Het-PDB Navi2 (PDB: 5WQA)

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Ligands
Code	Name	Link
J20	1-[2-(4-hydroxyphenyl)ethynyl]-9,9-bis(4-methoxyphenyl)-7-oxidanyl-fluorene-2-carbaldehyde	PoSSuM
ZN	Zinc ion	PoSSuM
MG	Magnesium ion	PoSSuM

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Download interaction data: 5WQA

Code :

5WQA PDBj RCSB PDB PDBe

Header :

HYDROLASE/INHIBITOR

Title :

Crystal structure of PDE4D catalytic domain complexed with Selaginpulvilins K

Release Data :

2017-02-22

Compound :

mol_id	molecule	chains	synonym
1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	A,B	DPDE3,PDE43
	ec: 3.1.4.53 fragment: UNP residues 381-714

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21 (taxid:511693)
	gene: PDE4D, DPDE3 expression_system_strain: BL21 expression_system_vector_type: PLASMID

Authors :

Huang, Y., Zhang, T., Zheng, X., Yin, S., Luo, H.B.

Keywords :

Natural PDE4 inhibtor, HYDROLASE-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.30 Å )

Citation :

The discovery, complex crystal structure, and recognition mechanism of a novel natural PDE4 inhibitor from Selaginella pulvinata

Huang, Y.,Liu, X.,Wu, D. et al.
(2017) Biochem. Pharmacol. 130 : 51 - 59

Chain :

A, B

UniProt :

Q08499 (PDE4D_HUMAN)

PDB ID: 5WQA