ID	6GL9A	STANDARD;	PRT;	294	AA.
DT	CONVERTED FROM PDB (SEQRES) 6GL9
DE	Tyrosine-protein kinase JAK3
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.700
CC	R-Factor	0.209
FT	#SUB	50	 859 	HIS	A	275	1084 	ASP	B	Protein	S	2
FT	#SUB	175	 984 	ARG	A	126	 935 	LYS	B	Protein	S	1
FT	#SUB	175	 984 	ARG	A	284	1093 	PRO	B	Protein	S	8
FT	#SUB	175	 984 	ARG	A	287	1096 	ASP	B	Protein	S	4
FT	#SUB	176	 985 	GLU	A	129	 938 	GLU	B	Protein	S	1
FT	#SUB	176	 985 	GLU	A	130	 939 	TYR	B	Protein	S	1
FT	#SUB	176	 985 	GLU	A	133	 942 	SER	B	Protein	S	2
FT	#SUB	176	 985 	GLU	A	280	1089 	SER	B	Protein	B	2
FT	#SUB	177	 986 	PRO	A	280	1089 	SER	B	Protein	B	2
FT	#SUB	179	 988 	GLN	A	135	 944 	ARG	B	Protein	S	3
FT	#SUB	179	 988 	GLN	A	170	 979 	ASP	B	Protein	S	1
FT	#SUB	179	 988 	GLN	A	197	1006 	ARG	B	Protein	S	7
FT	#SUB	234	1043 	ASP	A	57	 866 	ARG	B	Protein	S	6
FT	#SUB	234	1043 	ASP	A	61	 870 	ARG	B	Protein	S	13
FT	#SUB	234	1043 	ASP	A	64	 873 	GLN	B	Protein	B	3
FT	#SUB	234	1043 	ASP	A	65	 874 	ILE	B	Protein	B	2
FT	#SUB	234	1043 	ASP	A	164	 973 	LEU	B	Protein	B	2
FT	#SUB	235	1044 	VAL	A	64	 873 	GLN	B	Protein	S	1
FT	#SUB	235	1044 	VAL	A	164	 973 	LEU	B	Protein	B	2
FT	#SUB	236	1045 	PRO	A	68	 877 	ALA	B	Protein	S	2
FT	#SUB	236	1045 	PRO	A	134	 943 	ARG	B	Protein	S	2
FT	#SUB	236	1045 	PRO	A	164	 973 	LEU	B	Protein	B	2
FT	#SUB	237	1046 	ALA	A	167	 976 	LEU	B	Protein	S	1
FT	#SUB	238	1047 	LEU	A	133	 942 	SER	B	Protein	S	1
FT	#SUB	238	1047 	LEU	A	134	 943 	ARG	B	Protein	S	2
FT	#SUB	239	1048 	SER	A	68	 877 	ALA	B	Protein	S	4
FT	#SUB	239	1048 	SER	A	134	 943 	ARG	B	Protein	S	2
FT	#HET	14	 823 	LYS	A	4	1204 	EDO	A	S	2
FT	#HET	18	 827 	GLN	A	5	1205 	EDO	A	S	4
FT	#HET	19	 828 	LEU	A	1	1201 	F3W	A	A	9
FT	#HET	20	 829 	GLY	A	1	1201 	F3W	A	B	1
FT	#HET	21	 830 	LYS	A	5	1205 	EDO	A	S	4
FT	#HET	22	 831 	GLY	A	6	1206 	EDO	A	B	3
FT	#HET	25	 834 	GLY	A	6	1206 	EDO	A	B	4
FT	#HET	26	 835 	SER	A	6	1206 	EDO	A	B	2
FT	#HET	27	 836 	VAL	A	1	1201 	F3W	A	S	3
FT	#HET	27	 836 	VAL	A	6	1206 	EDO	A	S	2
FT	#HET	31	 840 	ARG	A	4	1204 	EDO	A	S	7
FT	#HET	38	 847 	ASN	A	4	1204 	EDO	A	S	3
FT	#HET	44	 853 	ALA	A	1	1201 	F3W	A	S	2
FT	#HET	46	 855 	LYS	A	6	1206 	EDO	A	S	2
FT	#HET	54	 863 	ASP	A	7	1207 	EDO	A	A	10
FT	#HET	58	 867 	ASP	A	7	1207 	EDO	A	S	5
FT	#HET	66	 875 	LEU	A	8	1208 	EDO	A	B	1
FT	#HET	67	 876 	LYS	A	8	1208 	EDO	A	B	4
FT	#HET	69	 878 	LEU	A	8	1208 	EDO	A	B	3
FT	#HET	70	 879 	HIS	A	8	1208 	EDO	A	S	4
FT	#HET	75	 884 	VAL	A	1	1201 	F3W	A	S	2
FT	#HET	76	 885 	LYS	A	8	1208 	EDO	A	S	3
FT	#HET	77	 886 	TYR	A	8	1208 	EDO	A	A	8
FT	#HET	94	 903 	GLU	A	1	1201 	F3W	A	B	4
FT	#HET	95	 904 	TYR	A	1	1201 	F3W	A	A	5
FT	#HET	96	 905 	LEU	A	1	1201 	F3W	A	B	5
FT	#HET	100	 909 	CYS	A	1	1201 	F3W	A	S	8
FT	#HET	102	 911 	ARG	A	1	1201 	F3W	A	S	4
FT	#HET	102	 911 	ARG	A	9	1209 	EDO	A	S	9
FT	#HET	103	 912 	ASP	A	1	1201 	F3W	A	S	6
FT	#HET	106	 915 	GLN	A	9	1209 	EDO	A	S	1
FT	#HET	108	 917 	HIS	A	10	1210 	EDO	A	S	2
FT	#HET	111	 920 	ARG	A	10	1210 	EDO	A	S	3
FT	#HET	137	 946 	VAL	A	3	1203 	GOL	A	S	1
FT	#HET	139	 948 	ARG	A	3	1203 	GOL	A	A	4
FT	#HET	144	 953 	ARG	A	1	1201 	F3W	A	A	11
FT	#HET	145	 954 	ASN	A	1	1201 	F3W	A	S	1
FT	#HET	147	 956 	LEU	A	1	1201 	F3W	A	S	13
FT	#HET	158	 967 	ASP	A	1	1201 	F3W	A	S	1
FT	#HET	183	 992 	PHE	A	2	1202 	PHU	A	S	1
FT	#HET	184	 993 	TRP	A	3	1203 	GOL	A	B	1
FT	#HET	185	 994 	TYR	A	3	1203 	GOL	A	A	16
FT	#HET	186	 995 	ALA	A	3	1203 	GOL	A	A	4
FT	#HET	189	 998 	SER	A	3	1203 	GOL	A	S	3
FT	#HET	195	1004 	PHE	A	3	1203 	GOL	A	S	5
FT	#HET	196	1005 	SER	A	3	1203 	GOL	A	B	1
FT	#HET	199	1008 	SER	A	3	1203 	GOL	A	A	15
FT	#HET	200	1009 	ASP	A	3	1203 	GOL	A	A	8
FT	#HET	202	1011 	TRP	A	2	1202 	PHU	A	S	3
FT	#HET	203	1012 	SER	A	3	1203 	GOL	A	S	5
FT	#HET	210	1019 	GLU	A	9	1209 	EDO	A	S	4
FT	#HET	215	1024 	CYS	A	9	1209 	EDO	A	A	7
FT	#HET	220	1029 	SER	A	9	1209 	EDO	A	S	1
FT	#HET	221	1030 	PRO	A	2	1202 	PHU	A	B	1
FT	#HET	225	1034 	PHE	A	2	1202 	PHU	A	A	2
FT	#HET	228	1037 	MET	A	2	1202 	PHU	A	S	2
FT	#HET	245	1054 	LEU	A	2	1202 	PHU	A	S	3
FT	#HET	250	1059 	ARG	A	2	1202 	PHU	A	A	4
FT	#HET	251	1060 	LEU	A	2	1202 	PHU	A	A	19
FT	#HET	269	1078 	TRP	A	2	1202 	PHU	A	S	8
FT	DISORDER	1	2
CC	SEQUENCE	292 AA (ATOM);
CC	QDPTIFEERH LKYISQLGKG NFGSVELCRY DPLGDNTGAL VAVKQLQHSG PDQQRDFQRE
CC	IQILKALHSD FIVKYRGVSY GPGRQSLRLV MEYLPSGCLR DFLQRHRARL DASRLLLYSS
CC	QICKGMEYLG SRRCVHRALA ARNILVESEA HVKIADFGLA KLLPLDKDYY VVREPGQSPI
CC	FWYAPESLSD NIFSRQSDVW SFGVVLYELF TYCDKSCSPS AEFLRMMGSE RDVPALSRLL
CC	ELLEEGQRLP APPACPAEVH ELMKLCWAPS PQDRPSFSAL GPQLDMLWSG SR
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES SMQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH
CC	ATOM   --QDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH
CC	         ************************************************
CC	SEQRES SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGC
CC	ATOM   SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGC
CC	       **************************************************
CC	SEQRES LRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVES
CC	ATOM   LRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVES
CC	       **************************************************
CC	SEQRES EAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSD
CC	ATOM   EAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSD
CC	       **************************************************
CC	SEQRES VWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQR
CC	ATOM   VWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQR
CC	       **************************************************
CC	SEQRES LPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR
CC	ATOM   LPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR
CC	       ********************************************
SQ	SEQUENCE	294 AA;      MW;         CN;
	SMQDPTIFEE RHLKYISQLG KGNFGSVELC RYDPLGDNTG ALVAVKQLQH SGPDQQRDFQ
	REIQILKALH SDFIVKYRGV SYGPGRQSLR LVMEYLPSGC LRDFLQRHRA RLDASRLLLY
	SSQICKGMEY LGSRRCVHRA LAARNILVES EAHVKIADFG LAKLLPLDKD YYVVREPGQS
	PIFWYAPESL SDNIFSRQSD VWSFGVVLYE LFTYCDKSCS PSAEFLRMMG SERDVPALSR
	LLELLEEGQR LPAPPACPAE VHELMKLCWA PSPQDRPSFS ALGPQLDMLW SGSR
//
ID	6GL9B	STANDARD;	PRT;	294	AA.
DT	CONVERTED FROM PDB (SEQRES) 6GL9
DE	Tyrosine-protein kinase JAK3
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.700
CC	R-Factor	0.209
FT	#SUB	57	 866 	ARG	B	234	1043 	ASP	A	Protein	S	6
FT	#SUB	61	 870 	ARG	B	234	1043 	ASP	A	Protein	A	13
FT	#SUB	64	 873 	GLN	B	234	1043 	ASP	A	Protein	A	3
FT	#SUB	64	 873 	GLN	B	235	1044 	VAL	A	Protein	S	1
FT	#SUB	65	 874 	ILE	B	234	1043 	ASP	A	Protein	A	2
FT	#SUB	68	 877 	ALA	B	236	1045 	PRO	A	Protein	S	2
FT	#SUB	68	 877 	ALA	B	239	1048 	SER	A	Protein	A	4
FT	#SUB	126	 935 	LYS	B	175	 984 	ARG	A	Protein	S	1
FT	#SUB	129	 938 	GLU	B	176	 985 	GLU	A	Protein	S	1
FT	#SUB	130	 939 	TYR	B	176	 985 	GLU	A	Protein	B	1
FT	#SUB	133	 942 	SER	B	176	 985 	GLU	A	Protein	S	2
FT	#SUB	133	 942 	SER	B	238	1047 	LEU	A	Protein	B	1
FT	#SUB	134	 943 	ARG	B	236	1045 	PRO	A	Protein	S	2
FT	#SUB	134	 943 	ARG	B	238	1047 	LEU	A	Protein	S	2
FT	#SUB	134	 943 	ARG	B	239	1048 	SER	A	Protein	S	2
FT	#SUB	135	 944 	ARG	B	179	 988 	GLN	A	Protein	S	3
FT	#SUB	164	 973 	LEU	B	234	1043 	ASP	A	Protein	S	2
FT	#SUB	164	 973 	LEU	B	235	1044 	VAL	A	Protein	S	2
FT	#SUB	164	 973 	LEU	B	236	1045 	PRO	A	Protein	S	2
FT	#SUB	167	 976 	LEU	B	237	1046 	ALA	A	Protein	S	1
FT	#SUB	170	 979 	ASP	B	179	 988 	GLN	A	Protein	S	1
FT	#SUB	197	1006 	ARG	B	179	 988 	GLN	A	Protein	S	7
FT	#SUB	275	1084 	ASP	B	50	 859 	HIS	A	Protein	S	2
FT	#SUB	280	1089 	SER	B	176	 985 	GLU	A	Protein	S	2
FT	#SUB	280	1089 	SER	B	177	 986 	PRO	A	Protein	S	2
FT	#SUB	284	1093 	PRO	B	175	 984 	ARG	A	Protein	A	8
FT	#SUB	287	1096 	ASP	B	175	 984 	ARG	A	Protein	S	4
FT	#HET	14	 823 	LYS	B	14	1204 	EDO	B	S	1
FT	#HET	19	 828 	LEU	B	11	1201 	F3W	B	A	10
FT	#HET	20	 829 	GLY	B	11	1201 	F3W	B	B	1
FT	#HET	22	 831 	GLY	B	15	1205 	EDO	B	B	1
FT	#HET	25	 834 	GLY	B	15	1205 	EDO	B	B	2
FT	#HET	26	 835 	SER	B	15	1205 	EDO	B	B	2
FT	#HET	27	 836 	VAL	B	11	1201 	F3W	B	S	3
FT	#HET	27	 836 	VAL	B	15	1205 	EDO	B	S	1
FT	#HET	31	 840 	ARG	B	14	1204 	EDO	B	S	6
FT	#HET	37	 846 	ASP	B	16	1206 	EDO	B	B	2
FT	#HET	38	 847 	ASN	B	14	1204 	EDO	B	S	4
FT	#HET	38	 847 	ASN	B	16	1206 	EDO	B	A	2
FT	#HET	39	 848 	THR	B	16	1206 	EDO	B	S	1
FT	#HET	44	 853 	ALA	B	11	1201 	F3W	B	S	3
FT	#HET	46	 855 	LYS	B	15	1205 	EDO	B	S	2
FT	#HET	66	 875 	LEU	B	17	1207 	EDO	B	B	1
FT	#HET	67	 876 	LYS	B	17	1207 	EDO	B	B	1
FT	#HET	69	 878 	LEU	B	17	1207 	EDO	B	B	2
FT	#HET	70	 879 	HIS	B	17	1207 	EDO	B	S	2
FT	#HET	75	 884 	VAL	B	11	1201 	F3W	B	S	2
FT	#HET	76	 885 	LYS	B	17	1207 	EDO	B	S	2
FT	#HET	77	 886 	TYR	B	17	1207 	EDO	B	A	7
FT	#HET	94	 903 	GLU	B	11	1201 	F3W	B	B	4
FT	#HET	95	 904 	TYR	B	11	1201 	F3W	B	A	5
FT	#HET	96	 905 	LEU	B	11	1201 	F3W	B	B	5
FT	#HET	100	 909 	CYS	B	11	1201 	F3W	B	S	8
FT	#HET	102	 911 	ARG	B	11	1201 	F3W	B	S	6
FT	#HET	102	 911 	ARG	B	18	1208 	EDO	B	S	6
FT	#HET	103	 912 	ASP	B	11	1201 	F3W	B	S	5
FT	#HET	137	 946 	VAL	B	13	1203 	GOL	B	S	1
FT	#HET	139	 948 	ARG	B	13	1203 	GOL	B	A	5
FT	#HET	144	 953 	ARG	B	11	1201 	F3W	B	A	11
FT	#HET	145	 954 	ASN	B	11	1201 	F3W	B	S	1
FT	#HET	147	 956 	LEU	B	11	1201 	F3W	B	S	11
FT	#HET	158	 967 	ASP	B	11	1201 	F3W	B	S	1
FT	#HET	183	 992 	PHE	B	12	1202 	PHU	B	S	1
FT	#HET	184	 993 	TRP	B	13	1203 	GOL	B	B	1
FT	#HET	185	 994 	TYR	B	13	1203 	GOL	B	A	13
FT	#HET	186	 995 	ALA	B	13	1203 	GOL	B	A	4
FT	#HET	189	 998 	SER	B	13	1203 	GOL	B	S	3
FT	#HET	195	1004 	PHE	B	13	1203 	GOL	B	S	5
FT	#HET	196	1005 	SER	B	13	1203 	GOL	B	B	1
FT	#HET	199	1008 	SER	B	13	1203 	GOL	B	A	15
FT	#HET	200	1009 	ASP	B	13	1203 	GOL	B	A	7
FT	#HET	202	1011 	TRP	B	12	1202 	PHU	B	S	3
FT	#HET	203	1012 	SER	B	13	1203 	GOL	B	S	6
FT	#HET	210	1019 	GLU	B	18	1208 	EDO	B	S	5
FT	#HET	215	1024 	CYS	B	18	1208 	EDO	B	B	4
FT	#HET	216	1025 	ASP	B	18	1208 	EDO	B	B	1
FT	#HET	220	1029 	SER	B	18	1208 	EDO	B	A	3
FT	#HET	220	1029 	SER	B	19	1209 	EDO	B	S	1
FT	#HET	221	1030 	PRO	B	12	1202 	PHU	B	B	1
FT	#HET	222	1031 	SER	B	19	1209 	EDO	B	A	5
FT	#HET	223	1032 	ALA	B	19	1209 	EDO	B	A	3
FT	#HET	225	1034 	PHE	B	12	1202 	PHU	B	A	2
FT	#HET	226	1035 	LEU	B	19	1209 	EDO	B	S	2
FT	#HET	228	1037 	MET	B	12	1202 	PHU	B	S	2
FT	#HET	241	1050 	LEU	B	12	1202 	PHU	B	S	2
FT	#HET	245	1054 	LEU	B	12	1202 	PHU	B	S	2
FT	#HET	250	1059 	ARG	B	12	1202 	PHU	B	A	4
FT	#HET	251	1060 	LEU	B	12	1202 	PHU	B	A	20
FT	#HET	269	1078 	TRP	B	12	1202 	PHU	B	S	9
FT	DISORDER	1	3
CC	SEQUENCE	291 AA (ATOM);
CC	DPTIFEERHL KYISQLGKGN FGSVELCRYD PLGDNTGALV AVKQLQHSGP DQQRDFQREI
CC	QILKALHSDF IVKYRGVSYG PGRQSLRLVM EYLPSGCLRD FLQRHRARLD ASRLLLYSSQ
CC	ICKGMEYLGS RRCVHRALAA RNILVESEAH VKIADFGLAK LLPLDKDYYV VREPGQSPIF
CC	WYAPESLSDN IFSRQSDVWS FGVVLYELFT YCDKSCSPSA EFLRMMGSER DVPALSRLLE
CC	LLEEGQRLPA PPACPAEVHE LMKLCWAPSP QDRPSFSALG PQLDMLWSGS R
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES SMQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH
CC	ATOM   ---DPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH
CC	          ***********************************************
CC	SEQRES SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGC
CC	ATOM   SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGC
CC	       **************************************************
CC	SEQRES LRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVES
CC	ATOM   LRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVES
CC	       **************************************************
CC	SEQRES EAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSD
CC	ATOM   EAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSD
CC	       **************************************************
CC	SEQRES VWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQR
CC	ATOM   VWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQR
CC	       **************************************************
CC	SEQRES LPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR
CC	ATOM   LPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR
CC	       ********************************************
SQ	SEQUENCE	294 AA;      MW;         CN;
	SMQDPTIFEE RHLKYISQLG KGNFGSVELC RYDPLGDNTG ALVAVKQLQH SGPDQQRDFQ
	REIQILKALH SDFIVKYRGV SYGPGRQSLR LVMEYLPSGC LRDFLQRHRA RLDASRLLLY
	SSQICKGMEY LGSRRCVHRA LAARNILVES EAHVKIADFG LAKLLPLDKD YYVVREPGQS
	PIFWYAPESL SDNIFSRQSD VWSFGVVLYE LFTYCDKSCS PSAEFLRMMG SERDVPALSR
	LLELLEEGQR LPAPPACPAE VHELMKLCWA PSPQDRPSFS ALGPQLDMLW SGSR
//