ID	6EZ6A	STANDARD;	PRT;	1051	AA.
DT	CONVERTED FROM PDB (SEQRES) 6EZ6
DE	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isof
DE	orm
OS	Mus musculus
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.040
CC	R-Factor	0.185
FT	#HET	757	 750 	THR	A	1	1101 	C5Z	A	S	1
FT	#HET	761	 754 	SER	A	1	1101 	C5Z	A	S	3
FT	#HET	767	 760 	TRP	A	1	1101 	C5Z	A	S	10
FT	#HET	784	 777 	ILE	A	1	1101 	C5Z	A	S	4
FT	#HET	786	 779 	LYS	A	1	1101 	C5Z	A	S	7
FT	#HET	791	 784 	LEU	A	1	1101 	C5Z	A	S	1
FT	#HET	794	 787 	ASP	A	1	1101 	C5Z	A	S	3
FT	#HET	820	 813 	TYR	A	1	1101 	C5Z	A	S	1
FT	#HET	832	 825 	ILE	A	1	1101 	C5Z	A	S	4
FT	#HET	833	 826 	GLU	A	1	1101 	C5Z	A	B	4
FT	#HET	834	 827 	VAL	A	1	1101 	C5Z	A	B	3
FT	#HET	835	 828 	VAL	A	1	1101 	C5Z	A	A	5
FT	#HET	838	 831 	SER	A	1	1101 	C5Z	A	B	1
FT	#HET	839	 832 	ASP	A	1	1101 	C5Z	A	S	2
FT	#HET	840	 833 	THR	A	1	1101 	C5Z	A	S	1
FT	#HET	907	 900 	MET	A	1	1101 	C5Z	A	S	9
FT	#HET	917	 910 	ILE	A	1	1101 	C5Z	A	S	2
FT	#HET	918	 911 	ASP	A	1	1101 	C5Z	A	A	9
FT	DISORDER	1	113
FT	DISORDER	185	193
FT	DISORDER	301	321
FT	DISORDER	406	421
FT	DISORDER	453	458
FT	DISORDER	525	527
FT	DISORDER	926	933
FT	DISORDER	1040	1051
CC	SEQUENCE	863 AA (ATOM);
CC	DRVKKLINSQ ISLLIGKGLH EFDSLRDPEV NDFRTKMRQF CEEAAAHRQQ LGWVEWLQYS
CC	FPLQLEPSAR GNRALLVNVK FEGSEESFTF QVSTKDMPLA LMACALRKKA TVFRQPLVEQ
CC	PEEYALQVNG RHEYLYGNYP LCHFQYICSC LHSGLTPHLT MVHSSSILAM RDEQSNPASL
CC	WSLEQPFSIE LIEGRKVNAD ERMKLVVQAG LFHGNEMLCK TVSSSEVNVC SEPVWKQRLE
CC	FDISVCDLPR MARLCFALYA VVDCPIAWAN LMLFDYKDQL KTGERCLYMW PSVLLNPAGT
CC	VRGNPNTESA AALVIYLPEV APHPVYFPAL EKILELGRHG ERGRITEEEQ LQLREILERG
CC	ELYEHEKDLV WKMRHEVQEH FPEALARLLL VTKWNKHEDV AQMLYLLCSW PELPVLSALE
CC	LLDFSFPDCY VGSFAIKSLR KLTDDELFQY LLQLVQVLKY ESYLDCELTK FLLGRALANR
CC	KIGHFLFWHL RSEMHVPSVA LRFGLIMEAY CRGSTHHMKV LMKQGEALSK LKALNDFVKV
CC	SSQKTTKPQT KEMMHMCMRQ ETYMEALSHL QSPLDPSTLL EEVCVEQCTF MDSKMKPLWI
CC	MYSSEEAGSA GNVGIIFKNG DDLRQDMLTL QMIQLMDVLW KQEGLDLRMT PYGCLPTGDR
CC	TGLIEVVLHS DTIANIQLNK SNMAATAAFN KDALLNWLKS KNPGEALDRA IEEFTLSCAG
CC	YCVATYVLGI GDRHSDNIMI RESGQLFHID FGHFLGNRER VPFILTYDFV HVIQQGKTNN
CC	SEKFERFRGY CERAYTILRR HGLLFLHLFA LMRAAGLPEL SCSKDIQYLK DSLALGKTEE
CC	EALKHFRVKF NEALRESWKT KVN
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MPPGVDCPMEFWTKEESQSVVVDFLLPTGVYLNFPVSRNANLSTIKQVLW
CC	ATOM   --------------------------------------------------
CC	                                                         
CC	SEQRES HRAQYEPLFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLR
CC	ATOM   --------------------------------------------------
CC	                                                         
CC	SEQRES LVAREENLYFQGGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKM
CC	ATOM   -------------DRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKM
CC	                    *************************************
CC	SEQRES RQFCEEAAAHRQQLGWVEWLQYSFPLQLEPSARGWRAGLLRVSNRALLVN
CC	ATOM   RQFCEEAAAHRQQLGWVEWLQYSFPLQLEPSARG---------NRALLVN
CC	       **********************************         *******
CC	SEQRES VKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVEQPEEYALQV
CC	ATOM   VKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVEQPEEYALQV
CC	       **************************************************
CC	SEQRES NGRHEYLYGNYPLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPA
CC	ATOM   NGRHEYLYGNYPLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPA
CC	       **************************************************
CC	SEQRES PQVQKPRAKPPPIPAKKPSSVSLWSLEQPFSIELIEGRKVNADERMKLVV
CC	ATOM   ---------------------SLWSLEQPFSIELIEGRKVNADERMKLVV
CC	                            *****************************
CC	SEQRES QAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMARLCFA
CC	ATOM   QAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMARLCFA
CC	       **************************************************
CC	SEQRES LYAVVEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWP
CC	ATOM   LYAVV----------------DCPIAWANLMLFDYKDQLKTGERCLYMWP
CC	       *****                *****************************
CC	SEQRES SVPDEKGELLNPAGTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILE
CC	ATOM   SV------LLNPAGTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILE
CC	       **      ******************************************
CC	SEQRES LGRHGERGRITEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQEHFP
CC	ATOM   LGRHGERGRITEEEQLQLREILER---GELYEHEKDLVWKMRHEVQEHFP
CC	       ************************   ***********************
CC	SEQRES EALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCYVG
CC	ATOM   EALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCYVG
CC	       **************************************************
CC	SEQRES SFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKI
CC	ATOM   SFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKI
CC	       **************************************************
CC	SEQRES GHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLK
CC	ATOM   GHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLK
CC	       **************************************************
CC	SEQRES ALNDFVKVSSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEE
CC	ATOM   ALNDFVKVSSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEE
CC	       **************************************************
CC	SEQRES VCVEQCTFMDSKMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDMLTLQM
CC	ATOM   VCVEQCTFMDSKMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDMLTLQM
CC	       **************************************************
CC	SEQRES IQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSN
CC	ATOM   IQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSN
CC	       **************************************************
CC	SEQRES MAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGD
CC	ATOM   MAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGD
CC	       **************************************************
CC	SEQRES RHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQ
CC	ATOM   RHSDNIMIRESGQLFHIDFGHFLGN--------RERVPFILTYDFVHVIQ
CC	       *************************        *****************
CC	SEQRES QGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSK
CC	ATOM   QGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSK
CC	       **************************************************
CC	SEQRES DIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNR
CC	ATOM   DIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVN-----------
CC	       ***************************************           
CC	SEQRES Q
CC	ATOM   -
CC	        
SQ	SEQUENCE	1051 AA;      MW;         CN;
	MPPGVDCPME FWTKEESQSV VVDFLLPTGV YLNFPVSRNA NLSTIKQVLW HRAQYEPLFH
	MLSDPEAYVF TCVNQTAEQQ ELEDEQRRLC DIQPFLPVLR LVAREENLYF QGGDRVKKLI
	NSQISLLIGK GLHEFDSLRD PEVNDFRTKM RQFCEEAAAH RQQLGWVEWL QYSFPLQLEP
	SARGWRAGLL RVSNRALLVN VKFEGSEESF TFQVSTKDMP LALMACALRK KATVFRQPLV
	EQPEEYALQV NGRHEYLYGN YPLCHFQYIC SCLHSGLTPH LTMVHSSSIL AMRDEQSNPA
	PQVQKPRAKP PPIPAKKPSS VSLWSLEQPF SIELIEGRKV NADERMKLVV QAGLFHGNEM
	LCKTVSSSEV NVCSEPVWKQ RLEFDISVCD LPRMARLCFA LYAVVEKAKK ARSTKKKSKK
	ADCPIAWANL MLFDYKDQLK TGERCLYMWP SVPDEKGELL NPAGTVRGNP NTESAAALVI
	YLPEVAPHPV YFPALEKILE LGRHGERGRI TEEEQLQLRE ILERRGSGEL YEHEKDLVWK
	MRHEVQEHFP EALARLLLVT KWNKHEDVAQ MLYLLCSWPE LPVLSALELL DFSFPDCYVG
	SFAIKSLRKL TDDELFQYLL QLVQVLKYES YLDCELTKFL LGRALANRKI GHFLFWHLRS
	EMHVPSVALR FGLIMEAYCR GSTHHMKVLM KQGEALSKLK ALNDFVKVSS QKTTKPQTKE
	MMHMCMRQET YMEALSHLQS PLDPSTLLEE VCVEQCTFMD SKMKPLWIMY SSEEAGSAGN
	VGIIFKNGDD LRQDMLTLQM IQLMDVLWKQ EGLDLRMTPY GCLPTGDRTG LIEVVLHSDT
	IANIQLNKSN MAATAAFNKD ALLNWLKSKN PGEALDRAIE EFTLSCAGYC VATYVLGIGD
	RHSDNIMIRE SGQLFHIDFG HFLGNFKTKF GINRERVPFI LTYDFVHVIQ QGKTNNSEKF
	ERFRGYCERA YTILRRHGLL FLHLFALMRA AGLPELSCSK DIQYLKDSLA LGKTEEEALK
	HFRVKFNEAL RESWKTKVNW LAHNVSKDNR Q
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