Brand  (β version)

PDB ID: 117E

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Ligands
Code Name Style Show Link
MN Manganese (II) ion PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 117E   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : THE R78K AND D117E ACTIVE SITE VARIANTS OF SACCHAROMYCES CEREVISIAE SOLUBLE INORGANIC PYROPHOSPHATASE: STRUCTURAL STUDIES AND MECHANISTIC IMPLICATIONS
Release Data : 1998-12-23
Compound :
mol_id molecule chains synonym
1 PROTEIN (INORGANIC PYROPHOSPHATASE) A,B PPASE
ec: 3.6.1.1
mutation: D117E
other_details: PRODUCT COMPLEX
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast Escherichia coli  (taxid:562)
cellular_location: CYTOPLASM
gene: PPA1
expression_system_strain: HB101
Authors : Tuominen, V., Heikinheimo, P., Kajander, T., Torkkel, T., Hyytia, T., Kapyla, J., Lahti, R., Cooperman, B.S., Goldman, A.
Keywords : ENZYME MECHANISM, IORGANIC PYROPHOSPHATASE, MUTAN STRUCTURES, 2-METAL ION MECHANISM, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications.

Tuominen, V.,Heikinheimo, P.,Kajander, T.  et al.
(1998)  J.Mol.Biol.  284 : 1565 - 1580

PubMed: 9878371
DOI: 10.1006/jmbi.1998.2266

Reaction

Chain : A, B
UniProt : P00817 (IPYR_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
diphosphate + H2O = H(+) + 2 phosphate 3.6.1.1 -
-