Brand  (β version)

PDB ID: 5X49

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Ligands
Code Name Style Show Link
01B (2s,3r)-3-amino-2-hydroxy-4-phenylbutanoic acid PoSSuM
12P Dodecaethylene glycol PoSSuM
DMS Dimethyl sulfoxide PoSSuM
EDO 1,2-ethanediol PoSSuM
MN Manganese (II) ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5X49   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of Human mitochondrial X-prolyl Aminopeptidase (XPNPEP3)
Release Data : 2017-05-17
Compound :
mol_id molecule chains synonym
1 Probable Xaa-Pro aminopeptidase 3 A,B X-Pro aminopeptidase 3,Aminopeptidase P3,APP3
ec: 3.4.11.9
fragment: UNP RESIDUES 54-507
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: XPNPEP3
expression_system_strain: BL21 (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pST50Str
Authors : Singh, R., Kumar, A., Ghosh, B., Jamdar, S., Makde, R.D.
Keywords : XPNPEP3, X-prolyl aminopeptidase, M24B, Icp55, Human, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.650 Å )
Citation :

Structure of the human aminopeptidase XPNPEP3 and comparison of its in vitro activity with Icp55 orthologs: Insights into diverse cellular processes.

Singh, R.,Jamdar, S.N.,Goyal, V.D.  et al.
(2017)  J. Biol. Chem.  292 : 10035 - 10047

PubMed: 28476889
DOI: 10.1074/jbc.M117.783357

Reaction

Chain : A, B
UniProt : Q9NQH7 (XPP3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. 3.4.11.9 PubMed:25609706, PubMed:28476889
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