ID 6F8UA STANDARD; PRT; 343 AA. DT CONVERTED FROM PDB (SEQRES) 6F8U DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.100 CC R-Factor 0.168 FT #SUB 142 384 GLU A 163 405 LYS B Protein S 4 FT #SUB 142 384 GLU A 166 408 GLN B Protein S 2 FT #SUB 144 386 ALA A 185 427 ARG B Protein B 2 FT #SUB 145 387 LEU A 159 401 ALA B Protein B 2 FT #SUB 145 387 LEU A 162 404 PHE B Protein S 1 FT #SUB 145 387 LEU A 163 405 LYS B Protein S 2 FT #SUB 145 387 LEU A 166 408 GLN B Protein S 1 FT #SUB 145 387 LEU A 185 427 ARG B Protein S 1 FT #SUB 146 388 MET A 146 388 MET B Protein S 3 FT #SUB 146 388 MET A 147 389 TYR B Protein A 9 FT #SUB 147 389 TYR A 146 388 MET B Protein S 6 FT #SUB 147 389 TYR A 147 389 TYR B Protein S 4 FT #SUB 148 390 ASN A 155 397 ASN B Protein S 7 FT #SUB 148 390 ASN A 158 400 LEU B Protein S 8 FT #SUB 148 390 ASN A 159 401 ALA B Protein S 1 FT #SUB 148 390 ASN A 185 427 ARG B Protein B 2 FT #SUB 148 390 ASN A 189 431 ILE B Protein A 3 FT #SUB 149 391 ASP A 185 427 ARG B Protein A 11 FT #SUB 155 397 ASN A 148 390 ASN B Protein A 7 FT #SUB 158 400 LEU A 148 390 ASN B Protein S 6 FT #SUB 159 401 ALA A 145 387 LEU B Protein A 2 FT #SUB 159 401 ALA A 146 388 MET B Protein S 1 FT #SUB 159 401 ALA A 148 390 ASN B Protein B 1 FT #SUB 162 404 PHE A 145 387 LEU B Protein S 1 FT #SUB 163 405 LYS A 145 387 LEU B Protein A 2 FT #SUB 185 427 ARG A 144 386 ALA B Protein S 2 FT #SUB 185 427 ARG A 145 387 LEU B Protein S 1 FT #SUB 185 427 ARG A 148 390 ASN B Protein S 2 FT #SUB 185 427 ARG A 149 391 ASP B Protein S 11 FT #SUB 189 431 ILE A 148 390 ASN B Protein S 3 FT #HET 83 325 TYR A 6 606 CZQ A S 7 FT #HET 88 330 HIS A 1 601 ZN A S 3 FT #HET 124 366 HIS A 1 601 ZN A S 3 FT #HET 125 367 ASP A 1 601 ZN A S 3 FT #HET 125 367 ASP A 2 602 MG A S 3 FT #HET 132 374 SER A 6 606 CZQ A A 11 FT #HET 197 439 MET A 6 606 CZQ A S 2 FT #HET 225 467 ASP A 4 604 MG A A 4 FT #HET 229 471 ASP A 4 604 MG A S 3 FT #HET 242 484 ASP A 1 601 ZN A S 3 FT #HET 245 487 ASN A 6 606 CZQ A S 10 FT #HET 246 488 PRO A 6 606 CZQ A S 2 FT #HET 253 495 TYR A 6 606 CZQ A S 5 FT #HET 256 498 TRP A 6 606 CZQ A A 3 FT #HET 257 499 THR A 6 606 CZQ A A 10 FT #HET 260 502 ILE A 6 606 CZQ A S 9 FT #HET 261 503 MET A 6 606 CZQ A S 1 FT #HET 264 506 PHE A 6 606 CZQ A S 34 FT #HET 267 509 GLN A 6 606 CZQ A S 12 FT #HET 279 521 SER A 6 606 CZQ A S 1 FT #HET 280 522 PRO A 6 606 CZQ A A 16 FT #HET 281 523 MET A 6 606 CZQ A S 13 FT #HET 282 524 CYS A 6 606 CZQ A S 4 FT #HET 292 534 SER A 6 606 CZQ A A 13 FT #HET 293 535 GLN A 6 606 CZQ A A 17 FT #HET 296 538 PHE A 6 606 CZQ A A 31 FT #HET 325 567 ASP A 5 605 MG A S 3 FT DISORDER 1 13 FT DISORDER 336 343 CC SEQUENCE 322 AA (ATOM); CC DVLAKELEDV NKWGLHVFRI AELSGNRPLT VIMHTIFQER DLLKTFKIPV DTLITYLMTL CC EDHYHADVAY HNNIHAADVV QSTHVLLSTP ALEAVFTDLE ILAAIFASAI HDVDHPGVSN CC QFLINTNSEL ALMYNDSSVL ENHHLAVGFK LLQEENCDIF QNLTKKQRQS LRKMVIDIVL CC ATDMSKHMNL LADLKTMVET KKVTSSGVLL LDNYSDRIQV LQNMVHCADL SNPTKPLQLY CC RQWTDRIMEE FFRQGDRERE RGMEISPMCD KHNASVEKSQ VGFIDYIVHP LWETWADLVH CC PDAQDILDTL EDNREWYQST IP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIF CC ATOM -------------DVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIF CC ************************************* CC SEQRES QERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL CC ATOM QERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL CC ************************************************** CC SEQRES STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS CC ATOM STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS CC ************************************************** CC SEQRES SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKH CC ATOM SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKH CC ************************************************** CC SEQRES MNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL CC ATOM MNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL CC ************************************************** CC SEQRES QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI CC ATOM QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI CC ************************************************** CC SEQRES VHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQAHHHHHH CC ATOM VHPLWETWADLVHPDAQDILDTLEDNREWYQSTIP-------- CC *********************************** SQ SEQUENCE 343 AA; MW; CN; MSIPRFGVKT EQEDVLAKEL EDVNKWGLHV FRIAELSGNR PLTVIMHTIF QERDLLKTFK IPVDTLITYL MTLEDHYHAD VAYHNNIHAA DVVQSTHVLL STPALEAVFT DLEILAAIFA SAIHDVDHPG VSNQFLINTN SELALMYNDS SVLENHHLAV GFKLLQEENC DIFQNLTKKQ RQSLRKMVID IVLATDMSKH MNLLADLKTM VETKKVTSSG VLLLDNYSDR IQVLQNMVHC ADLSNPTKPL QLYRQWTDRI MEEFFRQGDR ERERGMEISP MCDKHNASVE KSQVGFIDYI VHPLWETWAD LVHPDAQDIL DTLEDNREWY QSTIPQAHHH HHH // ID 6F8UB STANDARD; PRT; 343 AA. DT CONVERTED FROM PDB (SEQRES) 6F8U DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.100 CC R-Factor 0.168 FT #SUB 144 386 ALA B 185 427 ARG A Protein B 2 FT #SUB 145 387 LEU B 159 401 ALA A Protein B 2 FT #SUB 145 387 LEU B 162 404 PHE A Protein S 1 FT #SUB 145 387 LEU B 163 405 LYS A Protein S 2 FT #SUB 145 387 LEU B 185 427 ARG A Protein B 1 FT #SUB 146 388 MET B 146 388 MET A Protein S 3 FT #SUB 146 388 MET B 147 389 TYR A Protein A 6 FT #SUB 146 388 MET B 159 401 ALA A Protein B 1 FT #SUB 147 389 TYR B 146 388 MET A Protein S 9 FT #SUB 147 389 TYR B 147 389 TYR A Protein S 4 FT #SUB 148 390 ASN B 155 397 ASN A Protein S 7 FT #SUB 148 390 ASN B 158 400 LEU A Protein S 6 FT #SUB 148 390 ASN B 159 401 ALA A Protein S 1 FT #SUB 148 390 ASN B 185 427 ARG A Protein B 2 FT #SUB 148 390 ASN B 189 431 ILE A Protein A 3 FT #SUB 149 391 ASP B 185 427 ARG A Protein A 11 FT #SUB 155 397 ASN B 148 390 ASN A Protein A 7 FT #SUB 158 400 LEU B 148 390 ASN A Protein A 8 FT #SUB 159 401 ALA B 145 387 LEU A Protein A 2 FT #SUB 159 401 ALA B 148 390 ASN A Protein B 1 FT #SUB 162 404 PHE B 145 387 LEU A Protein S 1 FT #SUB 163 405 LYS B 142 384 GLU A Protein S 4 FT #SUB 163 405 LYS B 145 387 LEU A Protein A 2 FT #SUB 166 408 GLN B 142 384 GLU A Protein S 2 FT #SUB 166 408 GLN B 145 387 LEU A Protein S 1 FT #SUB 185 427 ARG B 144 386 ALA A Protein S 2 FT #SUB 185 427 ARG B 145 387 LEU A Protein S 1 FT #SUB 185 427 ARG B 148 390 ASN A Protein S 2 FT #SUB 185 427 ARG B 149 391 ASP A Protein S 11 FT #SUB 189 431 ILE B 148 390 ASN A Protein S 3 FT #HET 83 325 TYR B 9 603 CZQ B S 12 FT #HET 83 325 TYR B 10 604 CZQ B S 10 FT #HET 88 330 HIS B 7 601 ZN B S 3 FT #HET 124 366 HIS B 7 601 ZN B S 3 FT #HET 125 367 ASP B 7 601 ZN B S 3 FT #HET 125 367 ASP B 8 602 MG B S 3 FT #HET 132 374 SER B 10 604 CZQ B A 13 FT #HET 197 439 MET B 9 603 CZQ B S 14 FT #HET 197 439 MET B 10 604 CZQ B S 2 FT #HET 242 484 ASP B 7 601 ZN B S 3 FT #HET 243 485 LEU B 9 603 CZQ B S 1 FT #HET 245 487 ASN B 9 603 CZQ B S 9 FT #HET 245 487 ASN B 10 604 CZQ B S 9 FT #HET 246 488 PRO B 9 603 CZQ B S 2 FT #HET 246 488 PRO B 10 604 CZQ B S 2 FT #HET 253 495 TYR B 9 603 CZQ B S 5 FT #HET 253 495 TYR B 10 604 CZQ B S 5 FT #HET 256 498 TRP B 9 603 CZQ B A 3 FT #HET 256 498 TRP B 10 604 CZQ B A 3 FT #HET 257 499 THR B 9 603 CZQ B A 10 FT #HET 257 499 THR B 10 604 CZQ B A 10 FT #HET 260 502 ILE B 9 603 CZQ B S 12 FT #HET 260 502 ILE B 10 604 CZQ B S 10 FT #HET 261 503 MET B 9 603 CZQ B S 6 FT #HET 261 503 MET B 10 604 CZQ B S 6 FT #HET 264 506 PHE B 9 603 CZQ B S 14 FT #HET 264 506 PHE B 10 604 CZQ B S 20 FT #HET 280 522 PRO B 10 604 CZQ B A 9 FT #HET 281 523 MET B 9 603 CZQ B S 20 FT #HET 281 523 MET B 10 604 CZQ B S 14 FT #HET 292 534 SER B 9 603 CZQ B A 7 FT #HET 292 534 SER B 10 604 CZQ B A 10 FT #HET 293 535 GLN B 9 603 CZQ B S 17 FT #HET 293 535 GLN B 10 604 CZQ B S 17 FT #HET 296 538 PHE B 9 603 CZQ B S 23 FT #HET 296 538 PHE B 10 604 CZQ B S 26 FT #HET 300 542 ILE B 9 603 CZQ B S 9 FT DISORDER 1 13 FT DISORDER 339 343 CC SEQUENCE 325 AA (ATOM); CC DVLAKELEDV NKWGLHVFRI AELSGNRPLT VIMHTIFQER DLLKTFKIPV DTLITYLMTL CC EDHYHADVAY HNNIHAADVV QSTHVLLSTP ALEAVFTDLE ILAAIFASAI HDVDHPGVSN CC QFLINTNSEL ALMYNDSSVL ENHHLAVGFK LLQEENCDIF QNLTKKQRQS LRKMVIDIVL CC ATDMSKHMNL LADLKTMVET KKVTSSGVLL LDNYSDRIQV LQNMVHCADL SNPTKPLQLY CC RQWTDRIMEE FFRQGDRERE RGMEISPMCD KHNASVEKSQ VGFIDYIVHP LWETWADLVH CC PDAQDILDTL EDNREWYQST IPQAH CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIF CC ATOM -------------DVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIF CC ************************************* CC SEQRES QERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL CC ATOM QERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL CC ************************************************** CC SEQRES STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS CC ATOM STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS CC ************************************************** CC SEQRES SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKH CC ATOM SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKH CC ************************************************** CC SEQRES MNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL CC ATOM MNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL CC ************************************************** CC SEQRES QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI CC ATOM QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI CC ************************************************** CC SEQRES VHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQAHHHHHH CC ATOM VHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQAH----- CC ************************************** SQ SEQUENCE 343 AA; MW; CN; MSIPRFGVKT EQEDVLAKEL EDVNKWGLHV FRIAELSGNR PLTVIMHTIF QERDLLKTFK IPVDTLITYL MTLEDHYHAD VAYHNNIHAA DVVQSTHVLL STPALEAVFT DLEILAAIFA SAIHDVDHPG VSNQFLINTN SELALMYNDS SVLENHHLAV GFKLLQEENC DIFQNLTKKQ RQSLRKMVID IVLATDMSKH MNLLADLKTM VETKKVTSSG VLLLDNYSDR IQVLQNMVHC ADLSNPTKPL QLYRQWTDRI MEEFFRQGDR ERERGMEISP MCDKHNASVE KSQVGFIDYI VHPLWETWAD LVHPDAQDIL DTLEDNREWY QSTIPQAHHH HHH //