Het-PDB Navi2 (PDB: 6HWO)

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Ligands
Code	Name	Link
EDO	1,2-ethanediol	PoSSuM
PEG	Di(hydroxyethyl)ether	PoSSuM
ZN	Zinc ion	PoSSuM
FFZ	3-[5-[(4ar,8as)-4-oxidanylidene-3-propan-2-yl-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxy-phenyl]-N-(phenylmethyl)prop-2-ynamide	PoSSuM
MG	Magnesium ion	PoSSuM
EPE	4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid	PoSSuM

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Download interaction data: 6HWO

Code :

6HWO PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1335

Release Data :

2019-07-24

Compound :

mol_id	molecule	chains	synonym
1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	A,B,C,D	DPDE3,PDE43
	ec: 3.1.4.53 other_details: residues 381-740

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: PDE4D, DPDE3 expression_system_variant: codon plus expression_system_vector_type: Plasmid expression_system_plasmid: pET15b

Authors :

Singh, A.K., Brown, D.G.

Keywords :

phosphodiesterase, hydrolase, cAMP hydrolysis, alternative splicing

Exp. method :

X-RAY DIFFRACTION ( 1.99 Å )

Citation :

Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).

de Heuvel, E.,Singh, A.K.,Boronat, P. et al.
(2019) Bioorg.Med.Chem. 27 : 4013 - 4029

Chain :

A, B, C, D

UniProt :

Q08499 (PDE4D_HUMAN)

PDB ID: 6HWO