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PDB ID: 6R49

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Ligands
Code Name Style Show Link
ADP Adenosine-5'-diphosphate PoSSuM
JSB (1~{S},10~{S})-12-cyclopropyl-1-oxidanyl-10-propan-2-yl-9,12-diazatricyclo[8.2.1.0^{2,7}]trideca-2(7),3,5-trien-11-one PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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TPO Phosphothreonine
Glycosylation
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Modification
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Structure summary

Code : 6R49   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Aurora-A in complex with shape-diverse fragment 39
Release Data : 2019-05-08
Compound :
mol_id molecule chains synonym
1 Aurora kinase A A Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A
ec: 2.7.11.1
mutation: C290A, C393A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
Authors : Bayliss, R., McIntyre, P.J.
Keywords : Ser/Thr kinase Allosteric site, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.209 Å )
Citation :

Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase.

Zhang, R.,McIntyre, P.J.,Collins, P.M.  et al.
(2019)  Chemistry  25 : 6831 - 6839

PubMed: 31026091
DOI: 10.1002/chem.201900815

Reaction

Chain : A
UniProt : O14965 (AURKA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27192185, PubMed:27837025, PubMed:28218735
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
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