Brand  (β version)

PDB ID: 1A0H

Hetero Atom Contents

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0G6 D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide PoSSuM
Modified Residues
Code Name Link
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose PoSSuM

Structure summary

Code : 1A0H   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : THE X-RAY CRYSTAL STRUCTURE OF PPACK-MEIZOTHROMBIN DESF1: KRINGLE/THROMBIN AND CARBOHYDRATE/KRINGLE/THROMBIN INTERACTIONS AND LOCATION OF THE LINKER CHAIN
Release Data : 1998-06-17
Compound :
mol_id molecule chains synonym
1 MEIZOTHROMBIN A,D DESF1
ec: 3.4.21.5
fragment: F2/THROMBIN DOMAIN
mol_id molecule chains synonym
2 MEIZOTHROMBIN B,E DESF1
ec: 3.4.21.5
fragment: F2/THROMBIN DOMAIN
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
organ: BLOOD
tissue: BLOOD PLASMA
mol_id organism_scientific organism_common
2 Bos taurus  (taxid:9913) Cattle
organ: BLOOD
tissue: BLOOD PLASMA
Authors : Martin, P.D., Malkowski, M.G., Box, J., Esmon, C.T., Edwards, B.F.P.
Keywords : SERINE PROTEASE, COAGULATION, THROMBIN, PROTHROMBIN, MEIZOTHROMBIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 3.2 Å )
Citation :

New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK.

Martin, P.D.,Malkowski, M.G.,Box, J.  et al.
(1997)  Structure  5 : 1681 - 1693

PubMed: 9438869
DOI: 10.1016/S0969-2126(97)00314-6

Reaction

Chain : B, E
UniProt : P00735 (THRB_BOVIN)
Reaction : Reaction=Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.; EC=3.4.21.5;