Brand  (β version)

PDB ID: 6EZ6

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Ligands
Code Name Style Show Link
C5Z Methyl 2-methoxy-5-[4-[5-[(4-propan-2-ylpiperazin-1-yl)methyl]-1,3-oxazol-2-yl]-2~{H}-indazol-6-yl]pyridine-3-carboxylate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6EZ6   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : PI3 kinase delta in complex with Methyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate
Release Data : 2017-12-27
Compound :
mol_id molecule chains synonym
1 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform A PtdIns-3-kinase subunit delta,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta,p110delta
ec: 2.7.1.153
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Spodoptera frugiperda  (taxid:7108)
gene: Pik3cd
Authors : Convery, M.A., Campos, S., Dalton, S.E.
Keywords : Covalent inhibitor, kinase, drug discovery, complex, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.04 Å )
Citation :

Selectively Targeting the Kinome-Conserved Lysine of PI3K delta as a General Approach to Covalent Kinase Inhibition.

Dalton, S.E.,Dittus, L.,Thomas, D.A.  et al.
(2018)  J. Am. Chem. Soc.  140 : 932 - 939

PubMed: 29232121
DOI: 10.1021/jacs.7b08979

Reaction

Chain : A
UniProt : O35904 (PK3CD_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+) 2.7.1.153 UniProtKB:O00329
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a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) 2.7.1.137 UniProtKB:O00329
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1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero- 3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo- inositol 3,4,5-triphosphate) + ADP + H(+) - UniProtKB:O00329
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