Virology  180 : 266

Reaction

Chain : A, B
UniProt : P27907 (NRAM_INBBE)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha- (2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. 3.2.1.18 HAMAP-Rule:MF_04071
-
Cofactor: Evidence: Note:
Ca(2+) ECO:0000255 | HAMAP-Rule:MF_04071
ECO:0000269 | PubMed:1740114
Binds 1 Ca(2+) ion per subunit.