Brand  (β version)

PDB ID: 6QXS

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
UFP 5-fluoro-2'-deoxyuridine-5'-monophosphate PoSSuM
SO4 Sulfate ion PoSSuM
FFO N-[4-({[(6s)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid PoSSuM
Non-standard Residues
Code Name Show
CME S,S-(2-hydroxyethyl)thiocysteine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6QXS   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of Enteroccocus faecalis thymidylate synthase (EfTS) in complex with FdUMP
Release Data : 2019-04-10
Compound :
mol_id molecule chains synonym
1 Thymidylate synthase A TSase
ec: 2.1.1.45
mol_id molecule chains synonym
2 Thymidylate synthase B,C,D TSase
ec: 2.1.1.45
Source :
mol_id organism_scientific expression_system
1 Enterococcus faecalis (strain ATCC 700802 / V583)  (taxid:226185) Escherichia coli  (taxid:562)
strain: ATCC 700802 / V583
gene: thyA, EF_1576
mol_id organism_scientific expression_system
2 Enterococcus faecalis  (taxid:1351) Escherichia coli  (taxid:562)
strain: ATCC 700802 / V583
gene: thyA, EF_1576
Authors : Pozzi, C., Mangani, M.
Keywords : Enteroccocus faecalis thymidylate synthase, EfTS, folate pathway, inhibitor, FdUMP, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.88 Å )
Citation :

Structural Comparison ofEnterococcus faecalisand Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities.

Pozzi, C.,Ferrari, S.,Luciani, R.  et al.
(2019)  Molecules  24

PubMed: 30935102
DOI: 10.3390/molecules24071257

Reaction

Chain : B, C, D
UniProt : Q834R3 (TYSY_ENTFA)
Reaction: EC: Evidence:
Physiological Direction:
dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8- dihydrofolate + dTMP 2.1.1.45 HAMAP-Rule:MF_00008
-