Brand  (β version)

PDB ID: 1A1B

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
PTR O-phosphotyrosine
Glycosylation
Code Name Emphasize
Modification
Code Name Show
ACE Acetyl group
DIP Dipentylamine

Structure summary

Code : 1A1B   PDBj   RCSB PDB   PDBe
Header : COMPLEX (TRANSFERASE/PEPTIDE)
Title : C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Release Data : 1998-04-08
Compound :
mol_id molecule chains
1 C-SRC TYROSINE KINASE A,B
ec: 2.7.1.112
fragment: SH2 DOMAIN
mol_id molecule chains
2 ACE-PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE) C,D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:511693)
cellular_location: CYTOPLASM
gene: SRC
expression_system_strain: BL21
expression_system_cellular_location: CYTOPLASM
expression_system_plasmid: PET11B
expression_system_gene: SRC
mol_id organism_scientific
2
Authors : Shewchuk, L., Jordan, S.
Keywords : COMPLEX (TRANSFERASE-PEPTIDE), COMPLEX (TRANSFERASE-PEPTIDE) complex
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.

Charifson, P.S.,Shewchuk, L.M.,Rocque, W.  et al.
(1997)  Biochemistry  36 : 6283 - 6293

PubMed: 9174343
DOI: 10.1021/bi970019n

Reaction

Chain : A, B
UniProt : P12931 (SRC_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:14632929, PubMed:19307596, PubMed:21036157, PubMed:25501895, PubMed:34234773, PubMed:35927303, PubMed:7929427, PubMed:8759729, PubMed:9571170
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[Isoform 1]
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 		2.7.10.2 UniProtKB:Q9WUD9
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[Isoform 2]
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 		2.7.10.2 UniProtKB:Q9WUD9
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[Isoform 3]
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 		2.7.10.2 UniProtKB:Q9WUD9
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