Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
MG Magnesium ion
ZN Zinc ion
DMS Dimethyl sulfoxide
EDO 1,2-ethanediol
EPE 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid
FFZ 3-[5-[(4ar,8as)-4-oxidanylidene-3-propan-2-yl-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxy-phenyl]-N-(phenylmethyl)prop-2-ynamide
PEG Di(hydroxyethyl)ether
Code : 6HWO
Header : HYDROLASE
Title : Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1335
Release Data : 2019-07-24
Compound :
mol_id molecule chains synonym
1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D A,B,C,D DPDE3,PDE43
ec: 3.1.4.53
other_details: residues 381-740
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: PDE4D, DPDE3
expression_system_variant: codon plus
expression_system_vector_type: Plasmid
expression_system_plasmid: pET15b
Authors : Singh, A.K., Brown, D.G.
Keywords : phosphodiesterase, hydrolase, cAMP hydrolysis, alternative splicing
Exp. method : X-RAY DIFFRACTION ( 1.99 Å )
Citation :

Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).

de Heuvel, E.,Singh, A.K.,Boronat, P.  et al.
(2019)  Bioorg.Med.Chem.  27 : 4013 - 4029

PubMed: 31378593
DOI: 10.1016/j.bmc.2019.06.026

Chain : A, B, C, D
UniProt : Q08499 (PDE4D_HUMAN)
Reaction : Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.