Het-PDB Navi2 (PDB: 5NAI)

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Ligands
Code	Name	Link
93W	(2~{R})-2-[(1-chloranyl-4-oxidanyl-isoquinolin-3-yl)carbonylamino]-3-(1~{H}-indol-3-yl)propanoic acid	PoSSuM
F	Fluoride ion	PoSSuM
GOL	Glycerol	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
Code	Name	Show
CSD	3-sulfinoalanine

Glycosylation
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Modification
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Download interaction data: 5NAI

Code :

5NAI PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

mono-Zinc VIM-5 metallo-beta-lactamase in complex with (1-chloro-4-hydroxyisoquinoline-3-carbonyl)-D-tryptophan (Compound 1)

Release Data :

2017-05-17

Compound :

mol_id	molecule	chains	synonym
1	Class B metallo-beta-lactamase	A	Meta-beta-carbapenem,Metallo-beta-lactamase

Source :

mol_id	organism_scientific	expression_system
1	Klebsiella pneumoniae (taxid:573)	Escherichia coli BL21(DE3) (taxid:469008)
	gene: blaVIM-5 expression_system_vector_type: plasmid expression_system_plasmid: open vector based

Authors :

Li, G.-B., Brem, J., McDonough, M.A., Schofield, C.J.

Keywords :

metallo-beta-lactamase, inhibitor, complex, antibiotic resistance, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.15 Å )

Citation :

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-beta-lactamase inhibition.

Li, G.B.,Brem, J.,Lesniak, R. et al.
(2017) Chem. Commun. (Camb.) 53 : 5806 - 5809

PDB ID: 5NAI