PDB ID: 6GL9
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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F3W | (~{E})-3-[3-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)phenyl]prop-2-enenitrile | PoSSuM | |||
PHU | 1-phenylurea | PoSSuM | |||
GOL | Glycerol | PoSSuM | |||
EDO | 1,2-ethanediol | PoSSuM |
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Download interaction data: 6GL9
Structure summary
Code : | 6GL9 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | Crystal structure of JAK3 in complex with Compound 10 (FM475) | ||||||||||||
Release Data : | 2018-06-27 | ||||||||||||
Compound : |
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Source : |
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Authors : | Chaikuad, A., Forster, M., von Delft, F., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Laufer, S.A., Knapp, S., Structural Genomics Consortium (SGC) | ||||||||||||
Keywords : | KINASE, JAK3, COVALENT INHIBITOR, REVERSIBLE COVALENT INHIBITOR, INDUCED POCKET, ARGININE POCKET, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.70 Å ) | ||||||||||||
Citation : |
Development, Optimization, and Structure-Activity Relationships of Covalent-Reversible JAK3 Inhibitors Based on a Tricyclic Imidazo[5,4- d]pyrrolo[2,3- b]pyridine Scaffold.
Forster, M.,Chaikuad, A.,Dimitrov, T.
et al.
PubMed: 29852068 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | P52333 (JAK3_HUMAN) | ||||||||
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