Brand  (β version)

PDB ID: 5YV8

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Ligands
Code Name Style Show Link
91L 1-amino-4-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid PoSSuM
CL Chloride ion PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
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CAS S-(dimethylarsenic)cysteine
Glycosylation
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Structure summary

Code : 5YV8   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of CaMKK2 in complex with CKI-002
Release Data : 2018-12-05
Compound :
mol_id molecule chains synonym
1 Calcium/calmodulin-dependent protein kinase kinase 2 A CaMKK 2,Calcium/calmodulin-dependent protein kinase kinase beta,CaMKK beta
ec: 2.7.11.17
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human CELL-FREE SYNTHESIS  (taxid:32644)
gene: CAMKK2, CAMKKB, KIAA0787
expression_system_vector_type: PLASMID
expression_system_plasmid: PX070406-05
Authors : Niwa, H., Handa, N., Yokoyama, S.
Keywords : ATP-BINDING, KINASE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, PROTEIN-INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.927 Å )
Citation :

Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method.

Takaya, D.,Niwa, H.,Mikuni, J.  et al.
(2020)  J.Mol.Graph.Model.  99 : 107599 - 107599

PubMed: 32348940
DOI: 10.1016/j.jmgm.2020.107599

Reaction

Chain : A
UniProt : Q96RR4 (KKCC2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.17 -
-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.17 -
-