ID 6HWOA STANDARD; PRT; 364 AA. DT CONVERTED FROM PDB (SEQRES) 6HWO DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.990 CC R-Factor 0.201 FT #SUB 146 220 ALA A 187 261 ARG B Protein B 1 FT #SUB 147 221 LEU A 187 261 ARG B Protein S 4 FT #SUB 148 222 MET A 149 223 TYR B Protein B 1 FT #SUB 149 223 TYR A 148 222 MET B Protein S 3 FT #SUB 150 224 ASN A 157 231 ASN B Protein S 5 FT #SUB 150 224 ASN A 160 234 LEU B Protein S 3 FT #SUB 150 224 ASN A 191 265 ILE B Protein A 3 FT #SUB 151 225 ASP A 187 261 ARG B Protein S 4 FT #SUB 157 231 ASN A 150 224 ASN B Protein A 7 FT #SUB 160 234 LEU A 150 224 ASN B Protein A 5 FT #SUB 161 235 ALA A 150 224 ASN B Protein B 1 FT #SUB 164 238 PHE A 147 221 LEU B Protein S 1 FT #SUB 180 254 LYS A 140 214 ASN B Protein S 3 FT #SUB 180 254 LYS A 142 216 ASN B Protein S 2 FT #SUB 184 258 GLN A 140 214 ASN B Protein S 4 FT #SUB 187 261 ARG A 146 220 ALA B Protein S 2 FT #SUB 187 261 ARG A 147 221 LEU B Protein S 2 FT #SUB 187 261 ARG A 150 224 ASN B Protein S 1 FT #SUB 187 261 ARG A 151 225 ASP B Protein S 12 FT #SUB 191 265 ILE A 150 224 ASN B Protein S 3 FT #SUB 42 116 ARG A 275 349 GLU C Protein S 8 FT #SUB 73 147 MET A 275 349 GLU C Protein S 5 FT #SUB 74 148 THR A 276 350 ARG C Protein A 6 FT #SUB 77 151 ASP A 272 346 ARG C Protein S 7 FT #SUB 77 151 ASP A 276 350 ARG C Protein S 5 FT #SUB 81 155 ALA A 82 156 ASP C Protein S 2 FT #SUB 82 156 ASP A 80 154 HIS C Protein S 1 FT #SUB 82 156 ASP A 81 155 ALA C Protein S 1 FT #SUB 82 156 ASP A 82 156 ASP C Protein S 2 FT #SUB 140 214 ASN A 170 244 GLU C Protein B 2 FT #SUB 141 215 THR A 169 243 GLU C Protein B 4 FT #SUB 141 215 THR A 170 244 GLU C Protein B 6 FT #SUB 142 216 ASN A 168 242 GLN C Protein S 2 FT #SUB 143 217 SER A 169 243 GLU C Protein A 2 FT #SUB 144 218 GLU A 165 239 LYS C Protein S 4 FT #SUB 165 239 LYS A 144 218 GLU C Protein S 3 FT #SUB 169 243 GLU A 141 215 THR C Protein A 6 FT #SUB 169 243 GLU A 276 350 ARG C Protein S 1 FT #SUB 170 244 GLU A 140 214 ASN C Protein S 2 FT #SUB 170 244 GLU A 141 215 THR C Protein A 6 FT #SUB 170 244 GLU A 142 216 ASN C Protein A 7 FT #SUB 268 342 ARG A 77 151 ASP C Protein S 2 FT #SUB 272 346 ARG A 77 151 ASP C Protein S 11 FT #SUB 275 349 GLU A 42 116 ARG C Protein S 3 FT #SUB 275 349 GLU A 70 144 THR C Protein B 1 FT #SUB 275 349 GLU A 73 147 MET C Protein S 6 FT #SUB 276 350 ARG A 70 144 THR C Protein A 2 FT #SUB 276 350 ARG A 73 147 MET C Protein S 3 FT #SUB 276 350 ARG A 74 148 THR C Protein S 4 FT #SUB 276 350 ARG A 77 151 ASP C Protein S 4 FT #SUB 165 239 LYS A 165 239 LYS D Protein S 2 FT #SUB 165 239 LYS A 168 242 GLN D Protein S 1 FT #SUB 168 242 GLN A 165 239 LYS D Protein S 1 FT #SUB 168 242 GLN A 168 242 GLN D Protein S 9 FT #SUB 170 244 GLU A 180 254 LYS D Protein S 7 FT #SUB 170 244 GLU A 183 257 ARG D Protein S 8 FT #SUB 180 254 LYS A 170 244 GLU D Protein S 8 FT #SUB 183 257 ARG A 170 244 GLU D Protein S 8 FT #HET 31 105 HIS A 20 520 EPE A A 12 FT #HET 32 106 VAL A 20 520 EPE A B 1 FT #HET 33 107 PHE A 20 520 EPE A A 6 FT #HET 34 108 ARG A 20 520 EPE A A 4 FT #HET 37 111 GLU A 20 520 EPE A S 15 FT #HET 41 115 ASN A 21 521 PEG A A 2 FT #HET 42 116 ARG A 21 521 PEG A S 1 FT #HET 58 132 LEU A 9 509 PEG A A 3 FT #HET 60 134 THR A 6 506 EDO A A 7 FT #HET 61 135 PHE A 5 505 EDO A S 3 FT #HET 62 136 LYS A 6 506 EDO A S 5 FT #HET 62 136 LYS A 9 509 PEG A A 6 FT #HET 63 137 ILE A 9 509 PEG A B 5 FT #HET 64 138 PRO A 9 509 PEG A A 2 FT #HET 64 138 PRO A 17 517 EDO A S 2 FT #HET 65 139 VAL A 9 509 PEG A B 1 FT #HET 66 140 ASP A 17 517 EDO A S 7 FT #HET 66 140 ASP A 50 513 EDO C S 1 FT #HET 67 141 THR A 17 517 EDO A S 1 FT #HET 69 143 ILE A 50 513 EDO C S 4 FT #HET 70 144 THR A 50 513 EDO C S 1 FT #HET 74 148 THR A 11 511 EDO A S 1 FT #HET 76 150 GLU A 21 521 PEG A B 3 FT #HET 77 151 ASP A 21 521 PEG A A 8 FT #HET 78 152 HIS A 11 511 EDO A S 6 FT #HET 78 152 HIS A 21 521 PEG A B 2 FT #HET 79 153 TYR A 21 521 PEG A B 7 FT #HET 80 154 HIS A 21 521 PEG A B 2 FT #HET 81 155 ALA A 21 521 PEG A A 3 FT #HET 82 156 ASP A 3 503 EDO A B 1 FT #HET 83 157 VAL A 3 503 EDO A A 4 FT #HET 84 158 ALA A 3 503 EDO A A 3 FT #HET 88 162 ASN A 21 521 PEG A S 1 FT #HET 90 164 HIS A 10 510 ZN A S 3 FT #HET 101 175 LEU A 7 507 EDO A S 2 FT #HET 104 178 THR A 7 507 EDO A S 5 FT #HET 112 186 THR A 12 512 EDO A S 4 FT #HET 114 188 LEU A 12 512 EDO A S 2 FT #HET 115 189 GLU A 12 512 EDO A S 4 FT #HET 126 200 HIS A 10 510 ZN A S 3 FT #HET 127 201 ASP A 10 510 ZN A S 3 FT #HET 127 201 ASP A 14 514 MG A S 3 FT #HET 131 205 PRO A 3 503 EDO A B 1 FT #HET 132 206 GLY A 3 503 EDO A B 1 FT #HET 136 210 GLN A 18 518 EDO A A 4 FT #HET 139 213 ILE A 18 518 EDO A S 1 FT #HET 144 218 GLU A 16 516 EDO A S 7 FT #HET 150 224 ASN A 35 514 EDO B B 1 FT #HET 151 225 ASP A 35 514 EDO B S 3 FT #HET 156 230 GLU A 14 514 MG A S 1 FT #HET 164 238 PHE A 2 502 EDO A S 4 FT #HET 167 241 LEU A 2 502 EDO A S 1 FT #HET 169 243 GLU A 11 511 EDO A S 8 FT #HET 169 243 GLU A 15 515 EDO A B 1 FT #HET 170 244 GLU A 15 515 EDO A A 6 FT #HET 170 244 GLU A 38 501 EDO C A 6 FT #HET 171 245 ASN A 15 515 EDO A B 5 FT #HET 171 245 ASN A 17 517 EDO A S 1 FT #HET 175 249 PHE A 2 502 EDO A S 3 FT #HET 177 251 ASN A 4 504 EDO A A 5 FT #HET 178 252 LEU A 4 504 EDO A B 2 FT #HET 179 253 THR A 4 504 EDO A A 2 FT #HET 182 256 GLN A 5 505 EDO A S 5 FT #HET 183 257 ARG A 2 502 EDO A S 5 FT #HET 184 258 GLN A 22 501 EDO B S 1 FT #HET 185 259 SER A 12 512 EDO A S 3 FT #HET 187 261 ARG A 2 502 EDO A S 1 FT #HET 188 262 LYS A 1 501 EDO A S 6 FT #HET 189 263 MET A 12 512 EDO A S 1 FT #HET 191 265 ILE A 1 501 EDO A S 1 FT #HET 192 266 ASP A 1 501 EDO A S 4 FT #HET 192 266 ASP A 8 508 EDO A B 1 FT #HET 195 269 LEU A 8 508 EDO A S 1 FT #HET 196 270 ALA A 8 508 EDO A B 1 FT #HET 199 273 MET A 13 513 FFZ A S 6 FT #HET 212 286 MET A 19 519 EDO A S 1 FT #HET 215 289 THR A 19 519 EDO A A 4 FT #HET 216 290 LYS A 19 519 EDO A B 2 FT #HET 217 291 LYS A 19 519 EDO A A 5 FT #HET 224 298 LEU A 19 519 EDO A S 1 FT #HET 225 299 LEU A 19 519 EDO A B 5 FT #HET 226 300 LEU A 19 519 EDO A S 2 FT #HET 237 311 GLN A 8 508 EDO A S 1 FT #HET 244 318 ASP A 10 510 ZN A S 3 FT #HET 244 318 ASP A 13 513 FFZ A S 2 FT #HET 245 319 LEU A 13 513 FFZ A S 1 FT #HET 254 328 LEU A 20 520 EPE A S 2 FT #HET 257 331 GLN A 20 520 EPE A S 2 FT #HET 259 333 THR A 13 513 FFZ A S 1 FT #HET 262 336 ILE A 13 513 FFZ A S 2 FT #HET 263 337 MET A 13 513 FFZ A S 3 FT #HET 265 339 GLU A 3 503 EDO A A 2 FT #HET 268 342 ARG A 3 503 EDO A S 3 FT #HET 268 342 ARG A 39 502 EDO C S 2 FT #HET 272 346 ARG A 3 503 EDO A S 5 FT #HET 283 357 MET A 13 513 FFZ A S 2 FT #HET 291 365 VAL A 13 513 FFZ A B 1 FT #HET 294 368 SER A 13 513 FFZ A A 13 FT #HET 295 369 GLN A 13 513 FFZ A A 14 FT #HET 298 372 PHE A 13 513 FFZ A A 21 FT #HET 302 376 ILE A 13 513 FFZ A S 2 FT #HET 310 384 TRP A 7 507 EDO A S 1 FT #HET 314 388 VAL A 7 507 EDO A S 1 FT #HET 317 391 ASP A 7 507 EDO A B 1 FT #HET 321 395 ILE A 7 507 EDO A S 1 FT DISORDER 1 8 FT DISORDER 336 364 CC SEQUENCE 327 AA (ATOM); CC GVKTEQEDVL AKELEDVNKW GLHVFRIAEL SGNRPLTVIM HTIFQERDLL KTFKIPVDTL CC ITYLMTLEDH YHADVAYHNN IHAADVVQST HVLLSTPALE AVFTDLEILA AIFASAIHDV CC DHPGVSNQFL INTNSELALM YNDSSVLENH HLAVGFKLLQ EENCDIFQNL TKKQRQSLRK CC MVIDIVLATD MSKHMNLLAD LKTMVETKKV TSSGVLLLDN YSDRIQVLQN MVHCADLSNP CC TKPLQLYRQW TDRIMEEFFR QGDRERERGM EISPMCDKHN ASVEKSQVGF IDYIVHPLWE CC TWADLVHPDA QDILDTLEDN REWYQST CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSHMIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT CC ATOM --------GVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT CC ****************************************** CC SEQRES IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHV CC ATOM IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHV CC ************************************************** CC SEQRES LLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYN CC ATOM LLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYN CC ************************************************** CC SEQRES DSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS CC ATOM DSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS CC ************************************************** CC SEQRES KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTK CC ATOM KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTK CC ************************************************** CC SEQRES PLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID CC ATOM PLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID CC ************************************************** CC SEQRES YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEG CC ATOM YIVHPLWETWADLVHPDAQDILDTLEDNREWYQST--------------- CC *********************************** CC SEQRES RQGQTEKFQFELTL CC ATOM -------------- CC SQ SEQUENCE 364 AA; MW; CN; GSHMIPRFGV KTEQEDVLAK ELEDVNKWGL HVFRIAELSG NRPLTVIMHT IFQERDLLKT FKIPVDTLIT YLMTLEDHYH ADVAYHNNIH AADVVQSTHV LLSTPALEAV FTDLEILAAI FASAIHDVDH PGVSNQFLIN TNSELALMYN DSSVLENHHL AVGFKLLQEE NCDIFQNLTK KQRQSLRKMV IDIVLATDMS KHMNLLADLK TMVETKKVTS SGVLLLDNYS DRIQVLQNMV HCADLSNPTK PLQLYRQWTD RIMEEFFRQG DRERERGMEI SPMCDKHNAS VEKSQVGFID YIVHPLWETW ADLVHPDAQD ILDTLEDNRE WYQSTIPQSP SPAPDDPEEG RQGQTEKFQF ELTL // ID 6HWOB STANDARD; PRT; 364 AA. DT CONVERTED FROM PDB (SEQRES) 6HWO DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.990 CC R-Factor 0.201 FT #SUB 140 214 ASN B 180 254 LYS A Protein B 3 FT #SUB 140 214 ASN B 184 258 GLN A Protein A 4 FT #SUB 142 216 ASN B 180 254 LYS A Protein S 2 FT #SUB 146 220 ALA B 187 261 ARG A Protein B 2 FT #SUB 147 221 LEU B 164 238 PHE A Protein S 1 FT #SUB 147 221 LEU B 187 261 ARG A Protein A 2 FT #SUB 148 222 MET B 149 223 TYR A Protein B 3 FT #SUB 149 223 TYR B 148 222 MET A Protein S 1 FT #SUB 150 224 ASN B 157 231 ASN A Protein S 7 FT #SUB 150 224 ASN B 160 234 LEU A Protein S 5 FT #SUB 150 224 ASN B 161 235 ALA A Protein S 1 FT #SUB 150 224 ASN B 187 261 ARG A Protein B 1 FT #SUB 150 224 ASN B 191 265 ILE A Protein B 3 FT #SUB 151 225 ASP B 187 261 ARG A Protein A 12 FT #SUB 157 231 ASN B 150 224 ASN A Protein A 5 FT #SUB 160 234 LEU B 150 224 ASN A Protein S 3 FT #SUB 187 261 ARG B 146 220 ALA A Protein S 1 FT #SUB 187 261 ARG B 147 221 LEU A Protein S 4 FT #SUB 187 261 ARG B 151 225 ASP A Protein S 4 FT #SUB 191 265 ILE B 150 224 ASN A Protein S 3 FT #SUB 170 244 GLU B 180 254 LYS C Protein S 5 FT #SUB 180 254 LYS B 170 244 GLU C Protein S 4 FT #SUB 42 116 ARG B 275 349 GLU D Protein S 9 FT #SUB 73 147 MET B 275 349 GLU D Protein S 7 FT #SUB 73 147 MET B 276 350 ARG D Protein S 3 FT #SUB 74 148 THR B 276 350 ARG D Protein A 7 FT #SUB 77 151 ASP B 272 346 ARG D Protein S 9 FT #SUB 77 151 ASP B 276 350 ARG D Protein S 3 FT #SUB 82 156 ASP B 81 155 ALA D Protein S 1 FT #SUB 82 156 ASP B 82 156 ASP D Protein S 2 FT #SUB 140 214 ASN B 170 244 GLU D Protein B 1 FT #SUB 141 215 THR B 169 243 GLU D Protein A 7 FT #SUB 141 215 THR B 170 244 GLU D Protein B 5 FT #SUB 142 216 ASN B 170 244 GLU D Protein S 7 FT #SUB 143 217 SER B 169 243 GLU D Protein A 2 FT #SUB 144 218 GLU B 165 239 LYS D Protein S 3 FT #SUB 165 239 LYS B 144 218 GLU D Protein S 5 FT #SUB 168 242 GLN B 142 216 ASN D Protein B 1 FT #SUB 169 243 GLU B 141 215 THR D Protein A 6 FT #SUB 169 243 GLU B 143 217 SER D Protein S 2 FT #SUB 170 244 GLU B 140 214 ASN D Protein S 2 FT #SUB 170 244 GLU B 141 215 THR D Protein A 5 FT #SUB 170 244 GLU B 142 216 ASN D Protein B 1 FT #SUB 268 342 ARG B 42 116 ARG D Protein S 1 FT #SUB 272 346 ARG B 77 151 ASP D Protein S 8 FT #SUB 275 349 GLU B 42 116 ARG D Protein S 9 FT #SUB 275 349 GLU B 73 147 MET D Protein A 3 FT #SUB 276 350 ARG B 74 148 THR D Protein S 6 FT #SUB 276 350 ARG B 77 151 ASP D Protein S 4 FT #HET 31 105 HIS B 37 516 EPE B A 7 FT #HET 32 106 VAL B 37 516 EPE B B 2 FT #HET 33 107 PHE B 37 516 EPE B A 5 FT #HET 34 108 ARG B 37 516 EPE B A 6 FT #HET 37 111 GLU B 37 516 EPE B S 7 FT #HET 41 115 ASN B 26 505 EDO B S 6 FT #HET 74 148 THR B 32 511 PEG B S 1 FT #HET 78 152 HIS B 32 511 PEG B S 6 FT #HET 81 155 ALA B 26 505 EDO B A 7 FT #HET 86 160 HIS B 33 512 FFZ B S 1 FT #HET 88 162 ASN B 26 505 EDO B S 6 FT #HET 89 163 ILE B 26 505 EDO B S 2 FT #HET 90 164 HIS B 29 508 ZN B S 3 FT #HET 101 175 LEU B 27 506 EDO B S 2 FT #HET 104 178 THR B 27 506 EDO B S 7 FT #HET 109 183 ALA B 24 503 EDO B B 2 FT #HET 110 184 VAL B 24 503 EDO B B 3 FT #HET 111 185 PHE B 24 503 EDO B B 1 FT #HET 112 186 THR B 24 503 EDO B S 1 FT #HET 126 200 HIS B 29 508 ZN B S 3 FT #HET 127 201 ASP B 29 508 ZN B S 3 FT #HET 127 201 ASP B 34 513 MG B S 3 FT #HET 135 209 ASN B 31 510 DMS B S 1 FT #HET 136 210 GLN B 22 501 EDO B S 8 FT #HET 136 210 GLN B 31 510 DMS B S 2 FT #HET 138 212 LEU B 54 503 EDO D S 1 FT #HET 139 213 ILE B 22 501 EDO B S 3 FT #HET 141 215 THR B 54 503 EDO D S 1 FT #HET 143 217 SER B 54 503 EDO D S 2 FT #HET 144 218 GLU B 30 509 EDO B S 5 FT #HET 144 218 GLU B 36 515 EDO B S 6 FT #HET 150 224 ASN B 1 501 EDO A B 1 FT #HET 152 226 SER B 1 501 EDO A S 1 FT #HET 169 243 GLU B 32 511 PEG B S 12 FT #HET 188 262 LYS B 35 514 EDO B S 7 FT #HET 191 265 ILE B 35 514 EDO B S 2 FT #HET 192 266 ASP B 35 514 EDO B S 4 FT #HET 199 273 MET B 33 512 FFZ B S 6 FT #HET 212 286 MET B 25 504 EDO B B 1 FT #HET 215 289 THR B 25 504 EDO B A 4 FT #HET 216 290 LYS B 25 504 EDO B B 5 FT #HET 217 291 LYS B 25 504 EDO B A 6 FT #HET 224 298 LEU B 25 504 EDO B S 1 FT #HET 225 299 LEU B 25 504 EDO B B 4 FT #HET 226 300 LEU B 25 504 EDO B S 2 FT #HET 244 318 ASP B 29 508 ZN B S 3 FT #HET 244 318 ASP B 33 512 FFZ B S 2 FT #HET 245 319 LEU B 33 512 FFZ B S 2 FT #HET 247 321 ASN B 33 512 FFZ B S 2 FT #HET 254 328 LEU B 37 516 EPE B S 2 FT #HET 257 331 GLN B 37 516 EPE B S 3 FT #HET 259 333 THR B 33 512 FFZ B A 2 FT #HET 260 334 ASP B 23 502 EDO B B 5 FT #HET 262 336 ILE B 33 512 FFZ B S 3 FT #HET 263 337 MET B 23 502 EDO B S 3 FT #HET 263 337 MET B 33 512 FFZ B S 1 FT #HET 264 338 GLU B 23 502 EDO B B 1 FT #HET 267 341 PHE B 23 502 EDO B S 2 FT #HET 275 349 GLU B 69 518 EDO D B 2 FT #HET 276 350 ARG B 54 503 EDO D S 1 FT #HET 276 350 ARG B 69 518 EDO D B 6 FT #HET 277 351 GLY B 69 518 EDO D B 1 FT #HET 283 357 MET B 33 512 FFZ B S 9 FT #HET 291 365 VAL B 23 502 EDO B S 1 FT #HET 291 365 VAL B 33 512 FFZ B B 1 FT #HET 294 368 SER B 33 512 FFZ B A 15 FT #HET 295 369 GLN B 33 512 FFZ B A 12 FT #HET 297 371 GLY B 33 512 FFZ B B 3 FT #HET 298 372 PHE B 33 512 FFZ B A 25 FT #HET 299 373 ILE B 28 507 EDO B S 1 FT #HET 300 374 ASP B 28 507 EDO B A 8 FT #HET 304 378 HIS B 28 507 EDO B S 9 FT #HET 310 384 TRP B 27 506 EDO B S 2 FT #HET 314 388 VAL B 27 506 EDO B S 2 FT #HET 317 391 ASP B 27 506 EDO B A 4 FT #HET 321 395 ILE B 27 506 EDO B S 1 FT #HET 329 403 ARG B 28 507 EDO B S 1 FT DISORDER 1 16 FT DISORDER 338 364 CC SEQUENCE 321 AA (ATOM); CC VLAKELEDVN KWGLHVFRIA ELSGNRPLTV IMHTIFQERD LLKTFKIPVD TLITYLMTLE CC DHYHADVAYH NNIHAADVVQ STHVLLSTPA LEAVFTDLEI LAAIFASAIH DVDHPGVSNQ CC FLINTNSELA LMYNDSSVLE NHHLAVGFKL LQEENCDIFQ NLTKKQRQSL RKMVIDIVLA CC TDMSKHMNLL ADLKTMVETK KVTSSGVLLL DNYSDRIQVL QNMVHCADLS NPTKPLQLYR CC QWTDRIMEEF FRQGDRERER GMEISPMCDK HNASVEKSQV GFIDYIVHPL WETWADLVHP CC DAQDILDTLE DNREWYQSTI P CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSHMIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT CC ATOM ----------------VLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT CC ********************************** CC SEQRES IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHV CC ATOM IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHV CC ************************************************** CC SEQRES LLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYN CC ATOM LLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYN CC ************************************************** CC SEQRES DSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS CC ATOM DSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS CC ************************************************** CC SEQRES KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTK CC ATOM KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTK CC ************************************************** CC SEQRES PLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID CC ATOM PLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID CC ************************************************** CC SEQRES YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEG CC ATOM YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIP------------- CC ************************************* CC SEQRES RQGQTEKFQFELTL CC ATOM -------------- CC SQ SEQUENCE 364 AA; MW; CN; GSHMIPRFGV KTEQEDVLAK ELEDVNKWGL HVFRIAELSG NRPLTVIMHT IFQERDLLKT FKIPVDTLIT YLMTLEDHYH ADVAYHNNIH AADVVQSTHV LLSTPALEAV FTDLEILAAI FASAIHDVDH PGVSNQFLIN TNSELALMYN DSSVLENHHL AVGFKLLQEE NCDIFQNLTK KQRQSLRKMV IDIVLATDMS KHMNLLADLK TMVETKKVTS SGVLLLDNYS DRIQVLQNMV HCADLSNPTK PLQLYRQWTD RIMEEFFRQG DRERERGMEI SPMCDKHNAS VEKSQVGFID YIVHPLWETW ADLVHPDAQD ILDTLEDNRE WYQSTIPQSP SPAPDDPEEG RQGQTEKFQF ELTL // ID 6HWOC STANDARD; PRT; 364 AA. DT CONVERTED FROM PDB (SEQRES) 6HWO DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.990 CC R-Factor 0.201 FT #SUB 42 116 ARG C 275 349 GLU A Protein S 3 FT #SUB 70 144 THR C 275 349 GLU A Protein S 1 FT #SUB 70 144 THR C 276 350 ARG A Protein S 2 FT #SUB 73 147 MET C 275 349 GLU A Protein S 6 FT #SUB 73 147 MET C 276 350 ARG A Protein A 3 FT #SUB 74 148 THR C 276 350 ARG A Protein A 4 FT #SUB 77 151 ASP C 268 342 ARG A Protein S 2 FT #SUB 77 151 ASP C 272 346 ARG A Protein S 11 FT #SUB 77 151 ASP C 276 350 ARG A Protein S 4 FT #SUB 80 154 HIS C 82 156 ASP A Protein B 1 FT #SUB 81 155 ALA C 82 156 ASP A Protein B 1 FT #SUB 82 156 ASP C 81 155 ALA A Protein S 2 FT #SUB 82 156 ASP C 82 156 ASP A Protein S 2 FT #SUB 140 214 ASN C 170 244 GLU A Protein B 2 FT #SUB 141 215 THR C 169 243 GLU A Protein A 6 FT #SUB 141 215 THR C 170 244 GLU A Protein B 6 FT #SUB 142 216 ASN C 170 244 GLU A Protein S 7 FT #SUB 144 218 GLU C 165 239 LYS A Protein S 3 FT #SUB 165 239 LYS C 144 218 GLU A Protein S 4 FT #SUB 168 242 GLN C 142 216 ASN A Protein B 2 FT #SUB 169 243 GLU C 141 215 THR A Protein A 4 FT #SUB 169 243 GLU C 143 217 SER A Protein S 2 FT #SUB 170 244 GLU C 140 214 ASN A Protein S 2 FT #SUB 170 244 GLU C 141 215 THR A Protein A 6 FT #SUB 272 346 ARG C 77 151 ASP A Protein S 7 FT #SUB 275 349 GLU C 42 116 ARG A Protein S 8 FT #SUB 275 349 GLU C 73 147 MET A Protein S 5 FT #SUB 276 350 ARG C 74 148 THR A Protein S 6 FT #SUB 276 350 ARG C 77 151 ASP A Protein S 5 FT #SUB 276 350 ARG C 169 243 GLU A Protein S 1 FT #SUB 170 244 GLU C 180 254 LYS B Protein S 4 FT #SUB 180 254 LYS C 170 244 GLU B Protein S 5 FT #SUB 140 214 ASN C 180 254 LYS D Protein B 3 FT #SUB 140 214 ASN C 184 258 GLN D Protein A 5 FT #SUB 142 216 ASN C 180 254 LYS D Protein S 3 FT #SUB 146 220 ALA C 187 261 ARG D Protein B 2 FT #SUB 147 221 LEU C 168 242 GLN D Protein S 1 FT #SUB 147 221 LEU C 187 261 ARG D Protein B 1 FT #SUB 148 222 MET C 149 223 TYR D Protein B 3 FT #SUB 149 223 TYR C 148 222 MET D Protein S 1 FT #SUB 150 224 ASN C 157 231 ASN D Protein S 9 FT #SUB 150 224 ASN C 160 234 LEU D Protein S 4 FT #SUB 150 224 ASN C 161 235 ALA D Protein S 1 FT #SUB 150 224 ASN C 187 261 ARG D Protein B 1 FT #SUB 150 224 ASN C 191 265 ILE D Protein B 2 FT #SUB 151 225 ASP C 187 261 ARG D Protein A 12 FT #SUB 151 225 ASP C 191 265 ILE D Protein S 1 FT #SUB 157 231 ASN C 150 224 ASN D Protein S 1 FT #SUB 187 261 ARG C 147 221 LEU D Protein S 4 FT #SUB 187 261 ARG C 151 225 ASP D Protein S 3 FT #SUB 191 265 ILE C 150 224 ASN D Protein S 4 FT #HET 31 105 HIS C 40 503 EPE C A 10 FT #HET 32 106 VAL C 40 503 EPE C B 1 FT #HET 33 107 PHE C 40 503 EPE C A 6 FT #HET 34 108 ARG C 40 503 EPE C A 6 FT #HET 37 111 GLU C 40 503 EPE C S 12 FT #HET 41 115 ASN C 39 502 EDO C A 4 FT #HET 60 134 THR C 43 506 EDO C B 2 FT #HET 61 135 PHE C 43 506 EDO C A 2 FT #HET 62 136 LYS C 43 506 EDO C S 4 FT #HET 76 150 GLU C 39 502 EDO C A 4 FT #HET 77 151 ASP C 39 502 EDO C A 4 FT #HET 79 153 TYR C 39 502 EDO C B 3 FT #HET 80 154 HIS C 44 507 EDO C S 2 FT #HET 82 156 ASP C 21 521 PEG A S 1 FT #HET 82 156 ASP C 45 508 EDO C B 1 FT #HET 83 157 VAL C 45 508 EDO C B 2 FT #HET 84 158 ALA C 45 508 EDO C B 1 FT #HET 86 160 HIS C 47 510 FFZ C S 1 FT #HET 88 162 ASN C 39 502 EDO C S 4 FT #HET 90 164 HIS C 46 509 ZN C S 3 FT #HET 126 200 HIS C 46 509 ZN C S 3 FT #HET 127 201 ASP C 46 509 ZN C S 3 FT #HET 127 201 ASP C 49 512 MG C S 3 FT #HET 129 203 ASP C 44 507 EDO C A 7 FT #HET 131 205 PRO C 44 507 EDO C S 4 FT #HET 131 205 PRO C 45 508 EDO C B 1 FT #HET 138 212 LEU C 11 511 EDO A S 1 FT #HET 139 213 ILE C 48 511 PEG C S 1 FT #HET 140 214 ASN C 38 501 EDO C A 5 FT #HET 141 215 THR C 11 511 EDO A S 1 FT #HET 141 215 THR C 38 501 EDO C B 1 FT #HET 143 217 SER C 11 511 EDO A S 1 FT #HET 145 219 LEU C 44 507 EDO C S 1 FT #HET 151 225 ASP C 48 511 PEG C S 9 FT #HET 157 231 ASN C 68 517 EDO D A 4 FT #HET 160 234 LEU C 68 517 EDO D S 3 FT #HET 161 235 ALA C 16 516 EDO A S 1 FT #HET 162 236 VAL C 16 516 EDO A S 1 FT #HET 165 239 LYS C 16 516 EDO A S 3 FT #HET 177 251 ASN C 43 506 EDO C B 4 FT #HET 179 253 THR C 51 514 EDO C A 4 FT #HET 180 254 LYS C 51 514 EDO C A 5 FT #HET 182 256 GLN C 43 506 EDO C S 5 FT #HET 188 262 LYS C 41 504 EDO C S 6 FT #HET 191 265 ILE C 41 504 EDO C S 1 FT #HET 192 266 ASP C 41 504 EDO C S 4 FT #HET 192 266 ASP C 42 505 EDO C B 1 FT #HET 195 269 LEU C 42 505 EDO C A 4 FT #HET 196 270 ALA C 42 505 EDO C B 1 FT #HET 199 273 MET C 47 510 FFZ C S 6 FT #HET 201 275 LYS C 42 505 EDO C S 2 FT #HET 237 311 GLN C 42 505 EDO C S 1 FT #HET 244 318 ASP C 46 509 ZN C S 3 FT #HET 244 318 ASP C 47 510 FFZ C S 1 FT #HET 245 319 LEU C 47 510 FFZ C S 1 FT #HET 247 321 ASN C 47 510 FFZ C S 2 FT #HET 253 327 GLN C 40 503 EPE C S 4 FT #HET 254 328 LEU C 40 503 EPE C S 2 FT #HET 257 331 GLN C 40 503 EPE C S 4 FT #HET 259 333 THR C 47 510 FFZ C S 1 FT #HET 262 336 ILE C 47 510 FFZ C S 9 FT #HET 263 337 MET C 47 510 FFZ C S 1 FT #HET 265 339 GLU C 45 508 EDO C A 3 FT #HET 268 342 ARG C 45 508 EDO C S 6 FT #HET 272 346 ARG C 45 508 EDO C S 1 FT #HET 275 349 GLU C 50 513 EDO C B 2 FT #HET 276 350 ARG C 11 511 EDO A S 4 FT #HET 276 350 ARG C 38 501 EDO C A 4 FT #HET 278 352 MET C 38 501 EDO C S 4 FT #HET 283 357 MET C 47 510 FFZ C S 1 FT #HET 291 365 VAL C 47 510 FFZ C B 1 FT #HET 294 368 SER C 47 510 FFZ C A 14 FT #HET 295 369 GLN C 47 510 FFZ C A 14 FT #HET 297 371 GLY C 47 510 FFZ C B 1 FT #HET 298 372 PHE C 47 510 FFZ C A 21 FT DISORDER 1 12 FT DISORDER 337 364 CC SEQUENCE 324 AA (ATOM); CC EQEDVLAKEL EDVNKWGLHV FRIAELSGNR PLTVIMHTIF QERDLLKTFK IPVDTLITYL CC MTLEDHYHAD VAYHNNIHAA DVVQSTHVLL STPALEAVFT DLEILAAIFA SAIHDVDHPG CC VSNQFLINTN SELALMYNDS SVLENHHLAV GFKLLQEENC DIFQNLTKKQ RQSLRKMVID CC IVLATDMSKH MNLLADLKTM VETKKVTSSG VLLLDNYSDR IQVLQNMVHC ADLSNPTKPL CC QLYRQWTDRI MEEFFRQGDR ERERGMEISP MCDKHNASVE KSQVGFIDYI VHPLWETWAD CC LVHPDAQDIL DTLEDNREWY QSTI CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSHMIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT CC ATOM ------------EQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT CC ************************************** CC SEQRES IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHV CC ATOM IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHV CC ************************************************** CC SEQRES LLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYN CC ATOM LLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYN CC ************************************************** CC SEQRES DSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS CC ATOM DSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS CC ************************************************** CC SEQRES KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTK CC ATOM KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTK CC ************************************************** CC SEQRES PLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID CC ATOM PLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID CC ************************************************** CC SEQRES YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEG CC ATOM YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTI-------------- CC ************************************ CC SEQRES RQGQTEKFQFELTL CC ATOM -------------- CC SQ SEQUENCE 364 AA; MW; CN; GSHMIPRFGV KTEQEDVLAK ELEDVNKWGL HVFRIAELSG NRPLTVIMHT IFQERDLLKT FKIPVDTLIT YLMTLEDHYH ADVAYHNNIH AADVVQSTHV LLSTPALEAV FTDLEILAAI FASAIHDVDH PGVSNQFLIN TNSELALMYN DSSVLENHHL AVGFKLLQEE NCDIFQNLTK KQRQSLRKMV IDIVLATDMS KHMNLLADLK TMVETKKVTS SGVLLLDNYS DRIQVLQNMV HCADLSNPTK PLQLYRQWTD RIMEEFFRQG DRERERGMEI SPMCDKHNAS VEKSQVGFID YIVHPLWETW ADLVHPDAQD ILDTLEDNRE WYQSTIPQSP SPAPDDPEEG RQGQTEKFQF ELTL // ID 6HWOD STANDARD; PRT; 364 AA. DT CONVERTED FROM PDB (SEQRES) 6HWO DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.990 CC R-Factor 0.201 FT #SUB 165 239 LYS D 165 239 LYS A Protein S 2 FT #SUB 165 239 LYS D 168 242 GLN A Protein S 1 FT #SUB 168 242 GLN D 165 239 LYS A Protein S 1 FT #SUB 168 242 GLN D 168 242 GLN A Protein S 9 FT #SUB 170 244 GLU D 180 254 LYS A Protein S 8 FT #SUB 170 244 GLU D 183 257 ARG A Protein S 8 FT #SUB 180 254 LYS D 170 244 GLU A Protein S 7 FT #SUB 183 257 ARG D 170 244 GLU A Protein S 8 FT #SUB 42 116 ARG D 268 342 ARG B Protein S 1 FT #SUB 42 116 ARG D 275 349 GLU B Protein S 9 FT #SUB 73 147 MET D 275 349 GLU B Protein S 3 FT #SUB 74 148 THR D 276 350 ARG B Protein A 6 FT #SUB 77 151 ASP D 272 346 ARG B Protein S 8 FT #SUB 77 151 ASP D 276 350 ARG B Protein S 4 FT #SUB 81 155 ALA D 82 156 ASP B Protein S 1 FT #SUB 82 156 ASP D 82 156 ASP B Protein S 2 FT #SUB 140 214 ASN D 170 244 GLU B Protein B 2 FT #SUB 141 215 THR D 169 243 GLU B Protein B 6 FT #SUB 141 215 THR D 170 244 GLU B Protein B 5 FT #SUB 142 216 ASN D 168 242 GLN B Protein S 1 FT #SUB 142 216 ASN D 170 244 GLU B Protein S 1 FT #SUB 143 217 SER D 169 243 GLU B Protein A 2 FT #SUB 144 218 GLU D 165 239 LYS B Protein S 5 FT #SUB 165 239 LYS D 144 218 GLU B Protein S 3 FT #SUB 169 243 GLU D 141 215 THR B Protein A 7 FT #SUB 169 243 GLU D 143 217 SER B Protein S 2 FT #SUB 170 244 GLU D 140 214 ASN B Protein S 1 FT #SUB 170 244 GLU D 141 215 THR B Protein A 5 FT #SUB 170 244 GLU D 142 216 ASN B Protein A 7 FT #SUB 272 346 ARG D 77 151 ASP B Protein S 9 FT #SUB 275 349 GLU D 42 116 ARG B Protein S 9 FT #SUB 275 349 GLU D 73 147 MET B Protein A 7 FT #SUB 276 350 ARG D 73 147 MET B Protein A 3 FT #SUB 276 350 ARG D 74 148 THR B Protein S 7 FT #SUB 276 350 ARG D 77 151 ASP B Protein S 3 FT #SUB 147 221 LEU D 187 261 ARG C Protein S 4 FT #SUB 148 222 MET D 149 223 TYR C Protein B 1 FT #SUB 149 223 TYR D 148 222 MET C Protein S 3 FT #SUB 150 224 ASN D 157 231 ASN C Protein S 1 FT #SUB 150 224 ASN D 191 265 ILE C Protein S 4 FT #SUB 151 225 ASP D 187 261 ARG C Protein S 3 FT #SUB 157 231 ASN D 150 224 ASN C Protein A 9 FT #SUB 160 234 LEU D 150 224 ASN C Protein S 4 FT #SUB 161 235 ALA D 150 224 ASN C Protein B 1 FT #SUB 168 242 GLN D 147 221 LEU C Protein S 1 FT #SUB 180 254 LYS D 140 214 ASN C Protein S 3 FT #SUB 180 254 LYS D 142 216 ASN C Protein S 3 FT #SUB 184 258 GLN D 140 214 ASN C Protein S 5 FT #SUB 187 261 ARG D 146 220 ALA C Protein S 2 FT #SUB 187 261 ARG D 147 221 LEU C Protein S 1 FT #SUB 187 261 ARG D 150 224 ASN C Protein S 1 FT #SUB 187 261 ARG D 151 225 ASP C Protein S 12 FT #SUB 191 265 ILE D 150 224 ASN C Protein S 2 FT #SUB 191 265 ILE D 151 225 ASP C Protein S 1 FT #HET 24 98 ASP D 64 513 EDO D S 2 FT #HET 26 100 ASN D 59 508 EDO D B 2 FT #HET 27 101 LYS D 59 508 EDO D B 2 FT #HET 27 101 LYS D 64 513 EDO D S 1 FT #HET 28 102 TRP D 59 508 EDO D A 4 FT #HET 28 102 TRP D 64 513 EDO D B 2 FT #HET 29 103 GLY D 64 513 EDO D B 2 FT #HET 31 105 HIS D 74 523 EPE D A 11 FT #HET 32 106 VAL D 74 523 EPE D B 1 FT #HET 33 107 PHE D 74 523 EPE D A 7 FT #HET 34 108 ARG D 74 523 EPE D A 6 FT #HET 37 111 GLU D 74 523 EPE D S 14 FT #HET 49 123 HIS D 60 509 EDO D S 3 FT #HET 58 132 LEU D 75 524 PEG D A 3 FT #HET 60 134 THR D 62 511 EDO D B 3 FT #HET 61 135 PHE D 62 511 EDO D B 4 FT #HET 62 136 LYS D 62 511 EDO D S 1 FT #HET 62 136 LYS D 75 524 PEG D B 3 FT #HET 63 137 ILE D 75 524 PEG D B 7 FT #HET 64 138 PRO D 75 524 PEG D B 3 FT #HET 65 139 VAL D 75 524 PEG D A 6 FT #HET 69 143 ILE D 69 518 EDO D S 3 FT #HET 70 144 THR D 69 518 EDO D S 1 FT #HET 74 148 THR D 54 503 EDO D S 1 FT #HET 76 150 GLU D 58 507 DMS D A 6 FT #HET 77 151 ASP D 58 507 DMS D A 4 FT #HET 78 152 HIS D 30 509 EDO B S 3 FT #HET 78 152 HIS D 54 503 EDO D S 4 FT #HET 79 153 TYR D 58 507 DMS D A 5 FT #HET 82 156 ASP D 61 510 EDO D B 2 FT #HET 83 157 VAL D 61 510 EDO D B 3 FT #HET 84 158 ALA D 61 510 EDO D A 4 FT #HET 86 160 HIS D 66 515 FFZ D S 1 FT #HET 88 162 ASN D 58 507 DMS D S 4 FT #HET 90 164 HIS D 63 512 ZN D S 3 FT #HET 100 174 VAL D 56 505 EDO D S 1 FT #HET 100 174 VAL D 59 508 EDO D S 2 FT #HET 101 175 LEU D 56 505 EDO D S 2 FT #HET 103 177 SER D 53 502 DMS D B 4 FT #HET 104 178 THR D 53 502 DMS D B 1 FT #HET 104 178 THR D 56 505 EDO D S 5 FT #HET 105 179 PRO D 53 502 DMS D A 6 FT #HET 105 179 PRO D 55 504 EDO D S 3 FT #HET 107 181 LEU D 57 506 EDO D B 2 FT #HET 108 182 GLU D 52 501 EDO D S 8 FT #HET 108 182 GLU D 53 502 DMS D S 5 FT #HET 108 182 GLU D 57 506 EDO D A 3 FT #HET 109 183 ALA D 57 506 EDO D B 7 FT #HET 109 183 ALA D 73 522 EDO D B 3 FT #HET 110 184 VAL D 57 506 EDO D B 3 FT #HET 110 184 VAL D 73 522 EDO D B 2 FT #HET 111 185 PHE D 57 506 EDO D A 7 FT #HET 111 185 PHE D 73 522 EDO D B 1 FT #HET 112 186 THR D 72 521 EDO D S 3 FT #HET 115 189 GLU D 72 521 EDO D S 8 FT #HET 116 190 ILE D 57 506 EDO D S 1 FT #HET 126 200 HIS D 63 512 ZN D S 3 FT #HET 127 201 ASP D 63 512 ZN D S 3 FT #HET 127 201 ASP D 67 516 MG D S 3 FT #HET 141 215 THR D 32 511 PEG B S 1 FT #HET 143 217 SER D 32 511 PEG B S 2 FT #HET 144 218 GLU D 32 511 PEG B A 4 FT #HET 145 219 LEU D 32 511 PEG B A 4 FT #HET 147 221 LEU D 68 517 EDO D B 4 FT #HET 148 222 MET D 68 517 EDO D B 4 FT #HET 150 224 ASN D 41 504 EDO C B 2 FT #HET 150 224 ASN D 68 517 EDO D S 6 FT #HET 152 226 SER D 41 504 EDO C S 1 FT #HET 156 230 GLU D 67 516 MG D S 1 FT #HET 161 235 ALA D 36 515 EDO B S 1 FT #HET 164 238 PHE D 70 519 EDO D S 4 FT #HET 165 239 LYS D 30 509 EDO B S 1 FT #HET 165 239 LYS D 36 515 EDO B S 3 FT #HET 167 241 LEU D 70 519 EDO D S 1 FT #HET 169 243 GLU D 54 503 EDO D S 11 FT #HET 175 249 PHE D 70 519 EDO D S 3 FT #HET 177 251 ASN D 62 511 EDO D B 3 FT #HET 179 253 THR D 62 511 EDO D S 1 FT #HET 180 254 LYS D 38 501 EDO C S 1 FT #HET 182 256 GLN D 62 511 EDO D S 5 FT #HET 183 257 ARG D 15 515 EDO A S 4 FT #HET 183 257 ARG D 70 519 EDO D A 6 FT #HET 184 258 GLN D 48 511 PEG C B 5 FT #HET 185 259 SER D 72 521 EDO D S 1 FT #HET 187 261 ARG D 48 511 PEG C S 3 FT #HET 187 261 ARG D 70 519 EDO D S 2 FT #HET 188 262 LYS D 48 511 PEG C A 9 FT #HET 189 263 MET D 72 521 EDO D S 3 FT #HET 191 265 ILE D 48 511 PEG C S 2 FT #HET 192 266 ASP D 65 514 EDO D B 1 FT #HET 195 269 LEU D 65 514 EDO D A 3 FT #HET 196 270 ALA D 65 514 EDO D B 1 FT #HET 199 273 MET D 66 515 FFZ D S 7 FT #HET 212 286 MET D 71 520 EDO D B 1 FT #HET 215 289 THR D 71 520 EDO D B 2 FT #HET 216 290 LYS D 71 520 EDO D A 6 FT #HET 217 291 LYS D 71 520 EDO D A 10 FT #HET 224 298 LEU D 71 520 EDO D S 2 FT #HET 225 299 LEU D 71 520 EDO D B 4 FT #HET 229 303 TYR D 72 521 EDO D S 1 FT #HET 237 311 GLN D 65 514 EDO D S 1 FT #HET 244 318 ASP D 63 512 ZN D S 3 FT #HET 244 318 ASP D 66 515 FFZ D S 2 FT #HET 245 319 LEU D 66 515 FFZ D S 1 FT #HET 247 321 ASN D 66 515 FFZ D S 3 FT #HET 253 327 GLN D 74 523 EPE D S 7 FT #HET 254 328 LEU D 74 523 EPE D S 2 FT #HET 257 331 GLN D 74 523 EPE D S 2 FT #HET 262 336 ILE D 66 515 FFZ D S 2 FT #HET 265 339 GLU D 61 510 EDO D A 2 FT #HET 268 342 ARG D 61 510 EDO D S 3 FT #HET 276 350 ARG D 32 511 PEG B S 1 FT #HET 283 357 MET D 66 515 FFZ D S 1 FT #HET 294 368 SER D 66 515 FFZ D A 10 FT #HET 295 369 GLN D 66 515 FFZ D A 11 FT #HET 297 371 GLY D 66 515 FFZ D B 2 FT #HET 298 372 PHE D 66 515 FFZ D A 21 FT #HET 310 384 TRP D 56 505 EDO D S 1 FT #HET 314 388 VAL D 56 505 EDO D S 1 FT #HET 317 391 ASP D 55 504 EDO D A 6 FT #HET 317 391 ASP D 56 505 EDO D A 3 FT #HET 318 392 ALA D 56 505 EDO D S 1 FT #HET 321 395 ILE D 56 505 EDO D S 2 FT DISORDER 1 13 FT DISORDER 338 364 CC SEQUENCE 324 AA (ATOM); CC QEDVLAKELE DVNKWGLHVF RIAELSGNRP LTVIMHTIFQ ERDLLKTFKI PVDTLITYLM CC TLEDHYHADV AYHNNIHAAD VVQSTHVLLS TPALEAVFTD LEILAAIFAS AIHDVDHPGV CC SNQFLINTNS ELALMYNDSS VLENHHLAVG FKLLQEENCD IFQNLTKKQR QSLRKMVIDI CC VLATDMSKHM NLLADLKTMV ETKKVTSSGV LLLDNYSDRI QVLQNMVHCA DLSNPTKPLQ CC LYRQWTDRIM EEFFRQGDRE RERGMEISPM CDKHNASVEK SQVGFIDYIV HPLWETWADL CC VHPDAQDILD TLEDNREWYQ STIP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSHMIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT CC ATOM -------------QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT CC ************************************* CC SEQRES IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHV CC ATOM IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHV CC ************************************************** CC SEQRES LLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYN CC ATOM LLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYN CC ************************************************** CC SEQRES DSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS CC ATOM DSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS CC ************************************************** CC SEQRES KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTK CC ATOM KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTK CC ************************************************** CC SEQRES PLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID CC ATOM PLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID CC ************************************************** CC SEQRES YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEG CC ATOM YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIP------------- CC ************************************* CC SEQRES RQGQTEKFQFELTL CC ATOM -------------- CC SQ SEQUENCE 364 AA; MW; CN; GSHMIPRFGV KTEQEDVLAK ELEDVNKWGL HVFRIAELSG NRPLTVIMHT IFQERDLLKT FKIPVDTLIT YLMTLEDHYH ADVAYHNNIH AADVVQSTHV LLSTPALEAV FTDLEILAAI FASAIHDVDH PGVSNQFLIN TNSELALMYN DSSVLENHHL AVGFKLLQEE NCDIFQNLTK KQRQSLRKMV IDIVLATDMS KHMNLLADLK TMVETKKVTS SGVLLLDNYS DRIQVLQNMV HCADLSNPTK PLQLYRQWTD RIMEEFFRQG DRERERGMEI SPMCDKHNAS VEKSQVGFID YIVHPLWETW ADLVHPDAQD ILDTLEDNRE WYQSTIPQSP SPAPDDPEEG RQGQTEKFQF ELTL //