ID	5WQAA	STANDARD;	PRT;	334	AA.
DT	CONVERTED FROM PDB (SEQRES) 5WQA
DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.300
CC	R-Factor	0.219
FT	#SUB	140	 218 	GLU	A	161	 239 	LYS	B	Protein	S	1
FT	#SUB	142	 220 	ALA	A	183	 261 	ARG	B	Protein	B	2
FT	#SUB	143	 221 	LEU	A	157	 235 	ALA	B	Protein	B	2
FT	#SUB	143	 221 	LEU	A	160	 238 	PHE	B	Protein	S	1
FT	#SUB	143	 221 	LEU	A	161	 239 	LYS	B	Protein	S	1
FT	#SUB	144	 222 	MET	A	144	 222 	MET	B	Protein	S	3
FT	#SUB	144	 222 	MET	A	145	 223 	TYR	B	Protein	A	6
FT	#SUB	144	 222 	MET	A	157	 235 	ALA	B	Protein	B	1
FT	#SUB	145	 223 	TYR	A	144	 222 	MET	B	Protein	S	6
FT	#SUB	145	 223 	TYR	A	145	 223 	TYR	B	Protein	S	4
FT	#SUB	146	 224 	ASN	A	153	 231 	ASN	B	Protein	S	6
FT	#SUB	146	 224 	ASN	A	156	 234 	LEU	B	Protein	S	7
FT	#SUB	146	 224 	ASN	A	157	 235 	ALA	B	Protein	S	1
FT	#SUB	146	 224 	ASN	A	183	 261 	ARG	B	Protein	B	2
FT	#SUB	146	 224 	ASN	A	187	 265 	ILE	B	Protein	B	2
FT	#SUB	147	 225 	ASP	A	183	 261 	ARG	B	Protein	A	11
FT	#SUB	153	 231 	ASN	A	146	 224 	ASN	B	Protein	A	7
FT	#SUB	156	 234 	LEU	A	146	 224 	ASN	B	Protein	S	5
FT	#SUB	157	 235 	ALA	A	143	 221 	LEU	B	Protein	A	2
FT	#SUB	157	 235 	ALA	A	144	 222 	MET	B	Protein	S	1
FT	#SUB	157	 235 	ALA	A	146	 224 	ASN	B	Protein	B	1
FT	#SUB	160	 238 	PHE	A	143	 221 	LEU	B	Protein	S	1
FT	#SUB	161	 239 	LYS	A	140	 218 	GLU	B	Protein	S	3
FT	#SUB	161	 239 	LYS	A	143	 221 	LEU	B	Protein	A	2
FT	#SUB	183	 261 	ARG	A	142	 220 	ALA	B	Protein	S	2
FT	#SUB	183	 261 	ARG	A	146	 224 	ASN	B	Protein	S	1
FT	#SUB	183	 261 	ARG	A	147	 225 	ASP	B	Protein	S	9
FT	#SUB	187	 265 	ILE	A	146	 224 	ASN	B	Protein	S	1
FT	#HET	82	 160 	HIS	A	1	501 	J20	A	S	5
FT	#HET	86	 164 	HIS	A	2	502 	ZN	A	S	3
FT	#HET	122	 200 	HIS	A	2	502 	ZN	A	S	3
FT	#HET	123	 201 	ASP	A	2	502 	ZN	A	S	3
FT	#HET	123	 201 	ASP	A	3	503 	MG	A	S	3
FT	#HET	130	 208 	SER	A	1	501 	J20	A	S	3
FT	#HET	152	 230 	GLU	A	3	503 	MG	A	S	1
FT	#HET	195	 273 	MET	A	1	501 	J20	A	A	6
FT	#HET	198	 276 	HIS	A	1	501 	J20	A	S	4
FT	#HET	240	 318 	ASP	A	2	502 	ZN	A	S	3
FT	#HET	258	 336 	ILE	A	1	501 	J20	A	S	1
FT	#HET	262	 340 	PHE	A	1	501 	J20	A	S	8
FT	#HET	265	 343 	GLN	A	1	501 	J20	A	S	3
FT	#HET	278	 356 	PRO	A	1	501 	J20	A	A	5
FT	#HET	279	 357 	MET	A	1	501 	J20	A	S	8
FT	#HET	280	 358 	CYS	A	1	501 	J20	A	S	1
FT	#HET	291	 369 	GLN	A	1	501 	J20	A	S	4
FT	#HET	294	 372 	PHE	A	1	501 	J20	A	S	21
FT	#HET	298	 376 	ILE	A	1	501 	J20	A	S	4
CC	SEQUENCE	334 AA (ATOM);
CC	IPRFGVKTEQ EDVLAKELED VNKWGLHVFR IAELSGNRPL TVIMHTIFQE RDLLKTFKIP
CC	VDTLITYLMT LEDHYHADVA YHNNIHAADV VQSTHVLLST PALEAVFTDL EILAAIFASA
CC	IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF KLLQEENCDI FQNLTKKQRQ
CC	SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL LLDNYSDRIQ VLQNMVHCAD
CC	LSNPTKPLQL YRQWTDRIME EFFRQGDRER ERGMEISPMC DKHNASVEKS QVGFIDYIVH
CC	PLWETWADLV HPDAQDILDT LEDNREWYQS TIPQ
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES IPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE
CC	ATOM   IPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE
CC	       **************************************************
CC	SEQRES RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
CC	ATOM   RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
CC	       **************************************************
CC	SEQRES PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV
CC	ATOM   PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV
CC	       **************************************************
CC	SEQRES LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN
CC	ATOM   LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN
CC	       **************************************************
CC	SEQRES LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL
CC	ATOM   LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL
CC	       **************************************************
CC	SEQRES YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH
CC	ATOM   YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH
CC	       **************************************************
CC	SEQRES PLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ
CC	ATOM   PLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ
CC	       **********************************
SQ	SEQUENCE	334 AA;      MW;         CN;
	IPRFGVKTEQ EDVLAKELED VNKWGLHVFR IAELSGNRPL TVIMHTIFQE RDLLKTFKIP
	VDTLITYLMT LEDHYHADVA YHNNIHAADV VQSTHVLLST PALEAVFTDL EILAAIFASA
	IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF KLLQEENCDI FQNLTKKQRQ
	SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL LLDNYSDRIQ VLQNMVHCAD
	LSNPTKPLQL YRQWTDRIME EFFRQGDRER ERGMEISPMC DKHNASVEKS QVGFIDYIVH
	PLWETWADLV HPDAQDILDT LEDNREWYQS TIPQ
//
ID	5WQAB	STANDARD;	PRT;	334	AA.
DT	CONVERTED FROM PDB (SEQRES) 5WQA
DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.300
CC	R-Factor	0.219
FT	#SUB	140	 218 	GLU	B	161	 239 	LYS	A	Protein	S	3
FT	#SUB	142	 220 	ALA	B	183	 261 	ARG	A	Protein	B	2
FT	#SUB	143	 221 	LEU	B	157	 235 	ALA	A	Protein	B	2
FT	#SUB	143	 221 	LEU	B	160	 238 	PHE	A	Protein	S	1
FT	#SUB	143	 221 	LEU	B	161	 239 	LYS	A	Protein	S	2
FT	#SUB	144	 222 	MET	B	144	 222 	MET	A	Protein	S	3
FT	#SUB	144	 222 	MET	B	145	 223 	TYR	A	Protein	A	6
FT	#SUB	144	 222 	MET	B	157	 235 	ALA	A	Protein	B	1
FT	#SUB	145	 223 	TYR	B	144	 222 	MET	A	Protein	S	6
FT	#SUB	145	 223 	TYR	B	145	 223 	TYR	A	Protein	S	4
FT	#SUB	146	 224 	ASN	B	153	 231 	ASN	A	Protein	S	7
FT	#SUB	146	 224 	ASN	B	156	 234 	LEU	A	Protein	S	5
FT	#SUB	146	 224 	ASN	B	157	 235 	ALA	A	Protein	S	1
FT	#SUB	146	 224 	ASN	B	183	 261 	ARG	A	Protein	B	1
FT	#SUB	146	 224 	ASN	B	187	 265 	ILE	A	Protein	B	1
FT	#SUB	147	 225 	ASP	B	183	 261 	ARG	A	Protein	S	9
FT	#SUB	153	 231 	ASN	B	146	 224 	ASN	A	Protein	A	6
FT	#SUB	156	 234 	LEU	B	146	 224 	ASN	A	Protein	S	7
FT	#SUB	157	 235 	ALA	B	143	 221 	LEU	A	Protein	A	2
FT	#SUB	157	 235 	ALA	B	144	 222 	MET	A	Protein	S	1
FT	#SUB	157	 235 	ALA	B	146	 224 	ASN	A	Protein	B	1
FT	#SUB	160	 238 	PHE	B	143	 221 	LEU	A	Protein	S	1
FT	#SUB	161	 239 	LYS	B	140	 218 	GLU	A	Protein	S	1
FT	#SUB	161	 239 	LYS	B	143	 221 	LEU	A	Protein	S	1
FT	#SUB	183	 261 	ARG	B	142	 220 	ALA	A	Protein	S	2
FT	#SUB	183	 261 	ARG	B	146	 224 	ASN	A	Protein	S	2
FT	#SUB	183	 261 	ARG	B	147	 225 	ASP	A	Protein	S	11
FT	#SUB	187	 265 	ILE	B	146	 224 	ASN	A	Protein	S	2
FT	#HET	82	 160 	HIS	B	4	501 	J20	B	S	5
FT	#HET	86	 164 	HIS	B	6	503 	ZN	B	S	3
FT	#HET	122	 200 	HIS	B	6	503 	ZN	B	S	3
FT	#HET	123	 201 	ASP	B	5	502 	MG	B	S	3
FT	#HET	123	 201 	ASP	B	6	503 	ZN	B	S	3
FT	#HET	130	 208 	SER	B	4	501 	J20	B	S	3
FT	#HET	195	 273 	MET	B	4	501 	J20	B	S	3
FT	#HET	198	 276 	HIS	B	4	501 	J20	B	S	3
FT	#HET	240	 318 	ASP	B	6	503 	ZN	B	S	3
FT	#HET	258	 336 	ILE	B	4	501 	J20	B	S	1
FT	#HET	262	 340 	PHE	B	4	501 	J20	B	S	10
FT	#HET	265	 343 	GLN	B	4	501 	J20	B	S	3
FT	#HET	278	 356 	PRO	B	4	501 	J20	B	S	6
FT	#HET	279	 357 	MET	B	4	501 	J20	B	S	6
FT	#HET	280	 358 	CYS	B	4	501 	J20	B	S	1
FT	#HET	291	 369 	GLN	B	4	501 	J20	B	S	4
FT	#HET	294	 372 	PHE	B	4	501 	J20	B	S	20
FT	#HET	298	 376 	ILE	B	4	501 	J20	B	S	5
CC	SEQUENCE	334 AA (ATOM);
CC	IPRFGVKTEQ EDVLAKELED VNKWGLHVFR IAELSGNRPL TVIMHTIFQE RDLLKTFKIP
CC	VDTLITYLMT LEDHYHADVA YHNNIHAADV VQSTHVLLST PALEAVFTDL EILAAIFASA
CC	IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF KLLQEENCDI FQNLTKKQRQ
CC	SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL LLDNYSDRIQ VLQNMVHCAD
CC	LSNPTKPLQL YRQWTDRIME EFFRQGDRER ERGMEISPMC DKHNASVEKS QVGFIDYIVH
CC	PLWETWADLV HPDAQDILDT LEDNREWYQS TIPQ
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES IPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE
CC	ATOM   IPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE
CC	       **************************************************
CC	SEQRES RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
CC	ATOM   RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
CC	       **************************************************
CC	SEQRES PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV
CC	ATOM   PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV
CC	       **************************************************
CC	SEQRES LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN
CC	ATOM   LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN
CC	       **************************************************
CC	SEQRES LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL
CC	ATOM   LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL
CC	       **************************************************
CC	SEQRES YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH
CC	ATOM   YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH
CC	       **************************************************
CC	SEQRES PLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ
CC	ATOM   PLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ
CC	       **********************************
SQ	SEQUENCE	334 AA;      MW;         CN;
	IPRFGVKTEQ EDVLAKELED VNKWGLHVFR IAELSGNRPL TVIMHTIFQE RDLLKTFKIP
	VDTLITYLMT LEDHYHADVA YHNNIHAADV VQSTHVLLST PALEAVFTDL EILAAIFASA
	IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF KLLQEENCDI FQNLTKKQRQ
	SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL LLDNYSDRIQ VLQNMVHCAD
	LSNPTKPLQL YRQWTDRIME EFFRQGDRER ERGMEISPMC DKHNASVEKS QVGFIDYIVH
	PLWETWADLV HPDAQDILDT LEDNREWYQS TIPQ
//