Brand  (β version)

PDB ID: 6U26

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Structure summary

Code : 6U26   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE Inhibitor
Title : PCSK9 in complex with compound 16
Release Data : 2019-11-06
Compound :
mol_id molecule chains synonym
1 Proprotein convertase subtilisin/kexin type 9 A,B Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
ec: 3.4.21.-
mutation: V474I, G670E
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: PCSK9, NARC1, PSEC0052
Authors : Orth, P.
Keywords : CHOLESTEROL CLEARANCE, PCSK9, LDLR, Autocatalytic cleavage, Cholesterol metabolism, Disulfide bond, Glycoprotein, Hydrolase, Lipid metabolism, Phosphoprotein, Protease, Secreted, Serine protease, inhibitor, HYDROLASE-HYDROLASE Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.5300 Å )
Citation :

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.

Petrilli, W.L.,Adam, G.C.,Erdmann, R.S.  et al.
(2020)  Cell Chem Biol  27 : 32 - 40.e3

PubMed: 31653597
DOI: 10.1016/j.chembiol.2019.10.002

Reaction

Chain : A, B
UniProt : Q8NBP7 (PCSK9_HUMAN)
Reaction : -