Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
MG Magnesium ion
ZN Zinc ion
CZQ 2-[(~{E})-[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]methylideneamino]oxy-1-[(2~{R},6~{R})-2,6-dimethylmorpholin-4-yl]ethanone
Code : 6F8U
Header : HYDROLASE
Title : Crystal structure of the PDE4D catalytic domain in complex with GEBR-20b
Release Data : 2018-05-16
Compound :
mol_id molecule chains synonym
1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D A,B DPDE3,PDE43
ec: 3.1.4.53
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: PDE4D, DPDE3
Authors : Prosdocimi, T., Donini, S., Parisini, E.
Keywords : PDE4, catalytic domain, inhibitor, GEBR, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.100 Å )
Citation :

Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.

Prosdocimi, T.,Mollica, L.,Donini, S.  et al.
(2018)  Biochemistry  57 : 2876 - 2888

PubMed: 29652483
DOI: 10.1021/acs.biochem.8b00288

Chain : A, B
UniProt : Q08499 (PDE4D_HUMAN)
Reaction : Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.