ID 6U26A STANDARD; PRT; 707 AA. DT CONVERTED FROM PDB (SEQRES) 6U26 DE Proprotein convertase subtilisin/kexin type 9 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.530 CC R-Factor 0.189 FT #SUB 33 63 THR A 265 295 ARG B Protein S 1 FT #SUB 35 65 HIS A 265 295 ARG B Protein S 3 FT #SUB 39 69 LYS A 294 324 LEU B Protein S 1 FT #SUB 39 69 LYS A 295 325 TYR B Protein S 5 FT #SUB 42 72 TRP A 261 291 GLY B Protein S 2 FT #SUB 42 72 TRP A 262 292 GLY B Protein S 2 FT #SUB 42 72 TRP A 288 318 PHE B Protein S 4 FT #SUB 44 74 LEU A 230 260 THR B Protein S 1 FT #SUB 49 79 VAL A 266 296 VAL B Protein S 1 FT #SUB 51 81 VAL A 266 296 VAL B Protein S 1 FT #SUB 54 84 GLU A 273 303 ARG B Protein A 6 FT #SUB 83 113 HIS A 236 266 ILE B Protein S 6 FT #SUB 83 113 HIS A 239 269 GLU B Protein S 4 FT #SUB 85 115 PHE A 235 265 LEU B Protein S 1 FT #SUB 85 115 PHE A 236 266 ILE B Protein S 2 FT #SUB 85 115 PHE A 239 269 GLU B Protein A 5 FT #SUB 86 116 HIS A 239 269 GLU B Protein B 7 FT #SUB 86 116 HIS A 243 273 LYS B Protein A 3 FT #SUB 87 117 GLY A 242 272 ARG B Protein B 1 FT #SUB 88 118 LEU A 238 268 LEU B Protein S 3 FT #SUB 88 118 LEU A 239 269 GLU B Protein S 2 FT #SUB 88 118 LEU A 242 272 ARG B Protein S 2 FT #SUB 88 118 LEU A 273 303 ARG B Protein B 7 FT #SUB 88 118 LEU A 274 304 LEU B Protein S 3 FT #SUB 89 119 LEU A 266 296 VAL B Protein S 2 FT #SUB 89 119 LEU A 269 299 ALA B Protein S 1 FT #SUB 89 119 LEU A 270 300 ALA B Protein S 1 FT #SUB 89 119 LEU A 273 303 ARG B Protein A 6 FT #SUB 90 120 PRO A 273 303 ARG B Protein S 1 FT #SUB 93 123 LEU A 232 262 SER B Protein S 3 FT #SUB 112 142 TYR A 265 295 ARG B Protein S 18 FT #SUB 112 142 TYR A 266 296 VAL B Protein S 1 FT #SUB 112 142 TYR A 269 299 ALA B Protein S 1 FT #SUB 114 144 GLU A 264 294 SER B Protein S 6 FT #SUB 114 144 GLU A 265 295 ARG B Protein S 4 FT #SUB 114 144 GLU A 266 296 VAL B Protein S 7 FT #SUB 116 146 ASP A 230 260 THR B Protein S 2 FT #SUB 116 146 ASP A 231 261 VAL B Protein S 4 FT #SUB 116 146 ASP A 232 262 SER B Protein S 10 FT #SUB 117 147 SER A 230 260 THR B Protein B 3 FT #SUB 117 147 SER A 231 261 VAL B Protein A 5 FT #SUB 118 148 SER A 229 259 GLY B Protein A 3 FT #SUB 118 148 SER A 261 291 GLY B Protein B 1 FT #SUB 119 149 VAL A 228 258 LYS B Protein B 3 FT #SUB 119 149 VAL A 229 259 GLY B Protein A 10 FT #SUB 119 149 VAL A 230 260 THR B Protein S 2 FT #SUB 119 149 VAL A 231 261 VAL B Protein S 1 FT #SUB 119 149 VAL A 234 264 THR B Protein S 1 FT #SUB 119 149 VAL A 260 290 ALA B Protein A 3 FT #SUB 120 150 PHE A 227 257 GLY B Protein B 2 FT #SUB 120 150 PHE A 228 258 LYS B Protein S 2 FT #SUB 120 150 PHE A 259 289 LEU B Protein B 3 FT #SUB 120 150 PHE A 260 290 ALA B Protein A 7 FT #SUB 121 151 ALA A 196 226 HIS B Protein A 6 FT #SUB 121 151 ALA A 223 253 LEU B Protein A 3 FT #SUB 121 151 ALA A 227 257 GLY B Protein A 3 FT #SUB 121 151 ALA A 258 288 PRO B Protein B 2 FT #SUB 122 152 GLN A 196 226 HIS B Protein B 3 FT #SUB 122 152 GLN A 258 288 PRO B Protein A 2 FT #SUB 122 152 GLN A 259 289 LEU B Protein S 2 FT #SUB 122 152 GLN A 260 290 ALA B Protein S 3 FT #SUB 122 152 GLN A 284 314 ALA B Protein S 1 FT #SUB 122 152 GLN A 286 316 GLY B Protein S 3 FT #SUB 122 152 GLN A 287 317 ASN B Protein A 13 FT #SUB 122 152 GLN A 288 318 PHE B Protein S 3 FT #SUB 122 152 GLN A 354 384 GLY B Protein B 2 FT #SUB 122 152 GLN A 355 385 THR B Protein A 3 FT #SUB 122 152 GLN A 356 386 SER B Protein A 11 FT DISORDER 1 30 FT DISORDER 123 707 CC SEQUENCE 92 AA (ATOM); CC TATFHRCAKD PWRLPGTYVV VLKEETHLSQ SERTARRLQA QAARRGYLTK ILHVFHGLLP CC GFLVKMSGDL LELALKLPHV DYIEEDSSVF AQ CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES QEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVV CC ATOM ------------------------------TATFHRCAKDPWRLPGTYVV CC ******************** CC SEQRES VLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDL CC ATOM VLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDL CC ************************************************** CC SEQRES LELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLV CC ATOM LELALKLPHVDYIEEDSSVFAQ---------------------------- CC ********************** CC SEQRES EVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHL CC ATOM -------------------------------------------------- CC CC SEQRES AGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPV CC ATOM -------------------------------------------------- CC CC SEQRES GPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASA CC ATOM -------------------------------------------------- CC CC SEQRES PEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFV CC ATOM -------------------------------------------------- CC CC SEQRES SQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFP CC ATOM -------------------------------------------------- CC CC SEQRES EDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAIARCAPD CC ATOM -------------------------------------------------- CC CC SEQRES EELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLP CC ATOM -------------------------------------------------- CC CC SEQRES QANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLR CC ATOM -------------------------------------------------- CC CC SEQRES PRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTVACEEGW CC ATOM -------------------------------------------------- CC CC SEQRES TLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEEAVTAVAICCR CC ATOM -------------------------------------------------- CC CC SEQRES SRHLAQASQELQKGNSADIQHSGGRSSLEGPRFEGKPIPNPLLGLDSTRT CC ATOM -------------------------------------------------- CC CC SEQRES GHHHHHH CC ATOM ------- CC SQ SEQUENCE 707 AA; MW; CN; QEDEDGDYEE LVLALRSEED GLAEAPEHGT TATFHRCAKD PWRLPGTYVV VLKEETHLSQ SERTARRLQA QAARRGYLTK ILHVFHGLLP GFLVKMSGDL LELALKLPHV DYIEEDSSVF AQSIPWNLER ITPPRYRADE YQPPDGGSLV EVYLLDTSIQ SDHREIEGRV MVTDFENVPE EDGTRFHRQA SKCDSHGTHL AGVVSGRDAG VAKGASMRSL RVLNCQGKGT VSGTLIGLEF IRKSQLVQPV GPLVVLLPLA GGYSRVLNAA CQRLARAGVV LVTAAGNFRD DACLYSPASA PEVITVGATN AQDQPVTLGT LGTNFGRCVD LFAPGEDIIG ASSDCSTCFV SQSGTSQAAA HVAGIAAMML SAEPELTLAE LRQRLIHFSA KDVINEAWFP EDQRVLTPNL VAALPPSTHG AGWQLFCRTV WSAHSGPTRM ATAIARCAPD EELLSCSSFS RSGKRRGERM EAQGGKLVCR AHNAFGGEGV YAIARCCLLP QANCSVHTAP PAEASMGTRV HCHQQGHVLT GCSSHWEVED LGTHKPPVLR PRGQPNQCVG HREASIHASC CHAPGLECKV KEHGIPAPQE QVTVACEEGW TLTGCSALPG TSHVLGAYAV DNTCVVRSRD VSTTGSTSEE AVTAVAICCR SRHLAQASQE LQKGNSADIQ HSGGRSSLEG PRFEGKPIPN PLLGLDSTRT GHHHHHH // ID 6U26B STANDARD; PRT; 707 AA. DT CONVERTED FROM PDB (SEQRES) 6U26 DE Proprotein convertase subtilisin/kexin type 9 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.530 CC R-Factor 0.189 FT #SUB 196 226 HIS B 121 151 ALA A Protein S 6 FT #SUB 196 226 HIS B 122 152 GLN A Protein S 3 FT #SUB 223 253 LEU B 121 151 ALA A Protein S 3 FT #SUB 227 257 GLY B 120 150 PHE A Protein B 2 FT #SUB 227 257 GLY B 121 151 ALA A Protein B 3 FT #SUB 228 258 LYS B 119 149 VAL A Protein A 3 FT #SUB 228 258 LYS B 120 150 PHE A Protein S 2 FT #SUB 229 259 GLY B 118 148 SER A Protein B 3 FT #SUB 229 259 GLY B 119 149 VAL A Protein B 10 FT #SUB 230 260 THR B 44 74 LEU A Protein S 1 FT #SUB 230 260 THR B 116 146 ASP A Protein S 2 FT #SUB 230 260 THR B 117 147 SER A Protein A 3 FT #SUB 230 260 THR B 119 149 VAL A Protein B 2 FT #SUB 231 261 VAL B 116 146 ASP A Protein A 4 FT #SUB 231 261 VAL B 117 147 SER A Protein A 5 FT #SUB 231 261 VAL B 119 149 VAL A Protein S 1 FT #SUB 232 262 SER B 93 123 LEU A Protein S 3 FT #SUB 232 262 SER B 116 146 ASP A Protein A 10 FT #SUB 234 264 THR B 119 149 VAL A Protein S 1 FT #SUB 235 265 LEU B 85 115 PHE A Protein S 1 FT #SUB 236 266 ILE B 83 113 HIS A Protein S 6 FT #SUB 236 266 ILE B 85 115 PHE A Protein S 2 FT #SUB 238 268 LEU B 88 118 LEU A Protein A 3 FT #SUB 239 269 GLU B 83 113 HIS A Protein S 4 FT #SUB 239 269 GLU B 85 115 PHE A Protein S 5 FT #SUB 239 269 GLU B 86 116 HIS A Protein S 7 FT #SUB 239 269 GLU B 88 118 LEU A Protein B 2 FT #SUB 242 272 ARG B 87 117 GLY A Protein S 1 FT #SUB 242 272 ARG B 88 118 LEU A Protein S 2 FT #SUB 243 273 LYS B 86 116 HIS A Protein S 3 FT #SUB 258 288 PRO B 121 151 ALA A Protein B 2 FT #SUB 258 288 PRO B 122 152 GLN A Protein B 2 FT #SUB 259 289 LEU B 120 150 PHE A Protein A 3 FT #SUB 259 289 LEU B 122 152 GLN A Protein B 2 FT #SUB 260 290 ALA B 119 149 VAL A Protein B 3 FT #SUB 260 290 ALA B 120 150 PHE A Protein B 7 FT #SUB 260 290 ALA B 122 152 GLN A Protein A 3 FT #SUB 261 291 GLY B 42 72 TRP A Protein B 2 FT #SUB 261 291 GLY B 118 148 SER A Protein B 1 FT #SUB 262 292 GLY B 42 72 TRP A Protein B 2 FT #SUB 264 294 SER B 114 144 GLU A Protein A 6 FT #SUB 265 295 ARG B 33 63 THR A Protein S 1 FT #SUB 265 295 ARG B 35 65 HIS A Protein S 3 FT #SUB 265 295 ARG B 112 142 TYR A Protein A 18 FT #SUB 265 295 ARG B 114 144 GLU A Protein A 4 FT #SUB 266 296 VAL B 49 79 VAL A Protein S 1 FT #SUB 266 296 VAL B 51 81 VAL A Protein S 1 FT #SUB 266 296 VAL B 89 119 LEU A Protein A 2 FT #SUB 266 296 VAL B 112 142 TYR A Protein B 1 FT #SUB 266 296 VAL B 114 144 GLU A Protein A 7 FT #SUB 269 299 ALA B 89 119 LEU A Protein S 1 FT #SUB 269 299 ALA B 112 142 TYR A Protein S 1 FT #SUB 270 300 ALA B 89 119 LEU A Protein B 1 FT #SUB 273 303 ARG B 54 84 GLU A Protein S 6 FT #SUB 273 303 ARG B 88 118 LEU A Protein S 7 FT #SUB 273 303 ARG B 89 119 LEU A Protein S 6 FT #SUB 273 303 ARG B 90 120 PRO A Protein S 1 FT #SUB 274 304 LEU B 88 118 LEU A Protein A 3 FT #SUB 284 314 ALA B 122 152 GLN A Protein S 1 FT #SUB 286 316 GLY B 122 152 GLN A Protein B 3 FT #SUB 287 317 ASN B 122 152 GLN A Protein A 13 FT #SUB 288 318 PHE B 42 72 TRP A Protein S 4 FT #SUB 288 318 PHE B 122 152 GLN A Protein S 3 FT #SUB 294 324 LEU B 39 69 LYS A Protein B 1 FT #SUB 295 325 TYR B 39 69 LYS A Protein S 5 FT #SUB 354 384 GLY B 122 152 GLN A Protein B 2 FT #SUB 355 385 THR B 122 152 GLN A Protein A 3 FT #SUB 356 386 SER B 122 152 GLN A Protein A 11 FT #HET 263 293 TYR B 1 801 063 B S 3 FT #HET 293 323 CYS B 1 801 063 B A 6 FT #HET 298 328 ALA B 1 801 063 B B 2 FT #HET 299 329 SER B 1 801 063 B B 4 FT #HET 300 330 ALA B 1 801 063 B B 3 FT #HET 301 331 PRO B 1 801 063 B A 12 FT #HET 303 333 VAL B 1 801 063 B B 2 FT #HET 305 335 THR B 1 801 063 B S 1 FT #HET 327 357 ARG B 1 801 063 B A 18 FT #HET 328 358 CYS B 1 801 063 B A 17 FT #HET 329 359 VAL B 1 801 063 B B 1 FT #HET 330 360 ASP B 1 801 063 B S 11 FT #HET 382 412 ARG B 1 801 063 B S 2 FT #HET 428 458 ARG B 1 801 063 B S 6 FT #HET 430 460 VAL B 1 801 063 B S 3 FT #HET 431 461 TRP B 1 801 063 B B 2 FT #HET 433 463 ALA B 1 801 063 B S 1 FT #HET 444 474 ILE B 1 801 063 B B 2 FT #HET 445 475 ALA B 1 801 063 B B 2 FT #HET 446 476 ARG B 1 801 063 B A 17 FT #HET 447 477 CYS B 1 801 063 B B 3 FT #HET 448 478 ALA B 1 801 063 B A 7 FT #HET 476 506 LYS B 1 801 063 B S 3 FT DISORDER 1 122 FT DISORDER 138 147 FT DISORDER 183 189 FT DISORDER 513 517 FT DISORDER 541 553 FT DISORDER 587 589 FT DISORDER 610 611 FT DISORDER 630 640 FT DISORDER 653 707 CC SEQUENCE 479 AA (ATOM); CC SIPWNLERIT PPRYRSLVEV YLLDTSIQSD HREIEGRVMV TDFENVPEED ASKCDSHGTH CC LAGVVSGRDA GVAKGASMRS LRVLNCQGKG TVSGTLIGLE FIRKSQLVQP VGPLVVLLPL CC AGGYSRVLNA ACQRLARAGV VLVTAAGNFR DDACLYSPAS APEVITVGAT NAQDQPVTLG CC TLGTNFGRCV DLFAPGEDII GASSDCSTCF VSQSGTSQAA AHVAGIAAMM LSAEPELTLA CC ELRQRLIHFS AKDVINEAWF PEDQRVLTPN LVAALPPSTH GAGWQLFCRT VWSAHSGPTR CC MATAIARCAP DEELLSCSSF SRSGKRRGER MEAQGGKLVC RAHNAFGGEG VYAIARCCLL CC PQANCSVHTA PPATRVHCHQ QGHVLTGCSS HWEVEDQPNQ CVGHREASIH ASCCHAPGLE CC CKVKEHGIPE QVTVACEEGW TLTGCSALPS HVLGAYAVDN TCVVRSRAVT AVAICCRSR CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES QEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVV CC ATOM -------------------------------------------------- CC CC SEQRES VLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDL CC ATOM -------------------------------------------------- CC CC SEQRES LELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLV CC ATOM ----------------------SIPWNLERITPPRYR----------SLV CC *************** *** CC SEQRES EVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHL CC ATOM EVYLLDTSIQSDHREIEGRVMVTDFENVPEED-------ASKCDSHGTHL CC ******************************** *********** CC SEQRES AGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPV CC ATOM AGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPV CC ************************************************** CC SEQRES GPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASA CC ATOM GPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASA CC ************************************************** CC SEQRES PEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFV CC ATOM PEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFV CC ************************************************** CC SEQRES SQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFP CC ATOM SQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFP CC ************************************************** CC SEQRES EDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAIARCAPD CC ATOM EDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAIARCAPD CC ************************************************** CC SEQRES EELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLP CC ATOM EELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLP CC ************************************************** CC SEQRES QANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLR CC ATOM QANCSVHTAPPA-----TRVHCHQQGHVLTGCSSHWEVED---------- CC ************ *********************** CC SEQRES PRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTVACEEGW CC ATOM ---QPNQCVGHREASIHASCCHAPGLECKVKEHGIP---EQVTVACEEGW CC ********************************* *********** CC SEQRES TLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEEAVTAVAICCR CC ATOM TLTGCSALP--SHVLGAYAVDNTCVVRSR-----------AVTAVAICCR CC ********* ****************** ********** CC SEQRES SRHLAQASQELQKGNSADIQHSGGRSSLEGPRFEGKPIPNPLLGLDSTRT CC ATOM SR------------------------------------------------ CC ** CC SEQRES GHHHHHH CC ATOM ------- CC SQ SEQUENCE 707 AA; MW; CN; QEDEDGDYEE LVLALRSEED GLAEAPEHGT TATFHRCAKD PWRLPGTYVV VLKEETHLSQ SERTARRLQA QAARRGYLTK ILHVFHGLLP GFLVKMSGDL LELALKLPHV DYIEEDSSVF AQSIPWNLER ITPPRYRADE YQPPDGGSLV EVYLLDTSIQ SDHREIEGRV MVTDFENVPE EDGTRFHRQA SKCDSHGTHL AGVVSGRDAG VAKGASMRSL RVLNCQGKGT VSGTLIGLEF IRKSQLVQPV GPLVVLLPLA GGYSRVLNAA CQRLARAGVV LVTAAGNFRD DACLYSPASA PEVITVGATN AQDQPVTLGT LGTNFGRCVD LFAPGEDIIG ASSDCSTCFV SQSGTSQAAA HVAGIAAMML SAEPELTLAE LRQRLIHFSA KDVINEAWFP EDQRVLTPNL VAALPPSTHG AGWQLFCRTV WSAHSGPTRM ATAIARCAPD EELLSCSSFS RSGKRRGERM EAQGGKLVCR AHNAFGGEGV YAIARCCLLP QANCSVHTAP PAEASMGTRV HCHQQGHVLT GCSSHWEVED LGTHKPPVLR PRGQPNQCVG HREASIHASC CHAPGLECKV KEHGIPAPQE QVTVACEEGW TLTGCSALPG TSHVLGAYAV DNTCVVRSRD VSTTGSTSEE AVTAVAICCR SRHLAQASQE LQKGNSADIQ HSGGRSSLEG PRFEGKPIPN PLLGLDSTRT GHHHHHH //