Het-PDB Navi2 (PDB: 6Q9N)

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Ligands
Code	Name	Link
QLN	3-[2-[(~{E})-2-(4-ethynylphenyl)ethenyl]-4-oxidanylidene-quinazolin-3-yl]benzoic acid	PoSSuM
JPP	Piperacillin (open form)	PoSSuM
CL	Chloride ion	PoSSuM
CD	Cadmium ion	PoSSuM
MUR	Beta-muramic acid	PoSSuM

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Download interaction data: 6Q9N

Code :

6Q9N PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of PBP2a from MRSA in complex with piperacillin and quinazolinone

Release Data :

2019-11-27

Compound :

mol_id	molecule	chains
1	Penicillin binding protein 2 prime	A,B
	other_details: In chain A, the Ser is attached covalently to piperacillin (PA4 residue 403)

Source :

mol_id	organism_scientific	expression_system
1	Staphylococcus aureus (strain Mu50 / ATCC 700699) (taxid:158878)	Escherichia coli BL21(DE3) (taxid:469008)
	strain: Mu50 / ATCC 700699 gene: mecA, SAV0041

Authors :

Martinez-Caballero, S., Batuecas, M.T., Hermoso, J.A.

Keywords :

Penicillin Binding Protein, Hydrolase

Exp. method :

X-RAY DIFFRACTION ( 2.50 Å )

Citation :

The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus.

Janardhanan, J.,Bouley, R.,Martinez-Caballero, S. et al.
(2019) Antimicrob.Agents Chemother. 63

PDB ID: 6Q9N